国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 432-440.doi: 10.7518/gjkq.2022055

• 综述 • 上一篇    下一篇

牙周炎相关基因多态性的研究进展

周佳佳1(),赵蕾2,徐欣1()   

  1. 1.口腔疾病研究国家重点实验室;国家口腔疾病临床医学研究中心;四川大学华西口腔医院牙体牙髓病科 成都 610041
    2.口腔疾病研究国家重点实验室;国家口腔疾病临床医学研究中心;四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2021-11-29 修回日期:2022-03-10 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 徐欣
  • 作者简介:周佳佳，硕士，Email：412070261@qq.com
  • 基金资助:
    国家自然科学基金(81771099);四川大学华西口腔医院临床队列研究项目(LCYJ2019-4)

Research progress on the genetic polymorphism of periodontitis

Zhou Jiajia1(),Zhao Lei2,Xu Xin1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Di-seases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomato-logy, Sichuan University, Chengdu 610041, China
  • Received:2021-11-29 Revised:2022-03-10 Online:2022-07-01 Published:2022-06-28
  • Contact: Xin Xu
  • Supported by:
    National Natural Science Foundation of China(81771099);Clinical Cohort Study Project of West China Hospital of Stomatology, Sichuan University(LCYJ2019-4)

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摘要：

牙周炎是由微生物、遗传和环境因素共同作用引发的慢性感染性疾病。宿主基因多态性可影响宿主固有免疫的水平，调控微生物群落组成与结构，在牙周炎的发生发展及预后中有重要作用。牙周炎遗传易感性的早期研究主要集中在与牙周炎发生发展有关的细胞因子、趋化因子、代谢调节因子以及与先天性和获得性免疫反应相关的蛋白质的单核苷酸多态性。随着人类基因组计划的完成和高通量基因测序技术的发展，全基因组关联分析成为研究牙周炎遗传变异的有效策略，后全基因组关联分析进一步采用新的统计学方法深入挖掘牙周炎的遗传学机制。本文围绕单核苷酸多态性分析、全基因组关联分析和后全基因组关联分析在牙周炎遗传易感性领域的进展进行综述，旨在从易感基因角度为牙周炎高危人群的重点防治提供思路。

关键词: 牙周炎, 易感性, 单核苷酸多态性, 全基因组关联分析, 固有免疫

Abstract:

Periodontitis is a chronic infectious disease resulting from the complex interaction among microbial, genetic, and environmental factors. Genetic polymorphisms that affect host innate immune and regulate the structure of the microbial community have been implicated in the development and prognosis of periodontitis. Early studies on genetic susceptibility of periodontitis have focused on single-nucleotide polymorphisms of cytokines, chemokines, metabolic regulators, and proteins of innate and acquired immune responses associated with the development of periodontitis. With the completion of the Human Genome Project and the development of high-throughput sequencing technology, the genome-wide association study has become an effective strategy to study genetic variation in periodontitis. In addition, the post genome-wide association study applied new statistical methods to identify more genetic mechanisms of periodontitis. This review summarized the progress on the genetic susceptibility of periodontitis obtained from single-nucleotide polymorphism, genome-wide association, and post-genome-wide association studies to advance the knowledge on periodontal high-risk po-pulation precision management from the genetic polymorphism perspective.

Key words: periodontitis, susceptibility, single nucleo-tide polymorphism, genome wide association study, innate immune

中图分类号: 

  • R 781.4
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