国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (2): 199-203.doi: 10.7518/gjkq.2018.02.013

• 综述 • 上一篇    下一篇

药物性牙龈增生与细胞增殖和凋亡相关性的研究进展

詹烨明, 张明珠   

  1. 昆明医科大学附属口腔医院牙周科 昆明 650000
  • 收稿日期:2017-09-25 修回日期:2017-12-20 出版日期:2018-03-01 发布日期:2018-03-01
  • 通讯作者: 张明珠,副教授,博士,Email：mingzhu_2070@qq.com
  • 作者简介:詹烨明,硕士,Email：258911196@qq.com
  • 基金资助:
    云南省科学技术厅-昆明医科大学应用基础研究联合项目（2- 014FZ039）

Research progress on the relevance between drug-induced gingival overgrowth and cell proliferation and apoptosis

Zhan Yeming, Zhang Mingzhu   

  1. Dept. of Periodontics, Stomatological Hospital, Kunming Medical University, Kunming 650000, China
  • Received:2017-09-25 Revised:2017-12-20 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by Joint Project of Application Fundamental Research, Science and Technology Department, Yunnan Province and Kunming Medical University (2014FZ039).

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摘要： 药物性牙龈增生是指长期服用某些药物（如钙通道阻滞剂、抗癫痫药物和免疫抑制剂）为主要因素而诱发的牙龈体积增大,其发病机制尚未完全明确。近年来研究发现,牙龈增生与细胞的增殖和凋亡有密切关系,本文就药物性牙龈增生与细胞增殖和凋亡的相关性研究进展进行综述。

关键词: 药物性牙龈增生, 细胞增殖, 凋亡, 炎症

Abstract: Patients who received a long-term drug therapy, including calcium channel blockers, antiepileptic and immunosuppressive drugs, often suffered from drug-induced gingival overgrowth (DIGO). However, the pathogenesis of DIGO remains unclear to date. A number of research found that DIGO is relevant to apoptosis and cell proliferation. Research progress on the relevance between drug-induced gingival overgrowth and the apoptosis and cell proliferation is summarised in this paper.

Key words: drug-induced gingival overgrowth, cell proliferation, apoptosis, inflammation

中图分类号: 

  • R781.4+1
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