国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (1): 108-113.doi: 10.7518/gjkq.2017.01.022
刘润恒,刘于冬,陈卓凡
Liu Runheng, Liu Yudong, Chen Zhuofan.
摘要: 在口腔种植治疗过程中常常会遇到骨量不足的问题,植入骨替代材料是目前临床上最主要的重建骨缺损方法之一,因此骨替代材料的成骨性能及其分子机制成为了研究热点。微小RNA(miRNA)是一种短链非编码RNA,通过转录后调控细胞分化、增殖、程序性死亡等病理生理过程。miRNA可影响成骨相关因子的表达和激活成骨相关信号转导通路中的信号转导,从而对骨组织动态改建过程进行调控。本文就miRNA与成骨细胞特异性转录因子、核心结合因子-α1基因、Smad基因、转化生长因子-β诱导因子,与骨形态发生蛋白信号转导通路、无翅型小鼠乳房肿瘤病毒整合位点家族信号转导通路、促丝裂原激活蛋白激酶信号转导通路、成脂信号转导通路以及miRNA与口腔相关材料和miRNA在骨缺损修复中的应用研究进展作一综述。
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[1] Sriram M, Sainitya R, Kalyanaraman V, et al. Bio-materials mediated microRNA delivery for bone tissue engineering[J]. Int J Biol Macromol, 2015, 74: 404-412. [2] Dong S, Yang B, Guo H, et al. MicroRNAs regulate osteogenesis and chondrogenesis[J]. Biochem Bio-phys Res Commun, 2012, 418(4):587-591. [3] Hutvágner G, McLachlan J, Pasquinelli AE, et al. A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA[J]. Science, 2001, 293(5531):834-838. [4] Bartel DP. MicroRNAs: genomics, biogenesis, me-chanism, and function[J]. Cell, 2004, 116(2):281- 297. [5] Hassan MQ, Tye CE, Stein GS, et al. Non-coding RNAs: epigenetic regulators of bone development and homeostasis[J]. Bone, 2015, 81:746-756. [6] Nakashima K, Zhou X, Kunkel G, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone for-mation[J]. Cell, 2002, 108(1):17-29. [7] Baglìo SR, Devescovi V, Granchi D, et al. Micro-RNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic dif-ferentiation reveals osterix regulation by miR-31[J]. Gene, 2013, 527(1):321-331. [8] Shi K, Lu J, Zhao Y, et al. MicroRNA-214 suppre-sses osteogenic differentiation of C2C12 myoblast cells by targeting osterix[J]. Bone, 2013, 55(2):487- 494. [9] Li E, Zhang J, Yuan T, et al. MiR-143 suppresses osteogenic differentiation by targeting osterix[J]. Mol Cell Biochem, 2014, 390(1/2):69-74. [10] Liu H, Sun Q, Wan C, et al. MicroRNA-338-3p regulates osteogenic differentiation of mouse bone marrow stromal stem cells by targeting Runx2 and Fgfr2[J]. J Cell Physiol, 2014, 229(10):1494-1502. [11] Zuo B, Zhu J, Li J, et al. microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2[J]. J Bone Miner Res, 2015, 30(2):330-345. [12] Panchision DM, Pickel JM, Studer L, et al. Sequen-tial actions of BMP receptors control neural pre-cursor cell production and fate[J]. Genes Dev, 2001, 15(16):2094-2110. [13] Kato RB, Roy B, de Oliveira FS, et al. Nanotopo-graphy directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit[J]. J Cell Physiol, 2014, 229(11): 1690-1696. [14] Wu T, Zhou H, Hong Y, et al. miR-30 family mem-bers negatively regulate osteoblast differentiation[J]. J Biol Chem, 2012, 287(10):7503-7511. [15] Krzeszinski JY, Wei W, Huynh H, et al. miR-34a blocks osteoporosis and bone metastasis by inhibi-ting osteoclastogenesis and Tgif2[J]. Nature, 2014, 512(7515):431-435. [16] Moorthi A, Vimalraj S, Avani C, et al. Expression of microRNA-30c and its target genes in human osteo-blastic cells by nano-bioglass ceramic-treatment[J]. Int J Biol Macromol, 2013, 56:181-185. [17] Kureel J, Dixit M, Tyagi AM, et al. miR-542-3p suppresses osteoblast cell proliferation and differen-tiation, targets BMP-7 signaling and inhibits bone formation[J]. Cell Death Dis, 2014, 5:e1050. [18] Hupkes M, Sotoca AM, Hendriks JM, et al. Micro-RNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells[J]. BMC Mol Biol, 2014, 15:1. [19] Liao YH, Chang YH, Sung LY, et al. Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b[J]. Bioma-terials, 2014, 35(18):4901-4910. [20] Kieslinger M, Folberth S, Dobreva G, et al. EBF2 regulates osteoblast-dependent differentiation of osteoclasts[J]. Dev Cell, 2005, 9(6):757-767. [21] Wang T, Xu Z. miR-27 promotes osteoblast diffe-rentiation by modulating Wnt signaling[J]. Biochem Biophys Res Commun, 2010, 402(2):186-189. [22] Meng YB, Li X, Li ZY, et al. microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K/β-catenin pathway[J]. J Orthop Res, 2015, 33(7):957-964. [23] Wang Q, Cai J, Cai XH, et al. miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway[J]. PLoS ONE, 2013, 8(9):e72266. [24] Vimalraj S, Selvamurugan N. MicroRNAs expre-ssion and their regulatory networks during mesen-chymal stem cells differentiation toward osteoblasts [J]. Int J Biol Macromol, 2014, 66:194-202. [25] Zhang Z, Wang J, Lü X. An integrated study of natural hydroxyapatite-induced osteogenic dif-ferentiation of mesenchymal stem cells using tran-scriptomics, proteomics and microRNA analyses[J]. Biomed Mater, 2014, 9(4):045005. [26] Mei Y, Bian C, Li J, et al. miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation[J]. J Cell Biochem, 2013, 114(6): 1374-1384. [27] Elabd C, Basillais A, Beaupied H, et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis[J]. Stem Cells, 2008, 26(9):2399-2407. [28] Li W, Yuan Y, Huang L, et al. Metformin alters the expression profiles of microRNAs in human pan-creatic cancer cells[J]. Diabetes Res Clin Pract, 2012, 96(2):187-195. [29] Sun J, Wang Y, Li Y, et al. Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential[J]. J Transl Med, 2014, 12:168. [30] Li CJ, Cheng P, Liang MK, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation[J]. J Clin Invest, 2015, 125 (4):1509-1522. [31] Palmieri A, Pezzetti F, Brunelli G, et al. Anorganic bovine bone(Bio-Oss) regulates miRNA of osteo-blast-like cells[J]. Int J Periodontics Restorative Dent, 2010, 30(1):83-87. [32] Palmieri A, Pezzetti F, Avantaggiato A, et al. Ti-tanium acts on osteoblast translational process[J]. J Oral Implantol, 2008, 34(4):190-195. [33] Palmieri A, Pezzetti F, Brunelli G, et al. Zirconium oxide regulates RNA interfering of osteoblast-like cells[J]. J Mater Sci Mater Med, 2008, 19(6):2471- 2476. [34] Chakravorty N, Ivanovski S, Prasadam I, et al. The microRNA expression signature on modified ti-tanium implant surfaces influences genetic me-chanisms leading to osteogenic differentiation[J]. Acta Biomater, 2012, 8(9):3516-3523. [35] Wang Z, Zhang D, Hu Z, et al. MicroRNA-26a-modified adipose-derived stem cells incorporated with a porous hydroxyapatite scaffold improve the repair of bone defects[J]. Mol Med Rep, 2015, 12(3): 3345-3350. [36] Deng Y, Zhou H, Gu P, et al. Repair of canine me-dial orbital bone defects with miR-31-modified bone marrow mesenchymal stem cells[J]. Invest Ophthal-mol Vis Sci, 2014, 55(9):6016-6023. [37] Li KC, Chang YH, Yeh CL, et al. Healing of osteo-porotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges[J]. Biomaterials, 2016, 74:155-166. (本文采编 王晴) |
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