国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 441-447.doi: 10.7518/gjkq.2022081
摘要:
药物相关性颌骨坏死(MRONJ)是抗骨吸收药物和抗血管生成药物使用过程中或使用后出现的一种药物不良反应,主要临床表现为颌骨坏死。MRONJ的危险因素众多,但确切发病机制目前尚未明确,尚无有效的治疗手段。维生素D与口腔健康乃至全身健康都密切相关,近年来,维生素D与MRONJ的关系逐渐受到关注。MRONJ的发生可能与维生素D缺乏有关,MRONJ的高危人群与维生素D水平缺乏的人群存在重合现象,MRONJ的发病机制可能涉及相关药物和维生素D缺乏相互作用导致的机体骨钙平衡失调和免疫功能受损。补充维生素D可能是防治MRONJ的有效手段。本文就维生素D与MRONJ关系的研究进展进行综述。
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