国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (4): 431-438.doi: 10.7518/gjkq.2020038
Kong Lixin,Ren Biao,Cheng Lei()
摘要:
口咽癌是全球第6大最常见的恶性肿瘤,5年生存率低于60%,严重影响着人类的健康和生活质量。口腔肿瘤中环氧合酶2(COX-2)/前列腺素E2(PGE2)显著高表达,表明该通路与口腔肿瘤密切相关,是口腔肿瘤重要的调控通路。研究表明COX-2/PGE2通路可通过上调表皮生长因子受体促进肿瘤生长、上调内皮生长因子调节血管生成、上调Bcl-2调节凋亡等不同方式调节口腔肿瘤的发生、发展。本文对该通路在口腔肿瘤中的研究进展进行综述。
中图分类号:
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