国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (4): 425-432.doi: 10.7518/gjkq.2018.04.010
宋洪宁1, 王旭霞2, 张君2
Song Hongning1, Wang Xuxia2, Zhang Jun2
摘要: 长链非编码RNA(lncRNA)是一类长度大于200 nt的不具备编码蛋白质功能的RNA,近年来才获得较多的关注,发现其在生命过程中发挥关键作用。越来越多的研究表明,lncRNA在细胞生理过程中扮演了重要的角色,包括细胞增殖、分化、凋亡、迁移、入侵和染色质重塑。更重要的是,lncRNA在肿瘤生物学和预后方面的作用越来越被认可,多项研究表明,lncRNA对肿瘤的生长和转移起重要作用,与多种肿瘤的预后不良相关,lncRNA可能是潜在的肿瘤标志物和治疗靶标。lncRNA被发现存在于多个肿瘤表达缺失,然而其对肿瘤发生、发展和转移的分子机制仍不完全明确。本文强调了lncRNA在肿瘤发病机制中的最新发现,总结概述了lncRNA在不同肿瘤中的表达和作用,发现lncRNA已经成为一类新的有前途的肿瘤标记物,许多独立研究证实其作为恶性肿瘤诊断、预后、预测和监测治疗反应工具的可行性。对lncRNA在肿瘤发生、发展中的作用的研究虽然仍处于初级阶段,但毫无疑问,了解lncRNA的活动必将改善肿瘤患者的治疗。
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