国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (3): 314-320.doi: 10.7518/gjkq.2023043

• 综述 • 上一篇    下一篇

性别决定基因盒9在口腔鳞状细胞癌作用机制和治疗中的研究进展

盛南宁1,2(),王珏1,3(),南欣荣1,4   

  1. 1.山西医科大学口腔医学院 太原 030001
    2.口腔疾病防治与新材料山西省重点实验室 太原 030001
    3.山西医科大学第一医院口腔修复科 太原 030001
    4.山西医科大学第一医院口腔颌面外科 太原 030001
  • 收稿日期:2022-09-15 修回日期:2023-02-27 出版日期:2023-05-01 发布日期:2023-05-16
  • 通讯作者: 王珏
  • 作者简介:盛南宁，医师，硕士，Email：sheng_415@163.com
  • 基金资助:
    国家自然科学基金(82003146)

Research progress on mechanism and treatment of sex-determining region Y box 9 in oral squamous cell carcinoma

Sheng Nanning1,2(),Wang Jue1,3(),Nan Xinrong1,4   

  1. 1.School of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2.Shanxi Province Key Laboratory of Oral Disease Prevention and New Materials, Taiyuan 030001, China
    3.Dept. of Prosthodontics, First Hospital of Shanxi Medical University, Taiyuan 030001, China
    4.Dept. of Oral and Maxillofacial Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2022-09-15 Revised:2023-02-27 Online:2023-05-01 Published:2023-05-16
  • Contact: Jue Wang
  • Supported by:
    National Natural Science Foundation of China(82003146)

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摘要：

口腔鳞状细胞癌（OSCC）是头颈部常见的恶性肿瘤，预后较差，生存率长期未见提高。性别决定基因盒9（SOX9）在全身各个系统的恶性肿瘤均有表达，已成为肿瘤表面标志物及靶向治疗方面的研究热点。在OSCC中，SOX9的作用复杂多样，可能通过诱导化疗耐药等干细胞特征的产生导致不良预后。了解其在OSCC发生发展及治疗预后中的具体作用及机制有助于早日攻克OSCC预后生存难题。本文就SOX9在OSCC的早期诊断和预防、发生发展中的作用和机制以及对治疗预后的影响等方面进行综述。

关键词: 性别决定基因盒9, 口腔鳞状细胞癌, 肿瘤表面标志物

Abstract:

Oral squamous cell carcinoma is the most common malignancy of the head and neck. It has poor prognosis and survival rate that has not improved for many years. Sex-determining region Y box 9 (SOX9) is expressed in malignant tumors of various systems throughout the body. In recent years, SOX9 has become a hotspot in research on tumor surface markers and tumor-targeted therapy. In oral squamous cell carcinoma, SOX9 exhibits complex and diverse effects and may lead to poor prognosis by inducing the development of stem cell features, such as chemotherapy resistance. Understanding the specific role and mechanism of SOX9 in the occurrence, development, and prognosis of OSCC is important to improve the prognosis and survival of oral squamous cell carcinoma. In this paper, the role and mechanism of SOX9 in the early diagnosis, prevention, occurrence, development, and treatment prognosis of oral squamous cell carcinoma are discussed.

Key words: sex-determining region Y box 9, oral squamous cell carcinoma, tumor surface marker

中图分类号: 

  • R 739.8
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