国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 48-54.doi: 10.7518/gjkq.2019.01.009
Zhengmou Dong1,Rui Liu2,Luchuan Liu2(),Xiujie Wen2
摘要:
牙周病是一种慢性感染性疾病,可破坏牙周组织,甚至导致牙齿丧失。随着对牙周病发病机制认识的不断深入,治疗重点已从药物、机械治疗阻止疾病发展转变为促进牙周组织的再生和重建。牙周组织工程已成为牙周病治疗的新方向。牙周组织再生治疗的三大要素为种子细胞、生长因子和支架材料,种子细胞是牙周组织再生治疗最关键的部分之一。本文就牙周组织再生治疗的种子细胞的研究进展进行综述。
中图分类号:
[1] |
Khanuja PK, Narula SC, Rajput R , et al. Association of periodontal disease with glycemic control in pa-tients with type 2 diabetes in Indian population[J]. Front Med, 2017,11(1):110-119.
doi: 10.1007/s11684-016-0484-5 pmid: 28050765 |
[2] |
Fernandes G, Yang SY . Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering[J]. Bone Res, 2016,4:16036.
doi: 10.1038/boneres.2016.36 pmid: 28018706 |
[3] | 李玮, 孟雪梅 . 牙周组织工程种子细胞及其体内移植方法的研究进展[J]. 中国修复重建外科杂志, 2010,24(10):1249-1252. |
Li W, Meng XM . Research progress of cells and cell-transplantation methods for periodontal tissue engi-neering[J]. Chin J Repara Reconstr Surg, 2010,24(10):1249-1252. | |
[4] |
Ogawa K, Miyaji H, Kato A , et al. Periodontal tissue engineering by nano beta-tricalcium phosphate scaf-fold and fibroblast growth factor-2 in one-wall infra-bony defects of dogs[J]. J Periodont Res, 2016,51(6):758-767.
doi: 10.1111/jre.12352 pmid: 27870141 |
[5] |
Ivanovski S, Vaquette C, Gronthos S , et al. Multiphasic scaffolds for periodontal tissue engineering[J]. J Dent Res, 2014,93(12):1212-1221.
doi: 10.1177/0022034514544301 pmid: 25139362 |
[6] |
Monsarrat P, Vergnes JN, Nabet C , et al. Concise review: mesenchymal stromal cells used for perio-dontal regeneration: a systematic review[J]. Stem Cells Transl Med, 2014,3(6):768-774.
doi: 10.5966/sctm.2013-0183 pmid: 4039455 |
[7] |
Han J, Menicanin D, Marino V , et al. Assessment of the regenerative potential of allogeneic periodontal ligament stem cells in a rodent periodontal defect model[J]. J Periodont Res, 2014,49(3):333-345.
doi: 10.1111/jre.12111 pmid: 23841948 |
[8] |
Chen FM, Gao LN, Tian BM , et al. Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial[J]. Stem Cell Res Ther, 2016,7:33.
doi: 10.1186/s13287-016-0288-1 pmid: 4761216 |
[9] |
Kabir R, Gupta M, Aggarwal A , et al. Imperative role of dental pulp stem cells in regenerative thera-pies: a systematic review[J]. Niger J Surg, 2014,20(1):1-8.
doi: 10.4103/1117-6806.127092 pmid: 3953626 |
[10] |
Ashri NY, Ajlan SA, Aldahmash AM . Dental pulp stem cells. Biology and use for periodontal tissue engineering[J]. Saudi Med J, 2015,36(12):1391-1399.
doi: 10.15537/smj.2015.12.12750 pmid: 26620980 |
[11] |
Miura M, Gronthos S, Zhao M , et al. SHED: stem cells from human exfoliated teeh[J]. Proc Natl Acad Sci USA, 2003,100(10):5807-5812.
doi: 10.1073/pnas.0937635100 |
[12] |
Ishiy FA, Fanganiello RD, Griesi-Oliveira K , et al. Improvement of in vitro osteogenic potential through differentiation of induced pluripotent stem cells from human exfoliated dental tissue towards mesenchymal-like stem cells[J]. Stem Cells Int, 2015,2015:249098.
doi: 10.1155/2015/249098 pmid: 25802529 |
[13] |
Ma L, Makino Y, Yamaza H , et al. Cryopreserved dental pulp tissues of exfoliated deciduous teeth is a feasible stem cell resource for regenerative medicine[J]. PLoS One, 2012,7(12):e51777.
doi: 10.1371/journal.pone.0051777 pmid: 23251621 |
[14] |
Lucaciu O, Soritau O, Gheban D , et al. Dental follicle stem cells in bone regeneration on titanium implants[J]. BMC Biotechnol, 2015,15:114.
doi: 10.1186/s12896-015-0229-6 pmid: 4697321 |
[15] |
Sowmya S, Chennazhi KP, Arzate H , et al. Perio-dontal specific differentiation of dental follicle stem cells into osteoblast, fibroblast, and cementoblast[J]. Tissue Eng Part C Methods, 2015,21(10):1044-1058.
doi: 10.1089/ten.TEC.2014.0603 pmid: 25962715 |
[16] |
Huang G, Sonoyama W, Liu Y , et al. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering[J]. J Endod, 2008,34(6):645-651.
doi: 10.1016/j.joen.2008.03.001 pmid: 18498881 |
[17] |
Diao S, Yang DM, Dong R , et al. Enriched trime-thylation of lysine 4 of histone H3 of WDR63 enhan-ced osteogenic differentiation potentials of stem cells from apical papilla[J]. J Endod, 2015,41(2):205-211.
doi: 10.1016/j.joen.2014.09.027 pmid: 25498833 |
[18] |
Zhang QB, Cao W, Liu YR , et al. Effects of Sirtuin 1 on the proliferation and osteoblastic differentiation of periodontal ligament stem cells and stem cells from apical papilla[J]. Genet Mol Res, 2016,15(1). doi: 10.4238/gmr.15015234.
doi: 10.4238/gmr.15015234 pmid: 27050994 |
[19] |
Nakajima R, Ono M, Hara ES , et al. Mesenchymal stem/progenitor cell isolation from tooth extraction sockets[J]. J Dent Res, 2014,93(11):1133-1140.
doi: 10.1177/0022034514549377 pmid: 25170030 |
[20] |
Luo J, Xu J, Cai J , et al. The in vitro and in vivo osteogenic capability of the extraction socket-derived early healing tissue[J]. J Periodontol, 2016,87(9):1057-1066.
doi: 10.1902/jop.2016.160078 pmid: 27108477 |
[21] |
Zhou LL, Liu HW, Wen XX , et al. Involvement of bone marrow stem cells in periodontal wound healing[J]. Chin J Dent Res, 2014,17(2):105-110.
pmid: 25531018 |
[22] |
李艳芬, 闫福华, 钟泉 , 等. 人骨形成蛋白-7基因转染犬骨髓基质细胞促进牙周组织再生的实验研究[J]. 中华医学杂志, 2010,90(20):1427-1430.
doi: 10.3760/cma.j.issn.0376-2491.2010.20.017 |
Li YF, Yan FH, Zhong Q , et al. Effect of hBMP-7 gene modified bone marrow stromal cells on perio-dontal tissue regeneration[J]. Natl Med J Chin, 2010,90(20):1427-1430.
doi: 10.3760/cma.j.issn.0376-2491.2010.20.017 |
|
[23] |
Tobita M, Uysal AC, Ogawa R , et al. Periodontal tissue regeneration with adipose-derived stem cells[J]. Tissue Eng Part A, 2008,14(6):945-953.
doi: 10.1089/ten.tea.2007.0048 pmid: 18558814 |
[24] |
Akita D, Morokuma M, Saito Y , et al. Periodontal tissue regeneration by transplantation of rat adipose-derived stromal cells in combination with PLGA-based solid scaffolds[J]. Biomed Res, 2014,35(2):91-103.
doi: 10.2220/biomedres.35.91 pmid: 24759177 |
[25] |
Yang J, Hsu CW, Liao S , et al. Transplantation of embryonic stem cells improves the regeneration of periodontal furcation defects in a porcine model[J]. J Clin Periodontol, 2013,40(4):364-371.
doi: 10.1111/jcpe.12069 pmid: 23431981 |
[26] |
Duan XJ, Tu QS, Zhang J , et al. Application of in-duced pluripotent stem (iPS) cells in periodontal tissue regeneration[J]. J Cell Physiol, 2011,226(1):150-157.
doi: 10.1002/jcp.22316 pmid: 4137963 |
[27] |
Dominici M, Le Blanc K, Mueller I , et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006,8(4):315-317.
doi: 10.1080/14653240600855905 pmid: 16923606 |
[28] |
Hynes K, Menicanin D, Gronthos S , et al. Clinical utility of stem cells for periodontal regeneration[J]. Periodontol 2000, 2012,59(1):203-227.
doi: 10.1111/j.1600-0757.2012.00443.x pmid: 22507067 |
[29] |
Cao Y, Liu ZH, Xie YL , et al. Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal re-generation in swine[J]. Stem Cell Res Ther, 2015,6:249.
doi: 10.1186/s13287-015-0244-5 pmid: 4681125 |
[30] |
尚姝环, 张玉峰, 施斌 , 等. 新型重组人血小板衍化生长因子B腺病毒载体的构建与转染牙周干细胞的研究[J]. 中华口腔医学杂志, 2008,43(10):584-588.
doi: 10.3321/j.issn:1002-0098.2008.10.003 |
Shang SH, Zhang YF, Shi B , et al. Construction and identification of recombinant human platelet-derived growth factor-B adenoviral vector and transfection into periodontal ligament stem cells[J]. Chin J Sto-matol, 2008,43(10):584-588.
doi: 10.3321/j.issn:1002-0098.2008.10.003 |
|
[31] |
Halme DG, Kessler DA . FDA regulation of stem-cell-based therapies[J]. N Engl J Med, 2006,355(16):1730-1735.
doi: 10.1056/NEJMhpr063086 |
[32] |
Li HX, Yan FH, Lei L , et al. Application of autolo-gous cryopreserved bone marrow mesenchymal stem cells for periodontal regeneration in dogs[J]. Cells Tissues Organs (Print), 2009,190(2):94-101.
doi: 10.1159/000166547 pmid: 18957835 |
[33] |
Zahra SA, Muzavir SR, Ashraf S , et al. Stem cell research in pakistan; past, present and future[J]. Int J Stem Cells, 2015,8(1):1-8.
doi: 10.15283/ijsc.2015.8.1.1 pmid: 4445703 |
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