国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (2): 230-236.doi: 10.7518/gjkq.2023003

• 综述 • 上一篇    下一篇

盘状蛋白结构域受体1在调控恶性肿瘤进展和治疗中的作用

李潭(),梁新华()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔外科门诊 成都 610041
  • 收稿日期:2022-07-19 修回日期:2022-11-10 出版日期:2023-03-01 发布日期:2023-03-14
  • 通讯作者: 梁新华
  • 作者简介:李潭，医师，硕士，Email：18843113788@163.com
  • 基金资助:
    国家自然科学基金(82073000)

Role of discoidin domain receptor 1 in the regulation of malignant tumor progression and therapy

Li Tan(),Liang Xin-hua.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-07-19 Revised:2022-11-10 Online:2023-03-01 Published:2023-03-14
  • Contact: Xin-hua. Liang
  • Supported by:
    National Natural Science Foundation of China(82073000)

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摘要：

盘状蛋白结构域受体1（DDR1）是特殊类型的跨膜受体酪氨酸激酶，在口腔鳞状细胞癌等多种肿瘤中异常表达，并能调控肿瘤进展相关的分子通路。DDR1可参与多种生物学过程，如细胞增殖、分化、迁移、侵袭、休眠和凋亡，还与肿瘤的上皮间充质转化、免疫排斥、代谢重编程和化疗药物耐药密切相关。部分DDR1抑制剂已在临床研究中显示出抗癌功效。本文回顾了DDR1在肿瘤进展中和DDR1抑制剂在肿瘤治疗中的作用，以期为恶性肿瘤的靶向治疗提供新思路。

关键词: 盘状蛋白结构域受体1, 口腔鳞状细胞癌, 恶性肿瘤, 抑制剂, 靶向治疗

Abstract:

Discoidin domain receptor 1 (DDR1) is a special type of transmembrane receptor tyrosine kinase that is aberrantly expressed in various tumors, including oral squamous cell carcinoma, and can regulate molecular pathways related to tumor progression. DDR1 is involved in a variety of biological processes, such as cell proliferation, differentiation, migration, invasion, dormancy, and apoptosis, and is also closely related to tumor epithelial-mesenchymal transition, immune rejection, metabolic reprogramming, and chemotherapeutic drug resistance. Some DDR1 inhibitors have shown anticancer efficacy in clinical studies. This article reviews the roles of DDR1 in tumor progression and DDR1 inhibitors in tumor therapy to provide new ideas for the targeted therapy of malignant tumors.

Key words: discoidin domain receptor 1, oral squamous cell carcinoma, malignant tumor, inhibitor, targeted therapy

中图分类号: 

  • Q 257

图 1

DDR1的结构和亚型DDR1的结构和子类型。DDR1a、b和c是激酶活性的，而DDR1d和e是激酶域缺陷的。AA：amino acid，氨基酸；DS：discoidin domain，盘状结构域；DS-like：discoidin-like domain，盘状蛋白样结构域；EJXM：extracellular juxtamembrane region，细胞外近膜区；IJXM：intracellular juxtamembrane region，细胞内近膜区；KD：kinase domain，激酶结构域；TM：transmembrane segment，跨膜片段；C-tail：尾部。"

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