国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 261-266.doi: 10.7518/gjkq.2018.03.003

• 干细胞专栏 • 上一篇    下一篇

牙髓干细胞的表观遗传调控

张鑫, 汪成林, 杨静, 叶玲   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2017-08-07 修回日期:2017-12-15 发布日期:2018-05-08
  • 通讯作者: 叶玲,教授,博士,Email:yeling@scu.edu.cn
  • 作者简介:张鑫,硕士,Email:zhangxin0926@126.com
  • 基金资助:
    国家国际科技合作专项项目(2014DFA31990)

Epigenetic regulation in dental pulp stem cells

Zhang Xin, Wang Chenglin, Yang Jing, Ye Ling   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-08-07 Revised:2017-12-15 Published:2018-05-08
  • Supported by:
    This study supported by International Science & Technology Cooperation Program of China (2014DFA31990).

摘要: 牙髓干细胞是牙髓组织中具有自我更新能力及多向分化潜能的一类成体干细胞,在牙髓修复、牙齿再生以及骨组织工程中发挥重要作用。表观遗传是指在DNA序列不改变的前提下基因表达发生了可遗传的变化,主要包括DNA甲基化、组蛋白修饰、非编码RNA调控等。研究发现,通过调控基因的转录过程,表观调控在牙髓干细胞的各项生物学行为中起着重要作用。本文对牙髓干细胞的表观遗传调控进行综述。

关键词: 表观遗传, 牙髓干细胞, DNA甲基化, 组蛋白修饰, 非编码RNA

Abstract: Dental pulp stem cells (DPSCs) are adult stem cells with self-renewal ability and multiple differentiation potential. These cells play an important role in dental pulp repair, tooth regeneration, and bone tissue engineering. Epigenetics refers to heritable changes in gene expression without alteration of DNA sequence; these changes include DNA methylation, histone modification, and non-coding RNA regulation. Epigenetic modification plays an important role in regulation of DPSCs by influencing gene transcription. Thus, this study aims to elaborate epigenetic regulations of DPSCs.

Key words: epigenetic, dental pulp stem cell, DNA methylation, histone modification, non-coding RNA

中图分类号: 

  • Q756
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