国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 462-470.doi: 10.7518/gjkq.2022044

• 综述 • 上一篇    下一篇

光热治疗在口腔鳞状细胞癌治疗中的研究进展

赵卓平1(),辛鹏飞2,3,高阳2,3,张彩凤4,张宽收5,刘青梅1,2,3()   

  1. 1.山西医科大学口腔医学院·口腔医院 太原 030001
    2.山西医科大学第三医院（山西白求恩医院 山西医学科学院 同济山西医院）口腔科 太原 030032
    3.华中科技大学同济医学院附属同济医院 武汉 430030
    4.太原师范学院化学系 山西省腐植酸工程技术研究中心 晋中 030619
    5.山西大学量子光学与光量子器件国家重点实验室;山西大学光电研究所极端光学协同创新中心 太原 030006
  • 收稿日期:2021-11-01 修回日期:2022-03-12 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 刘青梅
  • 作者简介:赵卓平，硕士，Email：784246283@qq.com
  • 基金资助:
    山西省卫生健康委员会科研课题(2018017);山西省“1331工程”协同创新中心建设计划项目;量子光学与光量子器件国家重点实验室（山西大学）开放课题(KF202105)

Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma

Zhao Zhuoping1(),Xin Pengfei2,3,Gao Yang2,3,Zhang Caifeng4,Zhang Kuanshou5,Liu Qingmei1,2,3()   

  1. 1.Shanxi Medical University, School and Hospital of Stomatology, Taiyuan 030001, China
    2.Dept of Stomatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
    3.Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    4.Dept. of Chemistry, Taiyuan Normal University, Shanxi Humic Acid Engineering Technology Research Center, Jinzhong 030619, China
    5.State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China
  • Received:2021-11-01 Revised:2022-03-12 Online:2022-07-01 Published:2022-06-28
  • Contact: Qingmei Liu
  • Supported by:
    Scientific Research Project of Health Commission of Shanxi Province(2018017);Fund for Shanxi “1331 Project” Collaborative Innovation Center, and Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices (Shanxi University)(KF202105)

RichHTML

55

PDF (PC)

1080

摘要：

目前，对于口腔鳞状细胞癌（OSCC）临床应用和研究较多的治疗手段主要包括手术、放射治疗、化学治疗、传统热疗、基因疗法、免疫疗法和光动力疗法（PDT）等，但治疗效果有限并伴有不同程度的不良反应。光热治疗（PTT）是一种新型的治疗方法，通过光热效应选择性杀伤癌细胞，具有较高的安全性。近红外光（NIR）具有良好的组织穿透性，光热转换剂（PTCA）具有可修饰性和选择性，它们是光热治疗的两大要素。通过构建纳米载体平台，PTT可协同增强其他治疗手段的疗效并降低不良反应。本文对OSCC的治疗现状、PTT的光热转换原理及在OSCC的治疗等方面进行综述，旨在为PTT在OSCC中的治疗提供理论依据。

关键词: 口腔鳞状细胞癌, 光热治疗, 光热效应, 近红外光, 光热转换剂

Abstract:

At present, the most clinically applied and researched treatments for oral squamous cell carcinoma (OSCC) mainly include surgery, radiotherapy, chemotherapy, traditional hyperthermia, gene therapy, immunotherapy, and photodynamic therapy. However, the therapeutic effect of these treatments is limited and often accompanied by varying degrees of side effects. Photothermal therapy (PTT) is a novel type of treatment method that can selectively kill cancer cells through photothermal effect with high safety. The two elements of PTT are near infrared with good tissue penetration and photothermal conversion agents with modifiability and selectivity. By building nanocar-rier platforms, PTT can synergistically enhance the efficacy of other therapies and reduce their side effects. In this paper, the current treatment status of OSCC, the photothermal conversion principle of PTT, and its application in the treatment of OSCC were reviewed to provide a theoretical basis for the treatment of OSCC using PTT.

Key words: oral squamous cell carcinoma, photothermal therapy, photothermal effect, near infrared, photothermal conversion agent

中图分类号: 

  • R 739.81
1 Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424.
2 Neville BW, Day TA. Oral cancer and precancerous lesions[J]. CA Cancer J Clin, 2002, 52(4): 195-215.
3 Fan HY, Zhu ZL, Zhang WL, et al. Light stimulus responsive nanomedicine in the treatment of oral squamous cell carcinoma[J]. Eur J Med Chem, 2020, 199: 112394.
4 Fan WP, Yung B, Huang P, et al. Nanotechnology for multimodal synergistic cancer therapy[J]. Chem Rev, 2017, 117(22): 13566-13638.
5 Cramer JD, Burtness B, Le QT, et al. The changing therapeutic landscape of head and neck cancer[J]. Nat Rev Clin Oncol, 2019, 16(11): 669-683.
6 Turner L, Mupparapu M, Akintoye SO. Review of the complications associated with treatment of oropharyngeal cancer: a guide for the dental practitioner[J]. Quintessence Int, 2013, 44(3): 267-279.
7 Petrovic I, Rosen EB, Matros E, et al. Oral rehabilitation of the cancer patient: a formidable challenge[J]. J Surg Oncol, 2018, 117(8): 1729-1735.
8 Kubota K, Kobayashi W, Sakaki H, et al. Professio-nal oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer[J]. Support Care Cancer, 2015, 23(11): 3323-3329.
9 Dirix P, Nuyts S, van den Bogaert W. Radiation-induced xerostomia in patients with head and neck cancer: a literature review[J]. Cancer, 2006, 107(11): 2525-2534.
10 Cha YH, Hong N, Rhee Y, et al. Teriparatide therapy for severe, refractory osteoradionecrosis of the jaw[J]. Osteoporos Int, 2018, 29(4): 987-992.
11 Furness S, Glenny AM, Worthington HV, et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy[J]. Cochrane Database Syst Rev, 2011(4): CD006386.
12 Zanoni DK, Montero PH, Migliacci JC, et al. Survival outcomes after treatment of cancer of the oral cavity (1985-2015)[J]. Oral Oncol, 2019, 90: 115-121.
13 Rogers SN, Brown JS, Woolgar JA, et al. Survival following primary surgery for oral cancer[J]. Oral Oncol, 2009, 45(3): 201-211.
14 Sousa AA, Caldeira PC, da Silva KD, et al. Survival analysis of recurrent squamous cell carcinoma of the lower oral cavity treated by surgery[J]. Int J Clin Exp Pathol, 2021, 14(6): 713-719.
15 D’Cruz AK, Vaish R, Dhar H. Oral cancers: current status[J]. Oral Oncol, 2018, 87: 64-69.
16 Tam S, Araslanova R, Low TH, et al. Estimating survival after salvage surgery for recurrent oral cavity cancer[J]. JAMA Otolaryngol Head Neck Surg, 2017, 143(7): 685-690.
17 Datta NR, Ordóñez SG, Gaipl US, et al. Local hyperthermia combined with radiotherapy and-/ or chemotherapy: recent advances and promises for the future[J]. Cancer Treat Rev, 2015, 41(9): 742-753.
18 Jin MY, Fu JL, Lu JB, et al. Ultrasound-guided percutaneous microwave ablation of parotid gland adenolymphoma: a case report[J]. Medicine (Baltimore), 2019, 98(35): e16757.
19 Fan HX, Li HX, Liu GY, et al. Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts[J]. J Exp Clin Cancer Res, 2017, 36(1): 163.
20 Ju HY, Mao L, Zhang LM, et al. Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF-mediated pathway[J]. J Oral Pathol Med, 2018, 47(10): 964-971.
21 Palumbo MN, Cervantes O, Eugênio C, et al. Intratumor cisplatin nephrotoxicity in combined laser-induced thermal therapy for cancer treatment[J]. Lasers Surg Med, 2017, 49(8): 756-762.
22 Cohen EEW, Soulières D, Le Tourneau C, et al. Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study[J]. Lancet, 2019, 393(10167): 156-167.
23 Bauml JM, Cohen RB, Aggarwal C. Immunotherapy for head and neck cancer: latest developments and clinical potential[J]. Ther Adv Med Oncol, 2016, 8(3): 168-175.
24 Alexander-Bryant AA, Zhang HW, Attaway CC, et al. Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo [J]. Oral Oncol, 2017, 72: 123-131.
25 Liu S, Chen P, Hu M, et al. Randomized, controlled phase Ⅱ study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer[J]. Cancer Gene Ther, 2013, 20(6): 375-378.
26 Li Y, Li LJ, Wang LJ, et al. Selective intra-arterial infusion of rAd-p53 with chemotherapy for advanced oral cancer: a randomized clinical trial[J]. BMC Med, 2014, 12: 16.
27 Adashi EY, Cohen IG. Therapeutic germline edi-ting: sense and sensibility[J]. Trends Genet, 2020, 36(5): 315-317.
28 Johansen A, Christensen SJ, Scheie D, et al. Neuromuscular adverse events associated with anti-PD-1 monoclonal antibodies: systematic review[J]. Neurology, 2019, 92(14): 663-674.
29 Postow MA, Sidlow R, Hellmann MD. Immune-related adverse events associated with immune checkpoint blockade[J]. N Engl J Med, 2018, 378(2): 158-168.
30 Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy-mechanisms, photosensitizers and combinations[J]. Biomed Pharmacother, 2018, 106: 1098-1107.
31 Toratani S, Tani R, Kanda T, et al. Photodynamic therapy using Photofrin and excimer dye laser treatment for superficial oral squamous cell carcinomas with long-term follow up[J]. Photodiagnosis Photodyn Ther, 2016, 14: 104-110.
32 Saini R, Lee NV, Liu KY, et al. Prospects in the application of photodynamic therapy in oral cancer and premalignant lesions[J]. Cancers (Basel), 2016, 8(9): 83-97.
33 Sun T, Dou JH, Liu S, et al. Second near-infrared conjugated polymer nanoparticles for photoacoustic imaging and photothermal therapy[J]. ACS Appl Mater Interfaces, 2018, 10(9): 7919-7926.
34 Liu YJ, Bhattarai P, Dai ZF, et al. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer[J]. Chem Soc Rev, 2019, 48(7): 2053-2108.
35 Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo [J]. Adv Drug Deliv Rev, 2013, 65(1): 71-79.
36 Feng W, Han XG, Wang RY, et al. Nanocatalysts-augmented and photothermal-enhanced tumor-specific sequential nanocatalytic therapy in both NIR-Ⅰ and NIR-Ⅱ biowindows[J]. Adv Mater, 2019, 31(5): e1805919.
37 Brongersma ML, Halas NJ, Nordlander P. Plasmon-induced hot carrier science and technology[J]. Nat Nanotechnol, 2015, 10(1): 25-34.
38 Agrawal A, Cho SH, Zandi O, et al. Localized surface plasmon resonance in semiconductor nanocrystals[J]. Chem Rev, 2018, 118(6): 3121-3207.
39 Afifi MM, El Sheikh SM, Abdelsalam MM, et al. Therapeutic efficacy of plasmonic photothermal nan-oparticles in hamster buccal pouch carcinoma[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 115(6): 743-751.
40 MacKey MA, Ali MR, Austin LA, et al. The most effective gold nanorod size for plasmonic photothermal therapy: theory and in vitro experiments[J]. J Phys Chem B, 2014, 118(5): 1319-1326.
41 Yang Y, Zhang QR, Cai MJ, et al. Size-dependent transmembrane transport of gold nanocages[J]. ACS Omega, 2020, 5(17): 9864-9869.
42 Yang NL, Cheng HF, Liu XZ, et al. Amorphous/crystalline hetero-phase Pd nanosheets: one-pot synthesis and highly selective hydrogenation reaction[J]. Adv Mater, 2018, 30(39): e1803234.
43 Kumar A, Mohammadi MM, Swihart MT. Synthesis, growth mechanisms, and applications of palladium-based nanowires and other one-dimensional nan-ostructures[J]. Nanoscale, 2019, 11(41): 19058-19085.
44 Lin M, Wang DD, Liu SW, et al. Cupreous complex-loaded chitosan nanoparticles for photothermal the-rapy and chemotherapy of oral epithelial carcinoma[J]. ACS Appl Mater Interfaces, 2015, 7(37): 20801-20812.
45 Tian QW, Jiang FR, Zou RJ, et al. Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo [J]. ACS Nano, 2011, 5(12): 9761-9771.
46 Hu CL, Zhang ZX, Liu SN, et al. Monodispersed CuSe sensitized covalent organic framework photosensitizer with an enhanced photodynamic and photothermal effect for cancer therapy[J]. ACS Appl Mater Interfaces, 2019, 11(26): 23072-23082.
47 Chen YJ, Khan AR, Yu DX, et al. Pluronic F127-functionalized molybdenum oxide nanosheets with pH-dependent degradability for chemo-photothermal cancer therapy[J]. J Colloid Interface Sci, 2019, 553: 567-580.
48 Liu Z, Liu JH, Wang R, et al. An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract[J]. Biomaterials, 2015, 56: 206-218.
49 Zhang LP, Ran JR, Qiao SZ, et al. Characterization of semiconductor photocatalysts[J]. Chem Soc Rev, 2019, 48(20): 5184-5206.
50 Wang SG, Chen Y, Li X, et al. Injectable 2D MoS2-integrated drug delivering implant for highly efficient NIR-triggered synergistic tumor hyperthermia[J]. Adv Mater, 2015, 27(44): 7117-7122.
51 Liu J, Zheng XP, Yan L, et al. Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor[J]. ACS Nano, 2015, 9(1): 696-707.
52 Wang Y, Zhao JX, Chen Z, et al. Construct of MoSe2/Bi2Se3 nanoheterostructure: multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer tre-ating[J]. Biomaterials, 2019, 217: 119282.
53 Jia XD, Bai J, Ma ZF, et al. BSA-exfoliated WSe2 nanosheets as a photoregulated carrier for synergistic photodynamic/photothermal therapy[J]. J Mater Chem B, 2017, 5(2): 269-278.
54 You J, Heo JS, Kim J, et al. Noninvasive photodetachment of stem cells on tunable conductive polymer nano thin films: selective harvesting and preserved differentiation capacity[J]. ACS Nano, 2013, 7(5): 4119-4128.
55 Li XZ, Liu L, Li SL, et al. Biodegradable π-conjugated oligomer nanoparticles with high photothermal conversion efficiency for cancer theranostics[J]. ACS Nano, 2019, 13(11): 12901-12911.
56 Liang C, Diao S, Wang C, et al. Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes[J]. Adv Mater, 2014, 26(32): 5646-5652.
57 Chung S, Revia RA, Zhang MQ. Graphene quantum dots and their applications in bioimaging, biosensing, and therapy[J]. Adv Mater, 2021, 33(22): e1904362.
58 Chung YJ, Kim J, Park CB. Photonic carbon dots as an emerging nanoagent for biomedical and healthcare applications[J]. ACS Nano, 2020, 14(6): 6470-6497.
59 Shan WJ, Chen RH, Zhang Q, et al. Improved stable indocyanine green (ICG)-mediated cancer optothe-ranostics with naturalized hepatitis B core particles[J]. Adv Mater, 2018, 30(28): e1707567.
60 He WX, Jiang Y, Li Q, et al. A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: a case of an IR-780 derivative co-assembled with camptothecin prodrug[J]. Acta Biomater, 2019, 84: 356-366.
61 Zhou J, Lu ZG, Zhu XJ, et al. NIR photothermal therapy using polyaniline nanoparticles[J]. Biomaterials, 2013, 34(37): 9584-9592.
62 Yang K, Xu H, Cheng L, et al. In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles[J]. Adv Mater, 2012, 24(41): 5586-5592.
63 Zhang C, Zheng DW, Li CX, et al. Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor[J]. Biomaterials, 2019, 223: 119472.
64 Miao ZH, Li K, Liu PY, et al. Natural humic-acid-based phototheranostic agent[J]. Adv Healthc Mater, 2018, 7(7): e1701202.
65 Das RK, Panda S, Bhol CS, et al. N-doped carbon quantum dot (NCQD)-deposited carbon capsules for synergistic fluorescence imaging and photothermal therapy of oral cancer[J]. Langmuir, 2019, 35(47): 15320-15329.
66 Mehdizadeh A, Pandesh S, Shakeri-Zadeh A, et al. The effects of folate-conjugated gold nanorods in combination with plasmonic photothermal therapy on mouth epidermal carcinoma cells[J]. Lasers Med Sci, 2014, 29(3): 939-948.
67 Huang XH, El-Sayed IH, Qian W, et al. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods[J]. J Am Chem Soc, 2006, 128(6): 2115-2120.
68 Dickerson EB, Dreaden EC, Huang XH, et al. Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice[J]. Cancer Lett, 2008, 269(1): 57-66.
69 Alzamely KO, Hajizadeh F, Heydari M, et al. Combined inhibition of CD73 and ZEB1 by Arg-Gly-Asp (RGD)-targeted nanoparticles inhibits tumor growth[J]. Colloids Surf B Biointerfaces, 2021, 197: 111421.
70 Ali MRK, Wu Y, Tang Y, et al. Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins[J]. Proc Natl Acad Sci U S A, 2017, 114(28): E5655-E5663.
71 Wang BK, Wang JH, Liu Q, et al. Rose-Bengal-conjugated gold nanorods for in vivo photodynamic and photothermal oral cancer therapies[J]. Biomaterials, 2014, 35(6): 1954-1966.
72 Ren SS, Cheng X, Chen MK, et al. Hypotoxic and rapidly metabolic PEG-PCL-C3-ICG nanoparticles for fluorescence-guided photothermal/photodyna-mic therapy against OSCC[J]. ACS Appl Mater Interfaces, 2017, 9(37): 31509-31518.
73 Chu CK, Tu YC, Hsiao JH, et al. Combination of photothermal and photodynamic inactivation of cancer cells through surface plasmon resonance of a gold nanoring[J]. Nanotechnology, 2016, 27(11): 115102.
74 Zhang L, Jing D, Wang L, et al. Unique photochemo-immuno-nanoplatform against orthotopic xenograft oral cancer and metastatic syngeneic breast cancer[J]. Nano Lett, 2018, 18(11): 7092-7103.
75 Xiong J, Feng JL, Qiu LH, et al. SDF-1-loaded PLGA nanoparticles for the targeted photoacoustic imaging and photothermal therapy of metastatic lymph nodes in tongue squamous cell carcinoma[J]. Int J Pharm, 2019, 554: 93-104.
76 Wang YF, Zhang WS, Sun PF, et al. A novel multimodal NIR-Ⅱ nanoprobe for the detection of metastatic lymph nodes and targeting chemo-photothermal therapy in oral squamous cell carcinoma[J]. Theranostics, 2019, 9(2): 391-404.
77 Neshastehriz A, Tabei, Maleki S, et al. Photothermal therapy using folate conjugated gold nanoparticles enhances the effects of 6MV X-ray on mouth epidermal carcinoma cells[J]. J Photochem Photobiol B, 2017, 172: 52-60.
78 Xue XD, Huang YE, Bo RN, et al. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment[J]. Nat Commun, 2018, 9(1): 3653.
[1] 周金阔,张晋弘,史晓晶,刘广顺,姜磊,刘倩峰. 长链非编码RNA小核仁RNA宿主基因22调控微小RNA-27b-3p对口腔鳞状细胞癌细胞增殖、侵袭和迁移的影响[J]. 国际口腔医学杂志, 2024, 51(1): 52-59.
[2] 李立恒,王蕊,王晓明,张智轶,张璇,安峰,王芹,张凡. 环状RNA hsa_circ_0085576调控微小RNA-498/B细胞特异性莫洛尼鼠白血病病毒整合位点1轴对口腔鳞状细胞癌细胞迁移和侵袭的影响[J]. 国际口腔医学杂志, 2024, 51(1): 60-67.
[3] 吴佳敏,夏斌,杨禾丰,许彪. 癌相关成纤维细胞在口腔鳞状细胞癌微环境中作用的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 711-717.
[4] 柳江龙, 买买提吐逊·吐尔地. 超声造影在口腔鳞状细胞癌颈部转移性淋巴结诊断中的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 514-520.
[5] 盛南宁,王珏,南欣荣. 性别决定基因盒9在口腔鳞状细胞癌作用机制和治疗中的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 314-320.
[6] 李潭,梁新华. 盘状蛋白结构域受体1在调控恶性肿瘤进展和治疗中的作用[J]. 国际口腔医学杂志, 2023, 50(2): 230-236.
[7] 江涵,神应强,陈谦明. 毒蕈碱受体通过Yes相关蛋白信号对口腔鳞状细胞癌生物学行为的实验研究[J]. 国际口腔医学杂志, 2022, 49(2): 138-143.
[8] 蒋宇磊,夏斌,饶南荃,杨禾丰,许彪. 外泌体在口腔鳞状细胞癌恶性进展及诊疗应用的研究[J]. 国际口腔医学杂志, 2021, 48(6): 711-717.
[9] 甘建国,高攀,王晓毅. 循环肿瘤细胞与口腔鳞状细胞癌相关性的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 205-212.
[10] 黄俊文,乔洁,梅子,陈茁,李杨,乔彬. 脂多糖结合蛋白在口腔鳞状细胞癌中的表达及其临床意义[J]. 国际口腔医学杂志, 2021, 48(1): 50-57.
[11] 何宇晴,但红霞,陈谦明. 光动力疗法在口腔黏膜癌变防治中的应用[J]. 国际口腔医学杂志, 2020, 47(6): 669-676.
[12] 郝福,宁毅,孙睿,郑晓旭. 口腔鳞状细胞癌中转化因子2β的表达及潜在的临床意义[J]. 国际口腔医学杂志, 2020, 47(2): 159-165.
[13] 薛伶俐,李雅冬. 经首次根治性手术治疗口腔鳞状细胞癌患者的生存相关影响因素分析[J]. 国际口腔医学杂志, 2020, 47(2): 166-174.
[14] 董云梅,陶艳,周瑜. 口腔黏膜癌变过程中血清生化标志物的研究进展[J]. 国际口腔医学杂志, 2020, 47(1): 43-50.
[15] 陈宏丽,杨敬,尹刚,李皓缘,乔燕. 锌指蛋白32在口腔鳞状细胞癌中的表达意义及对口腔鳞状细胞癌干细胞的影响[J]. 国际口腔医学杂志, 2019, 46(6): 631-639.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .