国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (1): 58-62.doi: 10.7518/gjkq.2020028

• 口腔黏膜专栏 • 上一篇    下一篇

口腔扁平苔藓实验模型建立的研究进展

沈晨露,叶伟佳,吕柯佳,高碧聪,姚华()   

  1. 浙江大学医学院附属第一医院口腔科 杭州 310003
  • 收稿日期:2019-04-14 修回日期:2019-10-06 出版日期:2020-01-01 发布日期:2020-01-01
  • 通讯作者: 姚华
  • 作者简介:沈晨露,硕士,Email： 21818728@zju.edu.cn
  • 基金资助:
    国家自然科学基金(81101660)

Research progress on experimental model establishment of oral lichen planus

Shen Chenlu,Ye Weijia,Lü Kejia,Gao Bicong,Yao Hua()   

  1. Dept. of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2019-04-14 Revised:2019-10-06 Online:2020-01-01 Published:2020-01-01
  • Contact: Hua Yao
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81101660)

RichHTML

32

PDF (PC)

747

摘要：

口腔扁平苔藓是一种最常见的口腔黏膜慢性炎症性疾病,临床上缺乏有效的治疗措施。寻找和建立合适的实验模型对开展口腔扁平苔藓诊治研究有着重要的意义,但因口腔扁平苔藓的发病原因和机制未明,给实验模型的建立带来困难,是目前口腔学者面临的难题之一。迄今为止,国内外尚未建立完善的口腔扁平苔藓动物模型,而相关细胞模型已较为成熟,本文就目前口腔扁平苔藓实验模型的研究进展进行综述。

关键词: 口腔扁平苔藓, 动物模型, 细胞模型

中图分类号: 

  • R781.5
[1] Giannetti L, Dello Diago AM, Spinas E . Oral lichen planus[J]. J Biol Regul Homeost Agents, 2018,32(2):391-395.
[2] Rivera C, Jones-Herrera C, Vargas P , et al. Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries[J]. Med Oral Patol Oral Cir Bucal, 2017,22(3):e297-e306.
[3] Nosratzehi T . Oral lichen planus: an overview of potential risk factors, biomarkers and treatments[J]. Asian Pac J Cancer Prev, 2018,19(5):1161-1167.
[4] Diebold S, Overbeck M . Soft tissue disorders of the mouth[J]. Emerg Med Clin N Am, 2019,37(1):55-68.
[5] Cao T, Zhang H, Zhou L , et al. In vitro cell culture system optimization of keratinocytes from oral lichen planus (OLP) patients[J]. Oral Dis, 2017,23(2):225-232.
[6] Olson MA , Rogers RS 3rd,Bruce AJ.Oral lichen planus[J]. Clin Dermatol, 2016,34(4):495-504.
[7] Lauritano D, Arrica M, Lucchese A , et al. Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis[J]. Head Face Med, 2016,12:18.
[8] Giuliani M, Troiano G, Cordaro M , et al. Rate of malignant transformation of oral lichen planus: a systematic review[J]. Oral Dis, 2019,25(3):693-709.
[9] 汪群, 诸焕颖, 孙红英 . 人口腔扁平苔藓角质形成细胞的体外培养及生物学鉴定[J]. 复旦学报(医学版), 2007,34(5):776-779, 784.
Wang Q, Zhu HY, Sun HY . Culture and biological identification of human oral lichen planus keratino-cytes in vitro[J]. Fudan Univ J Med Sci, 2007,34(5):776-779, 784.
[10] Sun HY, Zhou GM, Wang Q , et al. In vitro culture system for keratinocytes obtained from oral lichen planus lesions[J]. Clin Oral Investig, 2014,18(4):1195-1203.
[11] Xu N, Li BY, Liu ZZ , et al. Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus[J]. Oral Dis, 2019,25(4):1091-1099.
[12] Ge XJ, Wang LX, Li MD , et al. Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway[J]. Cell Commun Signal, 2019,17(1):18.
[13] Wilson VG . Growth and differentiation of HaCaT keratinocytes[J]. Methods Mol Biol, 2014,1195:33-41.
[14] Zhao B, Li R, Yang F , et al. LPS-induced vitamin D receptor decrease in oral keratinocytes is associated with oral lichen planus[J]. Sci Rep, 2018,8(1):763.
[15] Wang YN, Zhang H, Du GH , et al. Total glucosides of paeony (TGP) inhibits the production of inflammatory cytokines in oral lichen planus by suppressing the NF-κB signaling pathway[J]. Int Immunopharmacol, 2016,36:67-72.
[16] Du J, Li R, Yu F , et al. Experimental study on 1,25(OH)2 D3 amelioration of oral lichen planus through regulating NF-κB signaling pathway[J]. Oral Dis, 2017,23(6):770-778.
[17] Gotoh A, Hamada Y, Shiobara N , et al. Skew in T cell receptor usage with polyclonal expansion in lesions of oral lichen planus without hepatitis C virus infection[J]. Clin Exp Immunol, 2008,154(2):192-201.
[18] 李琴, 杜观环, 唐国瑶 . 口腔扁平苔藓相关细胞模型的建立[J]. 上海口腔医学, 2011,20(1):16-20.
Li Q, Du GH, Tang GY . Establishment of a correla-ted cell model of oral lichen planus in vitro[J]. Shan-ghai J Stomatol, 2011,20(1):16-20.
[19] Du GH, Qin XP, Li Q , et al. The high expression level of programmed death-1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells[J]. J Oral Pathol Med, 2011,40(7):525-532.
[20] 孙晓爽, 何虹, 刘巍 , 等. 常见口腔黏膜病动物模型研究进展[J]. 口腔医学, 2018,38(4):380-384.
Sun XS, He H, Liu W , et al. Research progress of animal models of commonoral mucosal diseases[J]. Stomatology, 2018,38(4):380-384.
[21] Tammi R, Hyyryläinen A, Fräki JE . Histologic characteristics of lichen planus transplanted onto nude mice and cultured in vitro[J]. Arch Dermatol Res, 1988,280(1):23-28.
[22] 杨灵澜, 叶萍, 马莉 , 等. 口腔扁平苔藓移植严重联合免疫缺陷小鼠的实验研究[J]. 实用口腔医学杂志, 2005,21(2):210-213.
Yang LL, Ye P, Ma L , et al. Preliminary study on xenografts of oral lichen planus tissue into SCID mice[J]. J Pract Stomatol, 2005,21(2):210-213.
[23] 董鑫 . 口腔扁平苔藓动物模型的建立及口腔扁平苔藓患者唾液酶、IL-18的检测及临床意义[D]. 石家庄: 河北医科大学, 2014.
Dong X . Establishment of animal model of oral lichen planus and the detection and clinical significance of salivary enzymes, IL-18 in patients with oral lichen planus[D]. Shijiazhuang: Hebei Medical University, 2014.
[24] 胡维力 . 口腔扁平苔藓动物模型的初步建立及化湿行瘀清热方治疗口腔扁平苔藓患者前后血清中差异蛋白的定量研究[D]. 石家庄: 河北医科大学, 2017.
Hu WL . Establishment of animal model of oral lichen planus and quantitative analysis of serum proteins in patients with OLP before and after treatment with prescription Huashi xingyu qingre decoction[D]. Shijiazhuang: Hebei Medical University, 2017.
[25] Di Stasio D, Guida A, Salerno C , et al. Oral lichen planus: a narrative review[J]. Front Biosci (Elite Ed), 2014,6:370-376.
[26] Kurago ZB . Etiology and pathogenesis of oral lichen planus: an overview[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016,122(1):72-80.
[27] Alrashdan MS, Cirillo N , McCullough M. Oral lichen planus: a literature review and update[J]. Arch Dermatol Res, 2016,308(8):539-551.
[28] Kemeny ME, Schedlowski M . Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression[J]. Brain Behav Immun, 2007,21(8):1009-1018.
[29] Wang YF, Shang S, Sun QQ , et al. Increased infiltration of CD11c +/CD123 + dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus[J].Oral Surg Oral Med Oral Pathol Oral Radiol, 2018, 125(5):459-467. e2.
[30] Santoro A, Majorana A, Roversi L , et al. Recruitment of dendritic cells in oral lichen planus[J]. J Pathol, 2005,205(4):426-434.
[31] Parolini S, Santoro A, Marcenaro E , et al. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues[J]. Blood, 2007,109(9):3625-3632.
[32] Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A , et al. Direct effects of type Ⅰ interferons on cells of the immune system[J]. Clin Cancer Res, 2011,17(9):2619-2627.
[33] 王宇峰, 齐渊元, 聂红 , 等. 口腔扁平苔藓损害组织中树突状细胞亚群数量和比例[J]. 临床口腔医学杂志, 2015,31(3):140-144.
Wang YF, Qi YY, Nie H , et al. A pilot study on dendritic cells’ subsets in oral lichen planus lesions[J]. J Clin Stomatol, 2015,31(3):140-144.
[34] 王宇峰, 唐国瑶 . 口腔扁平苔藓中树突状细胞的研究现状[J]. 临床口腔医学杂志, 2014,30(11):696-699.
Wang YF, Tang GY . Research status of dendritic cells in oral lichen planus[J]. J Clin Stomatol, 2014,30(11):696-699.
[35] Souto GR, Nunes LF, Tanure BB , et al. CD1a + dendritic cells in oral lichen planus and amalgam liche-noid reaction [J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016,121(6):651-656.
[1] 李然,胡月,张宁,高瑞芳,王翔宇,葛学军. Toll样受体和白细胞介素-17单核苷酸多态性与口腔扁平苔藓易感性的相关性研究[J]. 国际口腔医学杂志, 2024, 51(1): 45-51.
[2] 王素杰,谭芹,韦渊,王洁,范杰,岳二丽. 口腔扁平苔藓患者血清血管生成素-2水平与叉头翼状螺旋转录因子阳性调节性T细胞及疾病活动度的相关性分析[J]. 国际口腔医学杂志, 2023, 50(6): 674-678.
[3] 何静,胡明佳,肖宁,李佳,孙婉昕,吕凌,刘帆. 口腔扁平苔藓患者心理痛苦程度及影响因素的调查研究[J]. 国际口腔医学杂志, 2023, 50(3): 308-313.
[4] 张沈懿,王翔剑,石黎冉,石佳鸿,汪玉红,周红梅. 口服β-胡萝卜素治疗非糜烂型口腔扁平苔藓的随机对照试验研究[J]. 国际口腔医学杂志, 2022, 49(6): 633-640.
[5] 陈思婷,钟雄,孟文霞. Nod样受体家族嘌呤结构域3炎症小体在口腔黏膜病中的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 471-475.
[6] 刘思宇,李新,徐晓雨,孙银银,潘英潇,王赛男,卢恕来. 口腔扁平苔藓与心血管疾病相关性的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 141-146.
[7] 冯璐,孟文霞. 常见口腔黏膜疾病患者行种植修复相关问题的研究进展[J]. 国际口腔医学杂志, 2021, 48(2): 147-155.
[8] 原振英,管翠强,南欣荣. DNA甲基化与口腔疾病的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 437-441.
[9] 秦帅华,李新明,李文鹿. 有症状型口腔扁平苔藓患者生存质量与应对策略的评价和相关分析[J]. 国际口腔医学杂志, 2019, 46(3): 282-286.
[10] 房栗, 王翔, 王文梅. 吸烟相关疾病模型的研究进展[J]. 国际口腔医学杂志, 2017, 44(5): 587-590.
[11] 周毅 孙秀荣 刘学丽 闫世霞. 心理干预对口腔扁平苔藓治疗效果的影响[J]. 国际口腔医学杂志, 2016, 43(1): 22-.
[12] 王晓玲 朱敏. 人棕色脂肪细胞的研究进展[J]. 国际口腔医学杂志, 2016, 43(1): 103-.
[13] 杨文英1 张文丽1 罗应伟2. 颞下颌关节骨关节炎动物模型的研究进展[J]. 国际口腔医学杂志, 2015, 42(6): 677-680.
[14] 汪玉红 吴中婷 周红梅. 不同部位口腔扁平苔藓对治疗的不同反应1例[J]. 国际口腔医学杂志, 2015, 42(4): 430-431.
[15] 王夏夏 孙红英. 低氧诱导因子-1α与口腔扁平苔藓[J]. 国际口腔医学杂志, 2015, 42(3): 318-322.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张京剧. 青年期至中年期颅面复合体变化的头影测量研究[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 刘玲. 镍铬合金中铍对可铸造性和陶瓷金属结合力的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 在种植体上制作固定义齿以后下颌骨密度的动态变化[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 王昆润. 重型颌面部炎症死亡和康复病例的实验室检查指标比较[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 逄键梁. 两例外胚层发育不良儿童骨内植入种植体后牙槽骨生长情况[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 杨春惠. 耳颞神经在颞颌关节周围的分布[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 王昆润. 牙周炎加重期应选用何种抗生素[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 杨儒壮 孙宏晨 欧阳喈. 纳米级高分子支架材料在组织工程中的研究进展[J]. 国际口腔医学杂志, 2004, 31(02): 126 -128 .
[10] 严超然,李龙江. 肿瘤靶向药物载体系统的研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .