国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (6): 711-717.doi: 10.7518/gjkq.2023110

• 综述 • 上一篇    下一篇

癌相关成纤维细胞在口腔鳞状细胞癌微环境中作用的研究进展

吴佳敏(),夏斌,杨禾丰,许彪()   

  1. 昆明医科大学附属口腔医院口腔颌面外科 昆明 650500
  • 收稿日期:2023-03-25 修回日期:2023-07-26 出版日期:2023-11-01 发布日期:2023-10-24
  • 通讯作者: 许彪
  • 作者简介:吴佳敏，硕士，Email：694467788@qq.com
  • 基金资助:
    云南省口腔医学重点实验室项目(202005AG070041);云南省卫生健康委员会内设机构项目(2018NS0210)

Research progress on cancer-associated fibroblasts in the tumor microenvironment of oral squamous cell carcinoma

Wu Jiamin(),Xia Bin,Yang Hefeng,Xu Biao.()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650500, China
  • Received:2023-03-25 Revised:2023-07-26 Online:2023-11-01 Published:2023-10-24
  • Contact: Biao. Xu
  • Supported by:
    Yunnan Provincial Key Laboratory of Stomatology(202005AG070041);Yunnan Provincial Health Commission Internal Institutions Project(2018NS0210)

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摘要：

癌相关成纤维细胞是肿瘤微环境中数目最为丰富的基质细胞。越来越多的研究发现癌相关成纤维细胞对肿瘤的发生发展发挥着巨大作用。癌相关成纤维细胞不仅能够重塑细胞外基质，调节肿瘤代谢，参与免疫调节，还能促进肿瘤的生长、血管生成、迁移和侵袭等。因此，破坏癌相关成纤维细胞与周围环境的交互可能提供新的治疗思路。本文将对癌相关成纤维细胞在口腔鳞状细胞癌中的研究进展进行综述。

关键词: 癌相关成纤维细胞, 口腔鳞状细胞癌, 肿瘤微环境

Abstract:

Cancer-associated fibroblasts are the most abundant stromal cells in the tumor microenvironment. An increasing number of studies have found that cancer-associated fibroblasts play a remarkable role in the development of tumors. Cancer-associated fibroblasts remodel the extracellular matrix, regulate tumor metabolism, and participate in immune regulation, and promote tumor growth, angiogenesis, migration, and invasion. Therefore, disrupting the interaction between cancer-associated fibroblasts and the surrounding environment may provide us with new therapeutic ideas. In this paper, we will review the research progress on cancer-associated fibroblasts in oral squamous carcinoma.

Key words: cancer-associated fibroblast, oral squamous cell carcinoma, tumor microenvironment

中图分类号: 

  • R 739.81
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