国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 441-447.doi: 10.7518/gjkq.2022081

• 综述 • 上一篇    下一篇

维生素D与药物相关性颌骨坏死关系的研究进展

戢晓(),朱桂全()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院头颈肿瘤外科 成都 610041
  • 收稿日期:2022-01-17 修回日期:2022-04-02 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 朱桂全
  • 作者简介:戢晓，学士，Email：jixiao08@126.com
  • 基金资助:
    四川省科学技术厅中央引导地方科技发展专项(2020ZYD033)

Research progress on the relationship between vitamin D and medication-related osteonecrosis of the jaw

Ji Xiao(),Zhu Guiquan.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-01-17 Revised:2022-04-02 Online:2022-07-01 Published:2022-06-28
  • Contact: Guiquan. Zhu
  • Supported by:
    Central Guidance for Local Science and Technology Development Projects of Science and Technology Department of Sichuan Province(2020ZYD033)

RichHTML

96

PDF (PC)

544

摘要：

药物相关性颌骨坏死（MRONJ）是抗骨吸收药物和抗血管生成药物使用过程中或使用后出现的一种药物不良反应，主要临床表现为颌骨坏死。MRONJ的危险因素众多，但确切发病机制目前尚未明确，尚无有效的治疗手段。维生素D与口腔健康乃至全身健康都密切相关，近年来，维生素D与MRONJ的关系逐渐受到关注。MRONJ的发生可能与维生素D缺乏有关，MRONJ的高危人群与维生素D水平缺乏的人群存在重合现象，MRONJ的发病机制可能涉及相关药物和维生素D缺乏相互作用导致的机体骨钙平衡失调和免疫功能受损。补充维生素D可能是防治MRONJ的有效手段。本文就维生素D与MRONJ关系的研究进展进行综述。

关键词: 药物相关性颌骨坏死, 维生素D, 双膦酸盐

Abstract:

Medication-related osteonecrosis of the jaw (MRONJ) is a complication during or after the use of antiresorptive or antiangiogenic agents. It has many risk factors, but the specific pathogenesis and effective treatment remain unclear. Vitamin D is closely related to oral and systemic health, and recent research has focused on the relationship between vitamin D and MRONJ. Studies found that the occurrence of MRONJ may be related to vitamin D deficiency. The high-risk populations for MRONJ appear to overlap with those with inadequate vitamin D levels. Moreover, the mechanism of MRONJ may involve the interaction of related drugs and vitamin D deficiency in the damage process of calcium homeostasis and immune function. Therefore, vitamin D may be effective means of combating MRONJ. This article reviewed the recent research progress on the relationship between vitamin D and MRONJ.

Key words: medication-related osteonecrosis of the jaw, vitamin D, bisphosphonates

中图分类号: 

  • R 78
1 Ruggiero SL, Dodson TB, Fantasia J, et al. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw: 2014 update[J]. J Oral Maxillofac Surg, 2014, 72(10): 1938-1956.
2 Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws[J]. J Oral Maxillofac Surg, 2007, 65(3): 369-376.
3 苏程, 王泽坤, 骆南羽, 等. 药物相关性颌骨坏死的研究进展[J]. 国际口腔医学杂志, 2017, 44(2): 228-234.
Su C, Wang ZK, Luo NY, et al. Research progress on medication-related osteonecrosis of the jaw[J]. Int J Stomatol, 2017, 44(2): 228-234.
4 Lorenzo-Pouso AI, Pérez-Sayáns M, García A, et al. Vitamin D supplementation: hypothetical effect on medication-related osteonecrosis of the jaw[J]. Med Hypotheses, 2018, 116: 79-83.
5 郭陟永, 刘济远, 李春洁, 等. 药物相关性颌骨坏死发病机制的研究进展[J]. 国际口腔医学杂志, 2020, 47(6): 717-724.
Guo ZY, Liu JY, Li CJ, et al. Research progress on the pathogenesis of medication-related osteonecrosis of the jaw[J]. Int J Stomatol, 2020, 47(6): 717-724.
6 Sim IW, Borromeo GL, Tsao C, et al. Teriparatide promotes bone healing in medication-related osteonecrosis of the jaw: a placebo-controlled, rando-mized trial[J]. J Clin Oncol, 2020, 38(26): 2971-2980.
7 Cha YH, Hong N, Rhee Y, et al. Teriparatide therapy for severe, refractory osteoradionecrosis of the jaw[J]. Osteoporos Int, 2018, 29(4): 987-992.
8 姜钧健, 何悦. 药物相关性颌骨坏死治疗方法的研究进展[J]. 中国口腔颌面外科杂志, 2020, 18(5): 474-477.
Jiang JJ, He Y. Research progress on treatment of medication-related osteonecrosis of the jaw[J]. China J Oral Maxillofac Surg, 2020, 18(5): 474-477.
9 Leizaola-Cardesa IO, Aguilar-Salvatierra A, Gonzalez-Jaranay M, et al. Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link[J]. Med Oral Patol Oral Cir Bucal, 2016, 21(2): e236-e240.
10 Ma SL, Tian XY, Wang YQ, et al. Vitamin D supplementation prevents placental ischemia induced endothelial dysfunction by downregulating placental soluble FMS-like tyrosine kinase-1[J]. DNA Cell Biol, 2017, 36(12): 1134-1141.
11 Brüggmann D, Alafi A, Jaque J, et al. World-wide research architecture of vitamin D research: density-equalizing mapping studies and socio-economic ana-lysis[J]. Nutr J, 2018, 17(1): 3.
12 廖祥鹏, 张增利, 张红红, 等. 维生素D与成年人骨骼健康应用指南(2014年标准版)[J]. 中国骨质疏松杂志, 2014, 20(9): 1011-1030.
Liao XP, Zhang ZL, Zhang HH, et al. Application guideline for vitamin D and bone health in adult Chinese (2014 standard edition)[J]. Chin J Osteopor, 2014, 20(9): 1011-1030.
13 Holick MF. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention[J]. Rev Endocr Metab Disord, 2017, 18(2): 153-165.
14 Grant WB, Boucher BJ. Randomized controlled trials of vitamin D and cancer incidence: a modeling study[J]. PLoS One, 2017, 12(5): e0176448.
15 Dalle Carbonare L, Mottes M, Valenti MT. Medication-related osteonecrosis of the jaw (MRONJ): are antiresorptive drugs the main culprits or only accomplices? the triggering role of vitamin D deficiency[J]. Nutrients, 2021, 13(2): 561.
16 陈俊敏. 二磷酸盐（唑来膦酸）治疗骨质疏松症引起不良反应与维生素D的相关性[D]. 银川: 宁夏医科大学, 2019.
Chen JM. Correlation between vitamin D and adverse reactions induced by diphosphate (zoledronic acid) in the treatment of osteoporosis[D]. Yinchuan: Ningxia Medical University, 2019.
17 Demircan S, Isler SC. Changes in serological bone turnover markers in bisphosphonate induced osteonecrosis of the jaws: a case control study[J]. Niger J Clin Pract, 2020, 23(2): 154-158.
18 Heim N, Warwas FB, Wilms CT, et al. Vitamin D (25-OHD) deficiency may increase the prevalence of medication-related osteonecrosis of the jaw[J]. J Craniomaxillofac Surg, 2017, 45(12): 2068-2074.
19 Lowe LC, Guy M, Mansi JL, et al. Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population[J]. Eur J Cancer, 2005, 41(8): 1164-1169.
20 Badros A, Goloubeva O, Terpos E, et al. Prevalence and significance of vitamin D deficiency in multiple myeloma patients[J]. Br J Haematol, 2008, 142(3): 492-494.
21 Martelli FS, Martelli M, Rosati C, et al. Vitamin D: relevance in dental practice[J]. Clin Cases Miner Bone Metab, 2014, 11(1): 15-19.
22 Hokugo A, Christensen R, Chung EM, et al. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats[J]. J Bone Miner Res, 2010, 25(6): 1337-1349.
23 Anderson PH, Sawyer RK, Moore AJ, et al. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model[J]. J Bone Miner Res, 2008, 23(11): 1789-1797.
24 Hakim SG, Bruecker CW, HChJacobsen, et al. The value of FDG-PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible[J]. Int J Oral Maxillofac Surg, 2006, 35(9): 809-816.
25 Liu PT, Stenger S, Li HY, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J]. Science, 2006, 311(5768): 1770-1773.
26 Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 [J]. FASEB J, 2005, 19(9): 1067-1077.
27 Hansen TH, Madsen MTB, Jørgensen NR, et al. Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans[J]. Eur J Clin Nutr, 2018, 72(7): 1046-1054.
28 Fan JX, Li N, Gong XF, et al. Serum 25-hydroxyvitamin D, bone turnover markers and bone mineral density in postmenopausal women with hip fractures[J]. Clin Chim Acta, 2018, 477: 135-140.
29 Kim WW, Chung SH, Ban EJ, et al. Is preoperative vitamin D deficiency a risk factor for postoperative symptomatic hypocalcemia in thyroid cancer patients undergoing total thyroidectomy plus central compartment neck dissection[J]. Thyroid, 2015, 25(8): 911-918.
30 Lyles KW, Colón-Emeric CS, Magaziner JS, et al. Zoledronic acid and clinical fractures and mortality after hip fracture[J]. N Engl J Med, 2007, 357(18): 1799-1809.
31 Michalak F, Hnitecka S, Dominiak M, et al. Schemes for drug-induced treatment of osteonecrosis of jaws with particular emphasis on the influence of vitamin D on therapeutic effects[J]. Pharmaceutics, 2021, 13(3): 354.
32 Ardine M, Generali D, Donadio M, et al. Could the long-term persistence of low serum calcium levels and high serum parathyroid hormone levels during bisphosphonate treatment predispose metastatic brea-st cancer patients to undergo osteonecrosis of the jaw[J]. Ann Oncol, 2006, 17(8): 1336-1337.
33 Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity[J]. Nat Clin Pract Endocrinol Metab, 2008, 4(2): 80-90.
34 康壮飞. 唑来膦酸对颌骨影响的基因差异分析[D]. 石家庄: 河北医科大学, 2016.
Kang ZF. The effect of mandibule on gene differential expression after using zoledronic acid[D]. Shijia-zhuang: Hebei Medical University, 2016.
35 陶船思博, 梅芳, 钟金晟. 滤泡样树突细胞分泌蛋白的自然免疫作用和在口腔组织中的表达[J]. 国际口腔医学杂志, 2014, 41(4): 444-447.
Tao CSB, Mei F, Zhong JS. Innate immune effect and its expression level in oral tissues of follicular dendritic cells secreted protein[J]. Int J Stomatol, 2014, 41(4): 444-447.
36 Hamadeh IS, Ngwa BA, Gong Y. Drug induced osteonecrosis of the jaw[J]. Cancer Treat Rev, 2015, 41(5): 455-464.
37 Yazdi PM, Schiodt M. Dentoalveolar trauma and minor trauma as precipitating factors for medication-related osteonecrosis of the jaw (ONJ): a retrospective study of 149 consecutive patients from the Copenhagen ONJ Cohort[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2015, 119(4): 416-422.
38 Li H, Li B, Wang Q, et al. Attenuation of inflammatory response by 25- hydroxyvitamin D3-loaded po-lylactic acid microspheres in treatment of periodontitis in diabetic rats[J]. Chin J Dent Res, 2014, 17(2): 91-98.
39 Ramos-Martínez E, López-Vancell MR, Fernández de Córdova-Aguirre JC, et al. Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression[J]. Cytokine, 2018, 108: 239-246.
40 Saito M, Grynpas MD, Burr DB, et al. Treatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone[J]. Bone, 2015, 73: 8-15.
41 Catalano A, Morabito N, Atteritano M, et al. Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis[J]. Calcif Tissue Int, 2012, 90(4): 279-285.
42 Xiong ZH, Wu JY, Liu ZJ, et al. Moderate osteoporosis itself is beneficial for bones[J]. Med Hypotheses, 2020, 134: 109427.
43 Koster JC, Hackeng WH, Mulder H. Diminished effect of etidronate in vitamin D deficient osteopenic postmenopausal women[J]. Eur J Clin Pharmacol, 1996, 51(2): 145-147.
44 Soares AL, Simon S, Gebrim LH, et al. Prevalence and risk factors of medication-related osteonecrosis of the jaw in osteoporotic and breast cancer patients: a cross-sectional study[J]. Support Care Cancer, 2020, 28(5): 2265-2271.
[1] 郭陟永,刘济远,李春洁,唐休发. 药物相关性颌骨坏死发病机制的研究进展[J]. 国际口腔医学杂志, 2020, 47(6): 717-724.
[2] 苏程,王泽坤,骆南羽,唐华. 药物相关性颌骨坏死的研究进展[J]. 国际口腔医学杂志, 2017, 44(2): 228-234.
[3] 魏斌，孙国文. 双膦酸盐及其相关性颌骨坏死的机制和治疗[J]. 国际口腔医学杂志, 2016, 43(4): 445-448.
[4] 仝春实1 邹永巍1 王雷1 宫俊霞2 李文然1 刘长欢1 卢建忠1. 维生素D及其与牙周炎的关系[J]. 国际口腔医学杂志, 2014, 41(4): 474-477.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .