国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (2): 165-172.doi: 10.7518/gjkq.2021040
摘要:
目的 采用Meta分析探讨牙周病和心肌梗死(MI)发生风险的相关性。方法 采用计算机检索PubMed、Embase、Cochrane library、CNKI、万方、维普和中国生物医学文献数据库中关于牙周病与MI相关性的队列研究,检索时限均为建库至2020年8月31日。由2位研究人员独立筛选文献并提取资料,采用纽卡斯尔-渥太华量表(NOS)评价所纳入研究的偏移风险,采用Review Manager 5.3软件进行Meta分析,计算纳入文献的合并危险比(RR)及95%置信区间(CI),并进行亚组分析和敏感性分析以确定异质性来源。结果 共纳入8个队列研究,涉及的总研究人数为207 922例。Meta分析结果显示:牙周病患者发生MI风险增加(RR=1.21,95%CI为1.05~1.40,P=0.008);敏感性分析表明:Meta分析结果的稳健性良好;亚组分析结果显示:性别(女性:RR=1.39,95%CI为1.17~1.65,P=0.000 2;男性:RR=1.05,95%CI为0.89~1.24,P=0.580)、测量指标、效应值、研究质量对结果有明显影响。结论 牙周病与MI发生有相关性,在女性人群中尤其明显。
中图分类号:
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