Int J Stomatol ›› 2022, Vol. 49 ›› Issue (5): 586-592.doi: 10.7518/gjkq.2022070

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Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis

Zhou Jianpeng(),Xie Xudong,Zhao Lei,Wang Jun.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-11-18 Revised:2022-04-25 Online:2022-09-01 Published:2022-09-16
  • Contact: Jun. Wang E-mail:jpzhou96@163.com;junwang@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82071127);Sichuan Province Science and Technology Support Program(2019YJ0097)

Abstract:

Periodontitis is a chronic infectious disease characterized by the destruction of periodontal supporting tissues, and plaque biofilms have been identified as the initial factors. Host immune response triggered by the colonization of plaque biofilms plays a critical role in the occurrence and development of periodontitis. T-helper 17 cells (Th17) and their main pro-inflammatory cytokine interleukin-17 (IL-17) are indispensable in periodontitis. Previous studies have de-monstrated increased infiltration of Th17 cell and a high level of IL-17 in periodontal lesions, and the increased levels are related to the severity of periodontitis. This review article aims to summarize progress in research on the roles and mechanisms of Th17 cells and IL-17 in periodontitis.

Key words: T-helper 17 cell, cytokine, interleukin-17, periodontitis, immune response

CLC Number: 

  • R 781.4+2

TrendMD: 

Fig 1

The role of Th17 cells and IL-17 in the destruction of periodontal supporting tissue"

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