国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 437-441.doi: 10.7518/gjkq.2019050

• 综述 • 上一篇    下一篇

DNA甲基化与口腔疾病的研究进展

原振英1,管翠强2,南欣荣1,2()   

  1. 1. 山西医科大学口腔医学院·口腔医院 太原 030001;
    2. 山西医科大学第一医院口腔科 太原 030001
  • 收稿日期:2018-11-29 修回日期:2019-04-06 出版日期:2019-07-01 发布日期:2019-07-12
  • 作者简介:原振英,学士,Email： 853951775@qq.com
  • 基金资助:
    山西省卫生和计划生育委员会科研课题(2015026)

Research progress on DNA methylation and oral disease

Yuan Zhenying1,Guan Cuiqiang2,Nan Xinrong1,2()   

  1. 1. School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Stomatology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2018-11-29 Revised:2019-04-06 Online:2019-07-01 Published:2019-07-12
  • Supported by:
    This study was supported by Scientific Research Project of Shanxi Health and Family Planning Commission(2015026)

RichHTML

23

PDF (PC)

627

摘要：

DNA甲基化现在被广泛认为是维持免疫细胞功能的关键。异常的DNA甲基化水平与常见的口腔疾病相关。环境因素和遗传多态性导致甲基化异常,影响某些免疫相关基因的表达,成为研究口腔疾病机制的热点。本文综述了在慢性牙周炎、口腔癌、口腔扁平苔藓等常见口腔疾病发展过程中异常甲基化的重要性,以及DNA甲基化与复发性阿弗他溃疡关系的研究展望,目的是更清楚地了解口腔疾病的发病机制,从而为治疗复杂性口腔疾病提供新的思路。

关键词: DNA甲基化, 慢性牙周炎, 口腔癌, 口腔扁平苔藓

Abstract:

DNA methylation is the key to maintaining the function of immune cells. Recent studies have shown that abnormal DNA methylation levels are significantly associated with common oral diseases. Environmental factors and genetic polymorphism lead to abnormal methylation and affect the expression of some immune-related genes. This paper reviewed the importance of abnormal DNA methylation in the development of common oral diseases (e.g. chronic periodontitis, oral cancer and oral lichen planus) and the relationship between DNA methylation and recurrent aphthous ulcer. This paper provides improved understanding of the pathogenesis of oral diseases and new insights into the treatment of oral diseases.

Key words: DNA methylation, chronic periodontitis, oral cancer, oral lichen planus

中图分类号: 

  • Q754
[1] Gluckman PD . Epigenetics and metabolism in 2011: epigenetics, the life-course and metabolic disease[J]. Nat Rev Endocrinol, 2011,8(2):74-76.
[2] Quintero-Ronderos P, Montoya-Ortiz G . Epigenetics and autoimmune diseases[J]. Autoimmune Dis, 2012,2012:593720.
[3] Kim H, Wang X, Jin P . Developing DNA methylation-based diagnostic biomarkers[J]. J Genet Genomics, 2018,45(2):87-97.
[4] Rodriguez RM, Lopez-Larrea C, Suarez-Alvarez B . Epigenetic dynamics during CD4 + T cells lineage commitment [J]. Int J Biochem Cell Biol, 2015,67:75-85.
[5] Zhang S, Barros SP, Moretti AJ , et al. Epigenetic regulation of TNFA expression in periodontal disease[J]. J Periodontol, 2013,84(11):1606-1616.
[6] Dor Y, Cedar H . Principles of DNA methylation and their implications for biology and medicine[J]. Lancet, 2018,392(10149):777-786.
[7] Sun B, Hu L, Luo ZY , et al. DNA methylation perspectives in the pathogenesis of autoimmune diseases[J]. Clin Immunol, 2016,164:21-27.
[8] Jin Z, Liu Y . DNA methylation in human diseases[J]. Genes Dis, 2018,5(1):1-8.
[9] Deaton AM, Bird A . CpG islands and the regulation of transcription[J]. Genes Dev, 2011,25(10):1010-1022.
[10] Williams K, Christensen J, Helin K . DNA methylation: TET proteins-guardians of CpG islands[J]. EMBO Rep, 2011,13(1):28-35.
[11] Tahara T, Shibata T, Arisawa T , et al. CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer[J]. Anticancer Res, 2010,30(1):239-244.
[12] 史玉杰, 李庆贺, 刘晓辉 . DNA甲基化与基因表达调控研究进展[J]. 中国生物工程杂志, 2013,33(7):90-96.
Shi YJ, Li QH, Liu XH . Progress in studies of DNA methylation and gene expression regulation[J]. Chin Biotechnol, 2013,33(7):90-96.
[13] Singh A, Gill G, Jakhu H . Epigenetics and its implications for oral health[J]. J Oral Biosci, 2018,60(2):41-48.
[14] Abiko Y, Uehara O, Fukumoto S , et al. Epigenetics of oral infection and inflammatory diseases—DNA methylation changes in infections and inflammation diseases[J]. J Oral Biosci, 2014,56(4):105-109.
[15] 唐秋玲, 李格格, 潘佳慧 , 等. 细胞焦亡与牙龈卟啉单胞菌的关系及其在牙周病发生发展中的作用机制[J]. 国际口腔医学杂志, 2017,44(6):660-663.
Tang QL, Li GG, Pan JH , et al. Mechanism of pyroptosis and Porphyromonas gingivalis in periodontitis development process[J]. Int J Stomatol, 2017,44(6):660-663.
[16] Stefani FA, Viana MB, Dupim AC , et al. Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues[J]. Immunobiology, 2013,218(7):1012-1017.
doi: 10.1016/j.imbio.2012.12.001
[17] Ahmadi M, Gharibi T, Dolati S , et al. Epigenetic mo-difications and epigenetic based medication implementations of autoimmune diseases[J]. Biomed Pharmacother, 2017,87:596-608.
[18] Viana MB, Cardoso FP, Diniz MG , et al. Methylation pattern of IFN-γ and IL-10 genes in periodontal tissues[J]. Immunobiology, 2011,216(8):936-941.
doi: 10.1016/j.imbio.2011.01.006
[19] Zhang S, Crivello A, Offenbacher S , et al. Interferon- γ promoter hypomethylation and increased expression in chronic periodontitis[J]. J Clin Periodontol, 2010,37(11):953-961.
[20] Nikitakis NG, Rassidakis GZ, Tasoulas J , et al. Alterations in the expression of DNA damage response-related molecules in potentially preneoplastic oral epithelial lesions[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2018,125(6):637-649.
[21] Sankaranarayanan R, Sauvaget C, Ramadas K , et al. Clinical trials of cancer screening in the developing world and their impact on cancer healthcare[J]. Ann Oncol, 2011,22(Suppl 7): vii20-vii28.
[22] Towle R, Truong D, Hogg K , et al. Global analysis of DNA methylation changes during progression of oral cancer[J]. Oral Oncol, 2013,49(11):1033-1042.
doi: 10.1016/j.oraloncology.2013.08.005
[23] Arantes LM, de Carvalho AC, Melendez ME , et al. Validation of methylation markers for diagnosis of oral cavity cancer[J]. Eur J Cancer, 2015,51(5):632-641.
[24] Breitling LP, Yang R, Korn B , et al. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication[J]. Am J Hum Genet, 2011,88(4):450-457.
doi: 10.1016/j.ajhg.2011.03.003
[25] Dang J, Bian YQ, Sun JY , et al. MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma[J]. J Oral Pathol Med, 2013,42(4):315-321.
doi: 10.1111/jop.12012
[26] Cao J, Zhou J, Gao Y , et al. Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study[J]. Clin Cancer Res, 2009,15(16):5178-5183.
[27] Liu H, Liu XW, Dong G , et al. P16 methylation as an early predictor for cancer development from oral epithelial dysplasia: a double-blind multicentre prospective study[J]. EBioMedicine, 2015,2(5):432-437.
[28] 刘雅菁, 王文梅 . 口腔扁平苔藓中T淋巴细胞亚群的研究进展[J]. 国际口腔医学杂志, 2011,38(4):433-435.
Liu YJ, Wang WM . Research progress on T lymphocyte subsets of oral lichen planus[J]. Int J Stomatol, 2011,38(4):433-435.
[29] Fonseca-Silva T, Oliveira MV, Fraga CA , et al. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus[J]. Pathobiology, 2012,79(1):18-23.
doi: 10.1159/000330171
[30] Cruz AF, de Resende RG, de Lacerda JCT , et al. DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus[J]. J Oral Pathol Med, 2018,47(1):91-95.
[31] 陈谦明, 周曾同 . 口腔黏膜病学[M]. 3版. 北京: 人民卫生出版社, 2008.
Chen QM, Zhou ZT. Oral mucosa diseases[M]. 3rd ed. Beijing: People’s Health Publishing House, 2008.
[32] 管翠强, 武云霞, 郭洪波 . 复发性口腔溃疡血清叶酸和维生素B12的临床观察[J]. 山西医科大学学报, 2014,45(5):395-397.
Guan CQ, Wu YX, Guo HB . Clinical observation on serum folic acid and vitamin B12 in patients with recurrent oral ulcer[J]. J Shanxi Med Univ, 2014,45(5):395-397.
[33] 刘好好, 许子悦, 谢春雨 , 等. 复发性口腔溃疡与T细胞免疫研究进展[J]. 现代免疫学, 2016,36(1):72-75.
Liu HH, Xu ZY, Xie CY , et al. Recurrent oral ulcer and T cell immunity[J]. Curr Immunol, 2016,36(1):72-75.
[34] 郭洪波, 管翠强 . 加味导赤散对复发性口腔溃疡患者Th1/Th2平衡的调节作用[J]. 中国药物与临床, 2015,15(12):1745-1747.
Guo HB, Guan CQ . Regulatory effect of Jiawei Daochi Powder on Th1/Th2 balance in patients with recurrent oral ulcer[J]. Chin Remed Clin, 2015,15(12):1745-1747.
[35] 杜芹, 田鲲, 廖楚航 . 复发性阿弗他溃疡Th1/Th2细胞因子的检测[J]. 成都医学院学报, 2013,8(6):657-660.
Du Q, Tian K, Liao CH . Expression of Thl/Th2-related cytokines in recurrent Aphthous ulcers[J]. J Chengdu Med Coll, 2013,8(6):657-660.
[36] Lewkowicz N, Kur B, Kurnatowska A , et al. Expression of Th1/Th2/Th3/Th17-related genes in recurrent aphthous ulcers[J]. Arch Immunol Ther Exp (Warsz), 2011,59(5):399-406.
[37] Bird JJ, Brown DR, Mullen AC , et al. Helper T cell differentiation is controlled by the cell cycle[J]. Immunity, 1998,9(2):229-237.
[38] Brand S, Kesper DA, Teich R , et al. DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma[J]. J Allergy Clin Immunol, 2012,129(6):1602-1610.
[1] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[2] 李然,胡月,张宁,高瑞芳,王翔宇,葛学军. Toll样受体和白细胞介素-17单核苷酸多态性与口腔扁平苔藓易感性的相关性研究[J]. 国际口腔医学杂志, 2024, 51(1): 45-51.
[3] 王素杰,谭芹,韦渊,王洁,范杰,岳二丽. 口腔扁平苔藓患者血清血管生成素-2水平与叉头翼状螺旋转录因子阳性调节性T细胞及疾病活动度的相关性分析[J]. 国际口腔医学杂志, 2023, 50(6): 674-678.
[4] 姜玥莹,何宇添,李婷,周蓉卉. 近红外荧光探针在口腔癌诊断中应用的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 407-413.
[5] 范琳,孙江. 微针在口腔医学中的应用[J]. 国际口腔医学杂志, 2023, 50(4): 472-478.
[6] 何静,胡明佳,肖宁,李佳,孙婉昕,吕凌,刘帆. 口腔扁平苔藓患者心理痛苦程度及影响因素的调查研究[J]. 国际口腔医学杂志, 2023, 50(3): 308-313.
[7] 林慧平,徐婷,林军. 人工智能在口腔癌和口腔潜在恶性疾病诊断中的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 138-145.
[8] 王太萍,石兴莲,李喆臻,刘梅,姜健红. 口腔癌患者心理因素及干预现状分析[J]. 国际口腔医学杂志, 2023, 50(2): 203-209.
[9] 张沈懿,王翔剑,石黎冉,石佳鸿,汪玉红,周红梅. 口服β-胡萝卜素治疗非糜烂型口腔扁平苔藓的随机对照试验研究[J]. 国际口腔医学杂志, 2022, 49(6): 633-640.
[10] 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599.
[11] 陈思婷,钟雄,孟文霞. Nod样受体家族嘌呤结构域3炎症小体在口腔黏膜病中的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 471-475.
[12] 刘思宇,李新,徐晓雨,孙银银,潘英潇,王赛男,卢恕来. 口腔扁平苔藓与心血管疾病相关性的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 141-146.
[13] 冯璐,孟文霞. 常见口腔黏膜疾病患者行种植修复相关问题的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 147-155.
[14] 漆晓玲,甘廷彬,黄姣. 慢性牙周炎和慢性肾病相关关系的研究进展[J]. 国际口腔医学杂志, 2021, 48(1): 18-22.
[15] 沈晨露,叶伟佳,吕柯佳,高碧聪,姚华. 口腔扁平苔藓实验模型建立的研究进展[J]. 国际口腔医学杂志, 2020, 47(1): 58-62.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 修补颌骨缺损的新型生物学相容材料[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 陆加梅. 不可复性关节盘移位患者术前张口度与关节镜术后疗效的相关性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 咀嚼口香糖对牙周组织微循环的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 宋红. 青少年牙周炎外周血分叶核粒细胞的趋化功能[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[6] 侯锐. 正畸患者釉白斑损害的纵向激光荧光研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 轩东英. 不同赋形剂对氢氧化钙抗菌效果的影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[8] 房兵. 唇腭裂新生儿前颌骨矫正方法及对上颌骨生长发育的影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[9] 杨美祥. 前牙厚度在预测上下颌牙量协调性中的作用[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 赵艳丽. 手术刀、电凝、CO_2和KTP激光对大鼠舌部创口的作用[J]. 国际口腔医学杂志, 1999, 26(04): .