国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (4): 420-424.doi: 10.7518/gjkq.2018.04.009

• 综述 • 上一篇    下一篇

非编码RNA在舌鳞状细胞癌中的研究进展

王丽萍, 查骏, 葛林虎   

  1. 广州医科大学附属口腔医院种植科 广州口腔疾病研究所口腔医学重点实验室 广州 510140
  • 收稿日期:2017-11-01 修回日期:2018-02-20 出版日期:2018-07-02 发布日期:2018-07-02
  • 通讯作者: 葛林虎,教授,博士,Email：gelinhu@yeah.net
  • 作者简介:王丽萍,主任医师,硕士,Email：wangliplj@126.com
  • 基金资助:
    广东省科学技术厅项目（2013B021800186）

Research progress on non-coding RNAs in tongue squamous cell carcinoma

Wang Liping, Zha Jun, Ge Linhu.   

  1. Dept. of Implantology, Stomatology Hospital of Guangzhou Medical University, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Guangzhou 510140, China
  • Received:2017-11-01 Revised:2018-02-20 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Guangdong Provincial Science and Technology Agency (2013B021800186).

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摘要： 随着整个基因组学和转录组学测序技术的发展,非编码RNA（ncRNA）越来越受到关注。大量研究发现,ncRNA可以通过对染色体重构、转录和转录后翻译等生物学进程来调节基因的表达,并且这些异常表达的ncRNA与人类多种疾病（例如肿瘤）的发生、发展联系十分紧密。ncRNA逐渐成为肿瘤研究中诊断和预后的新型生物学标记和靶向治疗策略。ncRNA在人的舌鳞状细胞癌中也发挥着重要的作用,本文对ncRNA在舌鳞状细胞癌中的研究进展进行综述。

关键词: 非编码RNA, 舌鳞状细胞癌, 生物标记, 靶向治疗

Abstract: As the development of genomics and transcriptomics, non-coding RNAs (ncRNAs) have been paid much attention. Previous studies have suggested that ncRNAs could regulate gene expression through several biological processes such as chromosome remodeling, transcription, and posttranscription translation. Abnormal versions of ncRNAs are closely related to several human diseases such as the generation and development of tumors. Therefore, ncRNAs may become novel biomarkers in the diagnosis, prognosis and target therapies of tumor research. As the essential role of ncRNAs playing in tongue squamous cell carcinoma (TSCC), the latest domestic and foreign literatures in TSCC progression were reviewed in this article.

Key words: non-coding RNA, tongue squamous cell carcinoma, biomarker, target therapy

中图分类号: 

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