国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (6): 639-645.doi: 10.7518/gjkq.2023103

• 口颌面发育专栏 • 上一篇    下一篇

牙根发育异常疾病概述

王京楠(),邓淑丽()   

  1. 浙江大学医学院附属口腔医院牙体牙髓科 浙江大学口腔医学院 浙江省口腔疾病临床医学研究中心浙江省口腔生物医学研究重点实验室 浙江大学癌症研究院 杭州 310000
  • 收稿日期:2023-04-18 修回日期:2023-08-06 出版日期:2023-11-01 发布日期:2023-10-24
  • 通讯作者: 邓淑丽
  • 作者简介:王京楠,住院医师,硕士,Email:wangjn925@163.com
  • 基金资助:
    浙江省“尖兵”“领雁”研发攻关计划(2022C03060)

Root dysplasia of teeth: a review

Wang Jingnan(),Deng Shuli.()   

  1. Dept. of Cariology and Endodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310000, China
  • Received:2023-04-18 Revised:2023-08-06 Online:2023-11-01 Published:2023-10-24
  • Contact: Shuli. Deng
  • Supported by:
    “Pioneer” and “Leading Goose” Research and Development Program in Zhe-jiang Province(2022C03060)

摘要:

牙根发育异常严重影响牙齿正常行使功能,甚至导致牙齿的早期脱落。牙根发育异常的表现复杂多样,目前对该类疾病仍认识不足,具体的致病机制尚不清楚。本文在总结大量病例报告及研究进展的基础上,就主要的牙根发育异常疾病的临床表现和可能的致病机制进行综述。

关键词: 牙根, 牙根发育, 牙根发育异常

Abstract:

Abnormal root development seriously affects the function of teeth, and even causes early tooth loss. The development of tooth root is complex. At present, the diagnosis and treatment of these diseases are still poorly understood, and the specific pathogenesis is still unclear. Based on a large number of research and case reports, we review the clinical manifestations and possible pathogenesis of root dysplasia.

Key words: tooth root, tooth root development, root dysplasia

中图分类号: 

  • R 781

《口内数字印模技术》出版发行"

1 Luder HU. Malformations of the tooth root in humans[J]. Front Physiol, 2015, 6: 307.
2 Wang J, Feng JQ. Signaling pathways critical for tooth root formation[J]. J Dent Res, 2017, 96(11): 1221-1228.
3 Chetty M, Roomaney IA, Beighton P. Taurodontism in dental genetics[J]. BDJ Open, 2021, 7: 25.
4 Dineshshankar J, Sivakumar M, Balasubramanium AM, et al. Taurodontism[J]. J Pharm Bioallied Sci, 2014, 6(): S13-S15.
5 Giambersio E, Barile V, Giambersio AM. Klinefelter’s syndrome and taurodontism[J]. Arch Ital Urol Androl, 2019, 91(2).
6 Jayashankara C, Shivanna AK, Sridhara K, et al. Taurodontism: a dental rarity[J]. J Oral Maxillofac Pathol, 2013, 17(3): 478.
7 Hermans F, Hemeryck L, Lambrichts I, et al. Intertwined signaling pathways governing tooth development: a give-and-take between canonical Wnt and shh[J]. Front Cell Dev Biol, 2021, 9: 758203.
8 Yu M, Liu Y, Liu HC, et al. Distinct impacts of bi-allelic WNT10A mutations on the permanent and primary dentitions in odonto-onycho-dermal dysplasia[J]. Am J Med Genet A, 2019, 179(1): 57-64.
9 Yu M, Liu Y, Wang Y, et al. Epithelial Wnt10a is essential for tooth root furcation morphogenesis[J]. J Dent Res, 2020, 99(3): 311-319.
10 Yang J, Wang SK, Choi M, et al. Taurodontism, va-riations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds[J]. Mol Genet Genomic Med, 2015, 3(1): 40-58.
11 Fons Romero JM, Star H, Lav R, et al. The impact of the eda pathway on tooth root development[J]. J Dent Res, 2017, 96(11): 1290-1297.
12 冷沙, 黄定明, 高原, 等. 牛牙症的诊断与治疗[J]. 国际口腔医学杂志, 2019, 46(5): 509-515.
Leng S, Huang DM, Gao Y, et al. Diagnosis and treatment of taurodontism[J]. Int J Stomatol, 2019, 46(5): 509-515.
13 Lind V. Short root anomaly[J]. Scand J Dent Res, 1972, 80(2): 85-93.
14 Puranik CP, Hill A, Henderson Jeffries K, et al. Characterization of short root anomaly in a Mexican cohort: hereditary idiopathic root malformation[J]. Orthod Craniofac Res, 2015, 18(): 62-70.
15 Yu MJ, Jiang ZW, Wang Y, et al. Molecular mechanisms for short root anomaly[J]. Oral Dis, 2021, 27(2): 142-150.
16 Tananuvat N, Charoenkwan P, Ohazama A, et al. Root dentin anomaly and a PLG mutation[J]. Eur J Med Genet, 2014, 57(11/12): 630-635.
17 Kurtulus-Waschulewski I, Wahl G, Dittrich K, et al. Letter regarding the article: “root dentin anomaly and a PLG mutation” by Tananuvat et al[J]. Eur J Med Genet, 2015, 58(3): 199-200.
18 Cutrera A, Allareddy V, Azami N, et al. Is Short Root Anomaly (SRA) a risk factor for increased external apical root resorption in orthodontic patients? A retrospective case control study using cone beam computerized tomography[J]. Orthod Craniofac Res, 2019, 22(1): 32-37.
19 Topouzelis N, Tsaousoglou P, Pisoka V, et al. Dila-ceration of maxillary central incisor: a literature review[J]. Dent Traumatol, 2010, 26(5): 427-433.
20 Walia PS, Rohilla AK, Choudhary S, et al. Review of dilaceration of maxillary central incisor: a mutidisciplinary challenge[J]. Int J Clin Pediatr Dent, 2016, 9(1): 90-98.
21 Cao D, Shao BT, Izadikhah I, et al. Root dilaceration in maxillary impacted canines and adjacent teeth: a retrospective analysis of the difference between buccal and palatal impaction[J]. Am J Orthod Dentofacial Orthop, 2021, 159(2): 167-174.
22 Lee HS, Kim SH, Kim SO, et al. A new type of dental anomaly: molar-incisor malformation (MIM)[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 118(1): 101-109.e3.
23 Wright JT, Curran A, Kim KJ, et al. Molar root-incisor malformation: considerations of diverse developmental and etiologic factors[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 121(2): 164-172.
24 Brusevold IJ, Bie TMG, Baumgartner CS, et al. Molar incisor malformation in six cases: description and diagnostic protocol[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2017, 124(1): 52-61.
25 Charisi C, Kodonas K, Keklikoglou K, et al. Morphological, histological, and chemical analysis of first permanent molars with molar incisor malformation[J]. Eur Arch Paediatr Dent, 2022, 23(4): 601-608.
26 Kim MJ, Song JS, Kim YJ, et al. Clinical conside-rations for dental management of children with molar-root incisor malformations[J]. J Clin Pediatr Dent, 2020, 44(1): 55-59.
27 Witt CV, Hirt T, Rutz G, et al. Root malformation associated with a cervical mineralized diaphragm: a distinct form of tooth abnormality[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(4): e311-e319.
28 Lee HS, Kim SH, Kim SO, et al. Microscopic analysis of molar: incisor malformation[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2015, 119(5): 544-552.
29 Choi S, Lee J, Song J. Molar-incisor malformation: three cases of a newly identified dental anomaly[J]. J Korean Acad Pediatr Dent, 2017, 44(3): 370-377.
30 Vargo RJ, Reddy R, da Costa WB, et al. Molar-incisor malformation: eight new cases and a review of the literature[J]. Int J Paediatr Dent, 2020, 30(2): 216-224.
31 Neo HLL, Watt EN, Acharya P. Molar-incisor malformation: a case report and clinical considerations[J]. J Orthod, 2019, 46(4): 343-348.
32 Yue W, Kim E. Nonsurgical endodontic management of a molar-incisor malformation-affected mandibular first molar: a case report[J]. J Endod, 2016, 42(4): 664-668.
33 Shields ED, Bixler D, el-Kafrawy AM. A proposed classification for heritable human dentine defects with a description of a new entity[J]. Arch Oral Biol, 1973, 18(4): 543-553.
34 Chen D, Li X, Lu F, et al. Dentin dysplasia type Ⅰ -a dental disease with genetic heterogeneity[J]. Oral Dis, 2019, 25(2): 439-446.
35 Ye X, Li KY, Liu L, et al. Dentin dysplasia type Ⅰ- novel findings in deciduous and permanent teeth[J]. BMC Oral Health, 2015, 15: 163.
36 Wesley RK, Wysoki GP, Mintz SM, et al. Dentin dysplasia type Ⅰ. Clinical, morphologic, and genetic studies of a case[J]. Oral Surg Oral Med Oral Pathol, 1976, 41(4): 516-524.
37 Bloch-Zupan A, Jamet X, Etard C, et al. Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects[J]. Am J Hum Genet, 2011, 89(6): 773-781.
38 Yang Q, Chen D, Xiong F, et al. A splicing mutation in VPS4B causes dentin dysplasia Ⅰ[J]. J Med Ge-net, 2016, 53(9): 624-633.
39 Xiong F, Ji ZS, Liu YH, et al. Mutation in SSUH2 causes autosomal-dominant dentin dysplasia type I[J]. Hum Mutat, 2017, 38(1): 95-104.
40 Foster BL, Nagatomo KJ, Nociti FH Jr, et al. Central role of pyrophosphate in acellular cementum formation[J]. PLoS One, 2012, 7(6): e38393.
41 van den Bos T, Handoko G, Niehof A, et al. Cementum and dentin in hypophosphatasia[J]. J Dent Res, 2005, 84(11): 1021-1025.
42 Okawa R, Nakano K. Dental manifestation and ma-nagement of hypophosphatasia[J]. Jpn Dent Sci Rev, 2022, 58: 208-216.
43 Feeney C, Stanford N, Lee S, et al. Hypophosphatasia and the importance of the general dental practitioner-a case series and discussion of upcoming treatments[J]. Br Dent J, 2018, 224(12): 937-943.
44 Hollis A, Arundel P, High A, et al. Current concepts in hypophosphatasia: case report and literature review[J]. Int J Paediatr Dent, 2013, 23(3): 153-159.
45 Liu H, Li J, Lei H, et al. Genetic etiology and dental pulp cell deficiency of hypophosphatasia[J]. J Dent Res, 2010, 89(12): 1373-1377.
46 Alotaibi O, Alotaibi G, Alfawaz N. Regional odontodysplasia: an analysis of 161 cases from 1953 to 2017[J]. Saudi Dent J, 2019, 31(3): 306-310.
47 Silva Cunha JL, Barboza Santana AV, Alves da Mota Santana L, et al. Regional odontodysplasia affec-ting the maxilla[J]. Head Neck Pathol, 2020, 14(1): 224-229.
48 Jahanimoghadam F, Pishbin L, Clinical Rad M., radiographic, and histologic evaluation of regional odontodysplasia : a case report with 5-year follow-up[J]. J Dent (Shiraz), 2016, 17(2): 159-163.
49 Hamdan MA, Sawair FA, Rajab LD, et al. Regional odontodysplasia: a review of the literature and report of a case[J]. Int J Paediatr Dent, 2004, 14(5): 363-370.
50 Koruyucu M, Yaman D, Seymen F, et al. Management of regional odontodysplasia: a 10-year-follow-up case report and literature review[J]. Eur Oral Res, 2018, 52(2): 111-116.
51 Hess P, Lauridsen EF, Daugaard-Jensen J, et al. Treatment strategies for patients with regional odontodysplasia: a presentation of seven new cases and a review of the literature[J]. Oral Health Prev Dent, 2020, 18(1): 669-681.
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