国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (2): 185-191.doi: 10.7518/gjkq.2018.02.011

• 综述 • 上一篇    下一篇

褪黑素对硬组织生长发育的调控作用

陈浩玲, 林宇婧, 朱慧, 杨婷婷, 黄芳   

  1. 中山大学光华口腔医学院•附属口腔医院儿童口腔科
    广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2017-07-18 修回日期:2017-11-25 出版日期:2018-03-01 发布日期:2018-03-01
  • 通讯作者: 黄芳,主任医师,博士,Email：hfang@mail.sysu.edu.cn
  • 作者简介:陈浩玲,学士,Email：852881097@qq.com
  • 基金资助:
    国家自然科学基金（81470760,81371107）

Effects of melatonin regulating on growth and development of hard tissues

Chen Haoling, Lin Yujing, Zhu Hui, Yang Tingting, Huang Fang   

  1. Guanghua School of Stomatology, Dept. of Pediatric Dentistry, Hospital of Stomatology, Sun Yat-sen University
    Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2017-07-18 Revised:2017-11-25 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81470760, 81371107).

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摘要： 褪黑素的作用及其机制是近年来的研究热点之一。大量研究发现,褪黑素有促进成骨细胞增殖和分化、抑制破骨细胞活性、诱导骨髓间充质干细胞向成骨细胞分化的作用。褪黑素还能抑制牙乳头细胞增殖和促进分化。褪黑素与骨和牙齿的相关疾病也有密切关系,其机制可能与褪黑素受体及受体作用通路有关。本文主要就褪黑素对骨和牙齿的作用及其可能机制进行总结叙述。

关键词: 褪黑素, 骨, 牙齿, 调控, 发育

Abstract: The function and mechanism of melatonin are current research focus. A number of studies showed that melatonin can promote the proliferation and differentiation of osteoblasts, thereby inhibiting the activity of osteoclasts and inducing the differentiation of bone mesenchymal stem cells into osteoblasts. Melatonin can also inhibit the proliferation of dental papilla cells and promote their differentiation. Melatonin is closely related with teeth and bone diseases. The mechanism may be associated with melatonin receptors and their functional pathways. In this review, we summarise the effects of melatonin on hard tissue and its potential mechanism.

Key words: melatonin, bone, teeth, regulation, development

中图分类号: 

  • Q813.1
[1] Harpsøe NG, Andersen LP, Gögenur I, et al.Clinical pharmacokinetics of melatonin: a systematic review[J]. Eur J Clin Pharmacol, 2015, 71(8):901-909.
[2] Owino S, Contreras-Alcantara S, Baba K, et al.Me-latonin signaling controls the daily rhythm in blood glucose levels independent of peripheral clocks[J]. PLoS One, 2016, 11(1):e148214.
[3] Di Bella G, Mascia F, Gualano L, et al.Melatonin anticancer effects: review[J]. Int J Mol Sci, 2013, 14(2):2410-2430.
[4] Kumasaka S, Shimozuma M, Kawamoto T, et al.Po-ssible involvement of melatonin in tooth develop-ment: expression of melatonin 1a receptor in human and mouse tooth germs[J]. Histochem Cell Biol, 2010, 133(5):577-584.
[5] Evely KM, Hudson RL, Dubocovich ML, et al.Me-latonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula[J]. Synapse, 2016, 70(5):181-186.
[6] 李海波, 邱勇, 李卫国, 等. 人骨髓间充质干细胞褪黑素受体的表达及其意义[J]. 中国脊柱脊髓杂志, 2008, 18(9):707-711.
Li HB, Qiu Y, Li WG, et al.Identification of mela-tonin receptor in human bone mesenchymals stromal cells and its significance[J]. Chin J Spine Spinal Cord, 2008, 18(9):707-711.
[7] Man GC, Wong JH, Wang WW, et al.Abnormal melatonin receptor 1B expression in osteoblasts from girls with adolescent idiopathic scoliosis[J]. J Pineal Res, 2011, 50(4):395-402.
[8] Liu J, Huang F, He HW.Melatonin effects on hard tissues: bone and tooth[J]. Int J Mol Sci, 2013, 14(5): 10063-10074.
[9] Koyama H, Nakade O, Takada Y, et al.Melatonin at pharmacologic doses increases bone mass by supp-ressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activa-tion[J]. 2002, 17(7):1219-1229.
[10] López-Martinez F, Olivares Ponce PN, Guerra Ro-dríguez M, et al. Melatonin: bone metabolism in oral cavity[J]. Int J Dent, 2012, 2012:628406.
[11] Nakade O, Koyama H, Ariji H, et al.Melatonin sti-mulates proliferation and typeⅠcollagen synthesis in human bone cells in vitro[J]. J Pineal Res, 1999, 27(2):106-110.
[12] Zhang L, Su P, Xu C, et al.Melatonin inhibits adipo-genesis and enhances osteogenesis of human mesen-chymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression[J]. J Pineal Res, 2010, 49(4):364-372.
[13] Feskanich D, Hankinson SE, Schernhammer ES.Nightshift work and fracture risk: the nurses’ health study[J]. Osteoporos Int, 2009, 20(4):537-542.
[14] 傅刚, 郭源, 朱振华, 等. 鸡松果体切除脊柱侧凸症动物模型的建立[J]. 中华实验外科杂志, 2012, 29(12):2603-2604.
Fu G, Guo Y, Zhu ZH, et al.Build the scoliosis animal model by pinealectomized chickens[J]. Chin J Exp Surg, 2012, 29(12):2603-2604.
[15] 吴涛, 朱泽章, 刘军, 等. 双足直立诱导低褪黑素水平雌性小鼠脊柱侧凸模型的观察[J]. 中国脊柱脊髓杂志, 2014, (4):350-354.
Wu T, Zhu ZZ, Liu J, et al.The effect of bipedal am-putation on a scoliosis model of female mouse with low melatonin level[J]. Chin J Spine Spinal Cord, 2014, (4):350-354.
[16] Yang P, Liu H, Lin J, et al.The association of rs4753426 polymorphism in the melatonin receptor 1B (MTNR1B) gene and susceptibility to adolescent idiopathic scoliosis: a systematic review and Meta-analysis[J]. Pain Physician, 2015, 18(5):419-431.
[17] 高云飞, 李思敏, 郭良微, 等. 富血小板血浆-褪黑素复合物促进兔桡骨缺损修复的实验研究[J]. 口腔医学研究, 2014, 30(9):814-817.
Gao YF, Li SM, Guo LW, et al.Study of repairing the bone defect with platelet rich plasma/melatonin composites[J]. J Oral Sci Res, 2014, 30(9):814-817.
[18] 高云飞, 郭良微, 周晋, 等. 富血小板血浆复合物促进牙周骨缺损修复的实验研究[J]. 现代口腔医学杂志, 2014, 28(3):155-158.
Gao YF, Guo LW, Zhou J, et al.The effect of plate-let-rich plasma composites on the regeneration of rats periodontal tissue[J]. J Modern Stomatol, 2014, 28(3):155-158.
[19] Ramírez-Fernández MP, Calvo-Guirado JL, De-Val JE, et al.Melatonin promotes angiogenesis during repair of bone defects: a radiological and histomor-phometric study in rabbit tibiae[J]. Clin Oral Investig, 2013, 17(1):147-158.
[20] Halıcı M, Öner M, Güney A, et al.Melatonin pro-motes fracture healing in the rat model[J]. Eklem Hastalik Cerrahisi, 2010, 21(3):172-177.
[21] Calvo-Guirado JL, Gómez-Moreno G, Barone A, et al.Melatonin plus porcine bone on discrete calcium deposit implant surface stimulates osteointegration in dental implants[J]. J Pineal Res, 2009, 47(2):164-172.
[22] Calvo-Guirado JL, Gómez-Moreno G, López-Mari L, et al.Actions of melatonin mixed with collagenized porcine bone versus porcine bone only on osteointe-gration of dental implants[J]. J Pineal Res, 2010, 48(3):194-203.
[23] Calvo-Guirado JL, Ramírez-Fernández MP, Gómez-Moreno G, et al.Melatonin stimulates the growth of new bone around implants in the tibia of rabbits[J]. J Pineal Res, 2010, 49(4):356-363.
[24] Guardia J, Gómez-Moreno G, Ferrera MJ, et al.Evaluation of effects of topic melatonin on implant surface at 5 and 8 weeks in Beagle dogs[J]. Clin Implant Dent Relat Res, 2011, 13(4):262-268.
[25] Muñoz F, López-Peña M, Miño N, et al.Topical application of melatonin and growth hormone acce-lerates bone healing around dental implants in dogs[J]. Clin Implant Dent Relat Res, 2012, 14(2):226-235.
[26] Tresguerres IF, Clemente C, Blanco L, et al.Effects of local melatonin application on implant osseoin-tegration[J]. Clin Implant Dent Relat Res, 2012, 14(3):395-399.
[27] Dundar S, Yaman F, Saybak A, et al.Evaluation of effects of topical melatonin application on osseointe-gration of dental implant: an experimental study[J]. J Oral Implantol, 2016, 42(5):386-389.
[28] 周红玉, 刘洁, 何宏文, 等. 褪黑素对大鼠牙乳头细胞和牙齿发育的影响[J/OL]. 中华口腔医学研究杂志(电子版), 2012, 6(2):127-134.
Zhou HY, Liu J, He HW, et al.Effects of melatonin on the rat dental papilla cells and tooth development in vitro and in vivo[J/OL]. Chin J Stomatol Res (Elect Ed), 2012, 6(2):127-134.
[29] Cengiz MI, Cengiz S, Wang HL.Melatonin and oral cavity[J]. Int J Dent, 2012, 2012:491872.
[30] Reiter RJ, Rosales-Corral SA, Liu XY, et al.Melatonin in the oral cavity: physiological and pathological implications[J]. J Periodontal Res, 2015, 50(1):9-17.
[31] Liu J, Zhou H, Fan W, et al.Melatonin influences proliferation and differentiation of rat dental papilla cells in vitro and dentine formation in vivo by altering mitochondrial activity[J]. J Pineal Res, 2013, 54(2):170-178.
[32] Tachibana R, Tatehara S, Kumasaka S, et al.Effect of melatonin on human dental papilla cells[J]. Int J Mol Sci, 2014, 15(10):17304-17317.
[33] 汤玲玲, 包志凡, 陈旭, 等. β-catenin在人恒牙牙髓及牙乳头中的表达[J]. 上海口腔医学, 2012, 21(3): 270-273.
Tang LL, Bao ZF, Chen X, et al.Expression of β-catenin in the apical papilla and dental pulp tissues of human permanent teeth[J]. Shanghai J Stomatol, 2012, 21(3):270-273.
[34] Han N, Zheng Y, Li R, et al.β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2[J]. PLoS One, 2014, 9(2):e88890.
[35] Chen S, Rani S, Wu Y, et al.Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation[J]. J Biol Chem, 2005, 280(33):29717-29727.
[36] Komori T.Regulation of bone development and ex-tracellular matrix protein genes by RUNX2[J]. Cell Tissue Res, 2010, 339(1):189-195.
[37] Tamura H, Nakamura Y, Terron MP, et al.Melatonin and pregnancy in the human[J]. Reprod Toxicol, 2008, 25(3):291-303.
[38] 李长春, 孙莲莲, 姜忠敏, 等. 1,25(OH)2D3在牙乳头干细胞成骨分化中的作用[J]. 天津医药, 2014, 42(5):421-423.
Li CC, Sun LL, Jiang ZM, et al.Functional roles of 1,25(OH)2D3 in osteogenic differentiation of the den-tal papilla stem cells[J]. Tianjin Med J, 2014, 42(5): 421-423.
[39] 卢艳红, 付深利, 何依帆, 等. AFMK对大鼠牙乳头细胞增殖和分化的影响[J/OL]. 中华口腔医学研究杂志(电子版), 2013, 7(2):105-107.
Lu YH, Fu SL, He YF, et al.The effects of AFMK on proliferation and differentiation of rat dental pa-pilla cells[J/OL]. Chi J Stomatol Res (Elect Ed), 2013, 7(2):105-107.
[40] Silva SO, Rodrigues MR, Ximenes VF, et al.Neutro-phils as a specific target for melatonin and kynura-mines: effects on cytokine release[J]. J Neuroim-munol, 2004, 156(1/2):146-152.
[41] 王月君, 刘大勇, 范志朋, 等. 维生素C促进根尖牙乳头间充质干细胞组蛋白去甲基化酶KDM2B和KDM5C表达的研究[J]. 口腔医学研究, 2015, 31(5):466-469.
Wang YJ, Liu DY, Fan ZP, et al.Vitamin C enhanced the expressions of histone demethylase KDM2B and KDM5C in stem cells from apical papilla[J]. J Oral Sci Res, 2015, 31(5):466-469.
[42] 邱思慧, 汪俊. Ca(OH)2和Hoshino制剂对猪牙乳头细胞增殖的影响[J]. 上海口腔医学, 2015, 24(4): 419-422.
Qiu SH, Wang J.Effects of calcium hydroxide and Hoshino’s paste on the proliferation of porcine dental papilla cells[J]. Shanghai J Stomatol, 2015, 24(4): 419-422.
[43] 王燕萍, 曹灵, 吴锦涛, 等. 17β-雌二醇对人根尖牙乳头干细胞RANKL、OPG表达影响的研究[J]. 口腔生物医学, 2012, 3(4):185-188.
Wang YP, Cao L, Wu JT, et al.Effect of 17β-estro-dial on the expression of RANKL and OPG in human stem cells from apical papillae[J]. Oral Biomed, 2012, 3(4):185-188.
[44] Gronthos S, Mankani M, Brahim J, et al.Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo[J]. Proc Natl Acad Sci U S A, 2000, 97(25): 13625-13630.
[45] Kong X, Li X, Cai Z, et al.Melatonin regulates the viability and differentiation of rat midbrain neural stem cells[J]. Cell Mol Neurobiol, 2008, 28(4):569-579.
[46] Maioli M, Basoli V, Santaniello S, et al.Osteogenesis from dental pulp derived stem cells: a novel condi-tioned medium including melatonin within a mixture of hyaluronic, butyric, and retinoic acids[J]. Stem Cells Int, 2016, 2016:2056416.
[47] Cho YA, Noh K, Jue SS, et al.Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis[J]. J Pineal Res, 2015, 58(1):127-135.
[48] Bei M, Maas R.FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development[J]. Development, 1998, 125(21):4325-4333.
[49] Vainio S, Karavanova I, Jowett A, et al.Identifica-tion of BMP-4 as a signal mediating secondary in-duction between epithelial and mesenchymal tissues during early tooth development[J]. Cell, 1993, 75(1): 45-58.
[50] 刘丽, 林运鸿, 邓春梅, 等. 牙齿发育与BMP信号通路的关系[J]. 现代生物医学进展, 2010, 10(19): 3760-3761.
Liu L, Lin HY, Deng CM, et al.Relationship be-tween tooth development and BMP signaling pa-thway[J]. Prog Modern Biomed, 2010, 10(19):3760-3761.
[51] Xu X, Han J, Ito Y, et al.Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development[J]. Dev Cell, 2008, 15(2):322-329.
[52] Lee SY, Kim SY, Park SH, et al.Effects of recom-binant dentin sialoprotein in dental pulp cells[J]. J Dent Res, 2012, 91(4):407-412.
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[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
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