国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (3): 263-269.doi: 10.7518/gjkq.2020033

• 间充质干细胞专栏 • 上一篇    下一篇

RNA腺嘌呤6-甲基化修饰调控骨髓间充质干细胞成骨向分化的研究进展

刘俊圻,陈艺尹,杨文宾()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔颌面外科 成都 610041
  • 收稿日期:2019-08-13 修回日期:2019-11-29 出版日期:2020-05-01 发布日期:2020-05-08
  • 通讯作者: 杨文宾
  • 作者简介:刘俊圻,学士,Email：609591179@qq.com
  • 基金资助:
    四川大学华西口腔医院探索与研发项目(RD-02-201907)

Research progress on N6-methyladenosine for regulating the osteogenic differentiation of bone marrow mesenchymal stem cells

Liu Junqi,Chen Yiyin,Yang Wenbin()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-08-13 Revised:2019-11-29 Online:2020-05-01 Published:2020-05-08
  • Contact: Wenbin Yang
  • Supported by:
    Research and Development Foundation of West China Hospital of Stomatology, Sichuan University(RD-02-201907)

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摘要：

RNA腺嘌呤6-甲基化修饰是真核生物信使RNA和非编码RNA上最为常见的一种表观遗传修饰,对于真核生物多项生命活动的调控起着至关重要的作用。近来的研究发现,RNA腺嘌呤6-甲基化修饰在骨髓间充质干细胞的分化,尤其是成骨向分化上,扮演着十分重要的角色。本文通过对RNA腺嘌呤6-甲基化修饰调控骨髓间充质干细胞成骨向分化的相关研究加以总结,以期为后续基础研究以及临床应用提供新的思路。

关键词: 6-甲基腺嘌呤, RNA修饰, 成骨向分化, 间充质干细胞

Abstract:

RNA N6-methylation of adenosine is the most prevalent epigenetic modification of messenger and noncoding RNAs in eukaryotes and plays an important role in various biological processes. Recent studies demonstrated that RNA N6-methyladenosine has profound effect on bone marrow mesenchymal stem cell differentiation, especially in osteogenic differentiation. In this paper, we review related studies to provide new strategies for follow-up basic research and clinical applications.

Key words: N 6-methyladenosine, RNA modification, osteogenic differentiation, mesenchymal stem cell

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  • Q254
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