国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (4): 407-413.doi: 10.7518/gjkq.2023068

• 口腔肿瘤学专栏 • 上一篇    下一篇

近红外荧光探针在口腔癌诊断中应用的研究进展

姜玥莹(),何宇添,李婷,周蓉卉()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔颌面外科 成都 610041
  • 收稿日期:2022-11-11 修回日期:2023-02-02 出版日期:2023-07-01 发布日期:2023-06-21
  • 通讯作者: 周蓉卉
  • 作者简介:姜玥莹，博士，Email：jyyabby@126.com
  • 基金资助:
    国家自然科学基金青年基金(82102694)

Research progress on the application of near infrared fluorescence probe in the diagnosis of oral cancer

Jiang Yueying(),He Yutian,Li Ting,Zhou Ronghui.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-11-11 Revised:2023-02-02 Online:2023-07-01 Published:2023-06-21
  • Contact: Ronghui. Zhou
  • Supported by:
    the National Science Fund for Distinguished Young Scholars(82102694)

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摘要：

荧光成像因具有侵入性低、灵敏度高、可实时检测等优点，在癌症诊断及药物靶向等研究领域备受关注。自体荧光检查术可利用病变组织与正常组织对同一波长激发光产生的荧光差异对癌变组织进行诊断，或是利用药物本身的荧光对癌变组织进行示踪。然而，上述荧光诊断技术的特异性较差且检测灵敏度相对较低。与现有荧光诊断方法相比，近红外荧光诊断技术受背景信号干扰小且能对更深部组织进行成像，可有效弥补自体荧光检查术的不足，对辅助临床上口腔癌症的诊断具有重要意义。基于此，本文综述了应用于口腔癌诊断领域的第一、二近红外荧光窗口成像探针的构建方法，并进一步讨论了其在标记口腔癌症中的研究进展，为实现口腔癌实时精准诊断研究提供参考。

关键词: 口腔癌, 近红外荧光, 诊断, 纳米探针, 分子探针

Abstract:

Fluorescence imaging has attracted much attention in cancer diagnosis and drug targeting due to its advantages of low invasion, high sensitivity and real-time detection. Autofluorescence can be used to diagnose cancerous tissue by the difference of fluorescence generated by the same wavelength excitation light between pathological tissue and normal tissue, or to trace cancerous tissue by the fluorescence of the drug itself. However, the specificity and sensitivity of these fluorescence diagnostic techniques are poor. Compared with the existing fluorescence diagnosis methods, near-infrared fluorescence diagnosis technology is less interfered by background signals and can image deeper tissues, which can effectively make up for the deficiency of autofluorescence examination, and has important significance for the clinical diagnosis of oral cancer. Based on this, this paper reviews the construction methods of the first and second near-infrared fluorescent window imaging probes applied in the field of oral cancer diagnosis, and further discusses its research progress in the labeling of oral cancer, providing a reference for the real-time and accurate diagnosis of oral cancer.

Key words: oral cancer, near-infrared fluorescence, diagnosis, nanoprobe, molecular probe

中图分类号: 

  • R 782
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