国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 159-165.doi: 10.7518/gjkq.2020039
Hao Fu1,Ning Yi1,Sun Rui2(),Zheng Xiaoxu3
摘要:
目的 探讨口腔鳞状细胞癌(OSCC)中转化因子2β(Tra2β)的表达及临床意义。方法 利用免疫组化检测64例OSCC中Tra2β蛋白的表达,并分析Tra2β蛋白表达与临床病理参数间的关系。Western blot和实时荧光聚合酶链反应(RT-PCT)检测22例OSCC肿瘤和癌旁组织中Tra2β蛋白和mRNA的表达情况。Kaplan-Meier分析Tra2β蛋白的表达对OSCC患者生存率的影响。Cox多因素生存分析Tra2β蛋白表达对OSCC患者预后的影响。结果 免疫组化检测结果表明Tra2β蛋白在OSCC中表达,并且它的阳性表达与分化程度和临床分期有关。实验结果表明,Tra2β蛋白和mRNA在OSCC中的表达趋势一致,肿瘤组织中Tra2β蛋白和mRNA的表达均高于癌旁组织。Kaplan-Meier分析表明,Tra2β蛋白高表达患者的预后较差。Cox多因素分析表明,Tra2β蛋白是OSCC患者预后评估的一个指标。结论 Tra2β可能为OSCC治疗的一个新的分子靶点。
中图分类号:
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