国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (4): 425-432.doi: 10.7518/gjkq.2018.04.010

• 综述 • 上一篇    下一篇

长链非编码RNA的研究进展及其与口腔肿瘤的关系

宋洪宁1, 王旭霞2, 张君2   

  1. 1.泰山医学院附属医院口腔颌面外科 泰安 271000;
    2.山东大学口腔医学院口腔颌面外科学教研室 济南 250012
  • 收稿日期:2017-08-13 修回日期:2018-03-27 出版日期:2018-07-02 发布日期:2018-07-02
  • 通讯作者: 宋洪宁,主治医师,硕士,Email:13665387902@163.com
  • 作者简介:宋洪宁,主治医师,硕士,Email:13665387902@163.com
  • 基金资助:
    山东省科学技术发展项目(2010GSF10239); 山东省科学技术专项计划项目(2012G0021852)

Long non-coding RNA and its relationship with oral cancer

Song Hongning1, Wang Xuxia2, Zhang Jun2   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Taishan Medical University, Taian 271000, China;
    2. Dept. of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan 250012, China
  • Received:2017-08-13 Revised:2018-03-27 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Science and Technology Development Funds of Shandong Province (2010GSF10239) and Science and Technology Development Special Funds of Shandong Province (2012G0021852).

摘要: 长链非编码RNA(lncRNA)是一类长度大于200 nt的不具备编码蛋白质功能的RNA,近年来才获得较多的关注,发现其在生命过程中发挥关键作用。越来越多的研究表明,lncRNA在细胞生理过程中扮演了重要的角色,包括细胞增殖、分化、凋亡、迁移、入侵和染色质重塑。更重要的是,lncRNA在肿瘤生物学和预后方面的作用越来越被认可,多项研究表明,lncRNA对肿瘤的生长和转移起重要作用,与多种肿瘤的预后不良相关,lncRNA可能是潜在的肿瘤标志物和治疗靶标。lncRNA被发现存在于多个肿瘤表达缺失,然而其对肿瘤发生、发展和转移的分子机制仍不完全明确。本文强调了lncRNA在肿瘤发病机制中的最新发现,总结概述了lncRNA在不同肿瘤中的表达和作用,发现lncRNA已经成为一类新的有前途的肿瘤标记物,许多独立研究证实其作为恶性肿瘤诊断、预后、预测和监测治疗反应工具的可行性。对lncRNA在肿瘤发生、发展中的作用的研究虽然仍处于初级阶段,但毫无疑问,了解lncRNA的活动必将改善肿瘤患者的治疗。

关键词: 长链非编码RNA, 肿瘤, 肿瘤标志物

Abstract: Long non-coding RNA (lncRNA) is a family of non-protein-coding RNAs with length of more than 200 nucleotides. These lncRNAs have gained considerable attention and recently emerged as main participants in biological processes. An increasing number of studies showed that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, migration, invasion and chromatin remodelling. Importantly, lncRNAs are increasingly recognised in cancer biology and prognosis. Multiple studies also indicated that lncRNAs play important roles in tumour growth and metastasis and poor prognosis in multiple tumour types. These RNAs may also act as a potential biomarker and therapeutic target for human cancers. Furthermore, lncRNA deregulation is observed in multiple tumours. However, the molecular mechanism of lncRNAs in cancer initiation, progression and metastasis remains poorly understood. In this review, we highlight the recent findings on lncRNAs in cancer pathogenesis and summarise an overview of current knowledge concerning the expression and role of lncRNA in various cancers. Additionally, lncRNAs emerged as a new class of promising cancer biomarkers. Independent studies demonstrated the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and in the prediction and possible monitoring treatment response. The role of lncRNAs in cancers is an emerging field of study. Although our understanding about the role of lncRNAs in the onset and progression of cancers is still in its infancy, further understanding the activities of lncRNAs will secure improved treatment options for cancer patients.

Key words: long non-coding RNA, cancer, cancer biomarker

中图分类号: 

  • Q52
[1] Djebali S, Davis CA, Merkel A, et al.Landscape of transcription in human cells[J]. Nature, 2012, 489(7414): 101-108.
[2] Liu J, Cheng G, Yang H, et al.Reciprocal regulation of long noncoding RNAs THBS4-003 and THBS4 control migration and invasion in prostate cancer cell lines[J]. Mol Med Rep, 2016, 14(2): 1451-1458.
[3] Okazaki Y, Furuno M, Kasukawa T, et al.Analysis of the mouse transcriptome based on functional an-notation of 60,770 full-length cDNAs[J]. Nature, 2002, 420(6915): 563-573.
[4] Al-Tassan NA, Whiffin N, Hosking FJ, et al.A new GWAS and meta-analysis with 1 000 genomes im-putation identifies novel risk variants for colorectal cancer[J]. Sci Rep, 2015, 5: 10442.
[5] Maass PG, Luft FC, Bähring S.Long non-coding RNA in health and disease[J]. J Mol Med, 2014, 92(4): 337-346.
[6] St laurent G, Wahlestedt C, Kapranov P. The land-scape of long noncoding RNA classification[J]. Trends Genet, 2015, 31(5): 239-251.
[7] Kan JY, Wu DC, Yu FJ, et al.Chemokine (C-C motif) ligand 5 is involved in tumorassociated den-dritic cell-mediated colon cancer progression through non-coding RNA MALAT-1[J]. J Cell Physiol, 2015, 230(8): 1883-1894.
[8] Schaukowitch K, Kim TK.Emerging epigenetic mechanisms of long non-coding RNAs[J]. Neuro-science, 2014, 264: 25-38.
[9] Maass PG, Luft FC, Bähring S.Long non-coding RNA in health and disease[J]. J Mol Med, 2014, 92(4): 337-346.
[10] Zhao XY, Li S, Wang GX, et al.A long noncoding RNA transcriptional regulatory circuit drives thermo-genicadipocyte differentiation[J]. Mol Cell, 2014, 55(3): 372-382.
[11] Monnier P, Martinet C, Pontis J, et al.H19 lncRNA controls gene expression of the imprinted gene net-work by recruiting MBD1[J]. Proc Natl Acad Sci USA, 2013, 110(51): 20693-20698.
[12] Charlton J, Williams RD, Sebire NJ, et al.Compara-tive methylome analysis identifies new tumour sub-types and biomarkers for transformation of nephro-genic rests into Wilms tumour[J]. Genome Med, 2015, 7(1): 11.
[13] Lv J, Ma L, Chen XL, et al.Downregulation of lnc-RNA H19 and MiR-675 promotes migration and invasion of human hepatocellular carcinoma cells through AKT/GSK-3β/Cdc25A signaling pathway[J]. J Huazhong Univ Sci Technol (Med Sci), 2014, 34(3): 363-369.
[14] Li H, Yu B, Li J, et al.Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer[J]. Oncotarget, 2014, 5(8): 2318-2329.
[15] Zhou X, Ye F, Yin C, et al.The interaction between MiR-141 and lncRNA-H19 in regulating cell pro-liferation and migration in gastric cancer[J]. Cell Physiol Biochem, 2015, 36(4): 1440-1452.
[16] Zhang HM, Yang FQ, Chen SJ, et al.Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma[J]. Tumour Biol, 2015, 36(4): 2947-2955.
[17] Jadaliha M, Zong X, Malakar P, et al.Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative ly-mph node negative breast cancer[J]. Oncotarget, 2016, 7(26): 40418-40436.
[18] Wang W, Zhu Y, Li S, et al.Long noncoding RNA MALAT1 promotes malignant development of eso-phageal squamous cell carcinoma by targeting β- catenin via Ezh2[J]. Oncotarget, 2016, 7(18): 25668-25682.
[19] Dong Y, Liang G, Yuan B, et al.MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway[J]. Tumour Biol, 2015, 36(3): 1477-1486.
[20] Hauptman N, Glavač D.Long non-coding RNA in cancer[J]. Int J Mol Sci, 2013, 14(3): 4655-4669.
[21] Endo H, Shiroki T, Nakagawa T, et al.Enhanced ex- pression of long non-coding RNA HOTAIR is asso-ciated with the development of gastric cancer[J]. PLoS One, 2013, 8(10): e77070.
[22] Huang J, Ke P, Guo L, et al.Lentivirus-mediated RNA interference targeting the long noncoding RNA HOTAIR inhibits proliferation and invasion of en-dometrial carcinoma cells in vitro and in vivo[J]. Int J Gynecol Cancer, 2014, 24(4): 635-642.
[23] Fang K, Liu P, Dong S, et al.Magnetofection based on superparamagnetic iron oxide nanoparticle-me-diated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells[J]. Int J Oncol, 2016, 49(2): 509-518.
[24] Gutschner T, Diederichs S.The hallmarks of cancer: a long non-coding RNA point of view[J]. RNA Biol, 2012, 9(6): 703-719.
[25] Peng W, Wu G, Fan H, et al.Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and pro-motes tumorigenesis in gastric cancer[J]. Tumour Biol, 2015, 36(9): 6751-6758.
[26] Jing W, Gao S, Zhu M, et al.Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular car-cinoma[J]. Oncol Rep, 2016, 36(2): 1085-1092.
[27] Smith CM, Steitz JA.Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5’-terminal oligopyrimidine gene family reveals common features of snoRNA host genes[J]. Mol Cell Biol, 1998, 18(12): 6897-6909.
[28] Pickard MR, Mourtada-Maarabouni M, Williams GT.Long non-coding RNA GAS5 regulates apop-tosis in prostate cancer cell lines[J]. Biochim Biophys Acta, 2013, 1832(10): 1613-1623.
[29] Liu Z, Wang W, Jiang J, et al.Downregulation of GAS5 promotes bladder cancer cell proliferation, partly byregulating CDK6[J]. PLoS One, 2013, 8(9): e73991.
[30] Chen L, Yang H, Xiao Y, et al.Lentiviral-mediated overexpression of long non-coding RNA GAS5 re-duces invasion by mediating MMP2 expression and activity in human melanoma cells[J]. Int J Oncol, 2016, 48(4): 1509-1518.
[31] Lu KH, Li W, Liu XH, et al.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and in-duces apoptosis by affecting p53 expression[J]. BMC Cancer, 2013, 13: 461.
[32] Qin R, Chen Z, Ding Y, et al.Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis[J]. Neoplasma, 2013, 60(5): 486-492.
[33] Chang L, Wang G, Jia T, et al.Armored long non-coding RNA MEG3 targeting EGFR based on re-combinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma[J]. Oncotarget, 2016, 7(17): 23988-24004.
[34] Flockhart RJ, Webster DE, Qu K, et al.BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration[J]. Genome Res, 2012, 22(6): 1006-1014.
[35] Sun M, Liu XH, Wang KM, et al.Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesen-chymal transition[J]. Mol Cancer, 2014, 13(1): 68.
[36] Gibb EA, Enfield KS, Stewart GL, et al.Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions[J]. Oral Oncol, 2011, 47(11): 1055-1061.
[37] Wu Y, Zhang L, Zhang L, et al.Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E- cadherin in oral squamous cell carcinoma[J]. Int J Oncol, 2015, 46(6): 2586-2594.
[38] Jia LF, Wei SB, Gan YH, et al.Expression, regula-tion and roles of miR-26a and MEG3 in tongue squa-mous cell carcinoma[J]. Int J Cancer, 2014, 135(10): 2282-2293.
[39] Gao W, Chan JY, Wong TS.Long non-coding RNA deregulation in tongue squamous cell carcinoma[J].Biomed Res Int, 2014, 2014: 405860.
[1] 李媛媛,程斌,王韵. 长链非编码RNA lnc-p26090对口腔鳞状细胞癌细胞糖酵解及增殖的影响[J]. 国际口腔医学杂志, 2018, 45(6): 628-634.
[2] 王伊婷,何永文. 口腔鳞状细胞癌相关长链非编码RNA调控肿瘤细胞上皮-间充质转化的研究进展[J]. 国际口腔医学杂志, 2018, 45(6): 635-639.
[3] 韩曈曈,陈乔尔,朱友明. p53相关长链非编码RNA及其与口腔癌的关系[J]. 国际口腔医学杂志, 2018, 45(5): 597-602.
[4] 葛逸弘, 房付春, 吴补领. 长链非编码RNA在间充质干细胞多向分化过程中的调节作用[J]. 国际口腔医学杂志, 2018, 45(3): 267-271.
[5] 肖妍荻, 杨华梅, 但红霞. 抗肿瘤靶向药物相关不良反应在口腔中的表现及处理对策[J]. 国际口腔医学杂志, 2018, 45(2): 140-144.
[6] 刘航航, 罗恩. 手术机器人在颅颌面非肿瘤性疾病治疗中的应用[J]. 国际口腔医学杂志, 2018, 45(1): 85-90.
[7] 王志强, 马丽娟, 周海静, 杨兰, 聂红兵, 薛龙. 益生菌抗肿瘤作用及其机制的研究进展[J]. 国际口腔医学杂志, 2017, 44(6): 636-641.
[8] 梁静, 王凯, 吴家媛. CD24在口腔医学中的研究进展[J]. 国际口腔医学杂志, 2017, 44(5): 608-613.
[9] 李龙,黄洪章. 微小RNA-205在肿瘤化学治疗耐药中的作用和机制[J]. 国际口腔医学杂志, 2016, 43(6): 734-738.
[10] 耿奉雪,潘亚萍. 微小RNA-203的生物学功能及其在口腔疾病中的作用[J]. 国际口腔医学杂志, 2016, 43(6): 685-689.
[11] 刘盼1,多力昆?吾甫尔1,蔡志刚2,孙坚3. 维吾尔族口腔鳞状细胞癌患者中血清鳞状细胞癌抗原的表达研究[J]. 国际口腔医学杂志, 2016, 43(6): 645-650.
[12] 陈冠辉 侯劲松. 低氧和自噬与肿瘤的发生发展[J]. 国际口腔医学杂志, 2016, 43(5): 584-588.
[13] 陈冬茹 吴莉萍. 低氧诱导因子-1α和反义低氧诱导因子-1α的研究进展[J]. 国际口腔医学杂志, 2016, 43(5): 589-593.
[14] 陈甜,白丁. 骨硬化蛋白对牙骨质形成的影响及其机制[J]. 国际口腔医学杂志, 2016, 43(3): 333-337.
[15] 徐巾诏1 蓝菁2 汲平2. 卷曲蛋白在无翅型小鼠乳房肿瘤病毒整合位点家族-卷曲蛋白信号转导通路中的作用[J]. 国际口腔医学杂志, 2016, 43(1): 85-.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张京剧. 青年期至中年期颅面复合体变化的头影测量研究[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 刘玲. 镍铬合金中铍对可铸造性和陶瓷金属结合力的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 修补颌骨缺损的新型生物学相容材料[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 王昆润. 咀嚼口香糖对牙周组织微循环的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[6] 宋红. 青少年牙周炎外周血分叶核粒细胞的趋化功能[J]. 国际口腔医学杂志, 1999, 26(06): .
[7] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[8] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[9] 王金涛 刘美娟 孙宏晨 欧阳喈. 牙槽嵴牵张成骨[J]. 国际口腔医学杂志, 2004, 31(02): 146 -148 .
[10] 杨儒壮 孙宏晨 欧阳喈. 纳米级高分子支架材料在组织工程中的研究进展[J]. 国际口腔医学杂志, 2004, 31(02): 126 -128 .