国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 272-275.doi: 10.7518/gjkq.2018.03.005

• 干细胞专栏 • 上一篇    下一篇

RNA腺嘌呤6-甲基化修饰调控干细胞分化的研究进展

武云舒, 袁泉   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科 成都 610041
  • 收稿日期:2017-10-14 修回日期:2018-01-08 发布日期:2018-05-08
  • 通讯作者: 袁泉,教授,博士,Email：yuanquan@scu.edu.cn
  • 作者简介:武云舒,硕士,Email：sophiawu0624@163.com
  • 基金资助:
    国家自然科学基金（81722014）;四川省科技创新团队项目（2017TD0016）

Regulation of RNA N6-methylation of adenosine on stem cell differentiation

Wu Yunshu, Yuan Quan   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-10-14 Revised:2018-01-08 Published:2018-05-08
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81722014) and Sichuan Province Science and Technology Innovation Team Program (2017TD0016) .

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摘要： 腺嘌呤甲基化形成6-甲基腺嘌呤（m6A）是真核生物中最为常见的一种RNA转录后修饰,参与众多基因的表达及细胞活动中复杂而精细的生物学调控。腺嘌呤的6-甲基化是一种动态可逆性过程,甲基转移酶Mettl3、Mettl14和Wtap催化m6A的生成,而去甲基化酶FTO和ALKBH5可以催化m6A去除甲基。近年来的研究发现,甲基转移酶和去甲基化酶可以通过在RNA上“书写”或“擦除”m6A标记来调控干细胞的多能性和分化,为RNA表观遗传学调控干细胞命运提供了新的研究角度。

关键词: 6-甲基腺嘌呤, 甲基转移酶, 去甲基化酶, 干细胞分化, 多能性

Abstract: N6-methylation of adenosine is the most prevalent post-transcriptional RNA modification in eukaryotes. Mettl3, Mettl14 and Wtap are methyltransferases that catalyse the formation of N6-methyladenosine (m6A). Demethylase, FTO and ALKBH5 can remove the methyl of m6A, thereby rendering a dynamic and reversible m6A modification. Methyltransferases and demethylases can regulate the pluripotency and differentiation of stem cells through writing and erasure of m6A marks on RNA. These data provide a novel dimension in epigenetic regulation at the RNA level to affect stem cell fate.

Key words: N6-methyladenosine, methyltransferase, demethylase, stem cell differentiation, pluripotency

中图分类号: 

  • Q753
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