国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 286-290.doi: 10.7518/gjkq.2018.03.008

• 干细胞专栏 • 上一篇    下一篇

Wnt信号通路在调控牙髓干细胞多向分化及炎症损伤修复中的作用

杨鑫, 李思洁, 赵玮   

  1. 中山大学光华口腔医学院•附属口腔医院儿童口腔科 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2017-06-06 修回日期:2017-11-29 发布日期:2018-05-08
  • 通讯作者: 赵玮,主任医师,博士,Email：zhaowei3@mail.sysu.edu.cn
  • 作者简介:杨鑫,硕士,Email：yangx237@mail2.sysu.edu.cn
  • 基金资助:
    广东省科技计划项目（2016A020215094）;广东省自然科学基金（2014A030313126）

Wnt signaling pathway mediates the dental pulp stem cells in multipotential differentiation and inflammatory microenvironment

Yang Xin, Li Sijie, Zhao Wei   

  1. Dept. of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2017-06-06 Revised:2017-11-29 Published:2018-05-08
  • Supported by:
    This study was supported by Science and Technology Planning Project of Guangdong Province (2016A020215094) and Natural Science Foundation of Guangdong Province (2014A030313126).

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摘要： 人牙髓干细胞（hDPSC）和乳牙牙髓干细胞（SHED）均属于间充质干细胞,具有多向分化潜能。Wnt信号通路包括经典Wnt/β-catenin信号通路和非经典Wnt信号通路,参与牙齿的生长发育过程,能促进牙损伤的修复。在炎症状态下,激活的Wnt信号通路可加快牙损伤修复,参与hDPSC的增殖与成牙本质向分化过程。在非炎症状态下,Wnt信号通路参与调控hDPSC和SHED成骨、成牙本质方向分化,抑制其成脂向分化。

关键词: Wnt信号通路, 牙髓干细胞, 乳牙牙髓干细胞, 分化

Abstract: Human dental pulp stem cell (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) are human mesenchymal stem cells demonstrating multipotential differentiation capabilities. The Wnt signaling pathway consists of canonical Wnt/β-catenin and noncanonical Wnt signal pathways, which are activated during tooth morphogenesis. These pathways also play key roles in the dental pulp repair process. During inflammation, an activated Wnt signal pathway plays a significant role in the process involved in the repair of a damaged tooth. This pathway also participates in hDPSC proliferation and odontoblastic differentiation. In non-inflammatory conditions, hDPSC and SHED differentiate into osteoblasts and odontoblasts, respectively, which suppress adipogenic differentiation through the Wnt signaling pathway.

Key words: Wnt signaling pathway, dental pulp stem cell, stem cells from human exfoliated deciduous teeth, differentiation

中图分类号: 

  • Q257
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