国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 277-281.doi: 10.7518/gjkq2019036
闫冰1,2,3,骆献阳1,2,3,谭迎赟4,关丽梅1,薛丽丽5()
Bing Yan1,2,3,Xianyang Luo1,2,3,Yingyun Tan4,Limei Guan1,Lili Xue5()
摘要:
目的 应用表面增强拉曼光谱技术研究口腔鳞状细胞癌患者血清,并建立临床分期鉴别诊断模型。方法 收集144例口腔鳞状细胞癌患者血清,按照早期组、中期组及晚期组进行分组检测血清表面增强拉曼光谱,比较光谱差异,应用主成分分析法及线性判别函数法建立鉴别诊断模型,对不同分组光谱数据进行鉴别诊断。结果 共获得血清拉曼光谱144例,其中早期组59例,中期组40例及晚期组45例。血清光谱差异主要表现在721~727、931~932 、1 129~1 133、1 264~1 266、1 367~1 371 cm -1处谱峰强度差异,主要与血清中脂类、蛋白质及核酸成分和结构有关。鉴别诊断模型总体准确率达80%以上,经过交互验证后准确率为70%以上。结论 表面增强拉曼光谱检测口腔鳞状细胞癌患者血清为口腔鳞状细胞癌临床分期及预后判断提供了一种简便、准确的新方法。
中图分类号:
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