国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (1): 18-22.doi: 10.7518/gjkq.2021016
Qi Xiaoling1,Gan Tingbin2,Huang Jiao1()
摘要:
慢性牙周炎不仅可以导致牙周支持组织的破坏和丧失,还与多种全身系统性疾病如高血压、糖尿病等有关。慢性肾病是一种破坏肾功能的威胁人类健康的常见的全身性疾病。近年来大量研究显示,慢性牙周炎与慢性肾病可能具有相关关系,通过治疗牙周炎有可能改善肾功能。本文就慢性牙周炎与慢性肾病相关性的流行病学调查研究、牙周治疗对慢性肾病的影响以及二者之间相互影响的可能机制进行综述。
中图分类号:
[1] | 孟焕新 . 牙周炎与糖尿病的关系[J]. 北京大学学报(医学版), 2007,39(1):18-20. |
Meng HX . Association between periodontitis and diabetes mellitus[J]. J Peking Univ (Heal Sci), 2007,39(1):18-20. | |
[2] |
Kassebaum NJ, Bernabé E, Dahiya M , et al. Global burden of severe periodontitis in 1990‒2010: a systematic review and meta-regression[J]. J Dent Res, 2014,93(11):1045-1053.
pmid: 25261053 |
[3] | Genco RJ, Borgnakke WS . Risk factors for periodontal disease[J]. Periodontol 2000, 2013,62(1):59-94. |
[4] |
Pradeep AR, Kathariya R, Arjun Raju P , et al. Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case-control study[J]. Int Urol Nephrol, 2012,44(3):829-839.
doi: 10.1007/s11255-011-9997-7 pmid: 21637988 |
[5] | Martin-Cabezas R, Seelam N, Petit C , et al. Association between periodontitis and arterial hypertension: a systematic review and meta-analysis[J]. Am Heart J, 2016,180:98-112. |
[6] |
Wahl P, Ducasa GM, Fornoni A . Systemic and renal lipids in kidney disease development and progression[J]. Am J Physiol Renal Physiol, 2016,310(6):F433-F445.
pmid: 26697982 |
[7] |
Webster AC, Nagler EV, Morton RL , et al. Chronic kidney disease[J]. Lancet, 2017,389(10075):1238-1252.
pmid: 27887750 |
[8] |
Kshirsagar AV, Moss KL, Elter JR , et al. Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study[J]. Am J Kidney Dis, 2005,45(4):650-657.
doi: 10.1053/j.ajkd.2004.12.009 pmid: 15806467 |
[9] | Chang JF, Yeh JC, Chiu YL , et al. Periodontal pocket depth, hyperglycemia, progression of chronic kidney disease: a population-based longitudinal stu-dy[J]. Am J Med, 2017, 130(1): 61-69.e1. |
[10] |
Grubbs V, Vittinghoff E, Taylor G , et al. The association of periodontal disease with kidney function decline: a longitudinal retrospective analysis of the MrOS dental study[J]. Nephrol Dial Transplant, 2016,31(3):466-472.
pmid: 26320037 |
[11] |
Deschamps-Lenhardt S, Martin-Cabezas R, Hann-edouche T, et al. Association between periodontitis and chronic kidney disease: systematic review and meta-analysis[J]. Oral Dis, 2019,25(2):385-402.
pmid: 29377446 |
[12] | Altamimi AG, AlBakr SA, Alanazi TA, et al. Prevalence of periodontitis in patients undergoing hemodialysis: a case control study[J]. Mater Sociomed, 2018,30(1):58-61. |
[13] | Iwasaki M, Taylor GW, Sato M , et al. Cystatin C-based estimated glomerular filtration rate and periodontitis[J]. Gerodontology, 2016,33(3):328-334. |
[14] |
Sharma P, Dietrich T, Sidhu A , et al. The periodontal health component of the Renal Impairment In Secondary Care (RIISC) cohort study: a description of the rationale, methodology and initial baseline results[J]. J Clin Periodontol, 2014,41(7):653-661.
doi: 10.1111/jcpe.12263 |
[15] |
Ausavarungnirun R, Wisetsin S, Rongkiettechakorn N , et al. Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand[J]. BMJ Open, 2016,6(7):e011836.
doi: 10.1136/bmjopen-2016-011836 pmid: 27466240 |
[16] |
Iwasaki M, Taylor GW, Sato M , et al. Effect of chronic kidney disease on progression of clinical attachment loss in older adults: a 4-year cohort study[J]. J Periodontol, 2019,90(8):826-833.
doi: 10.1002/JPER.18-0464 pmid: 30729528 |
[17] |
Almeida S, Figueredo CM, Lemos C , et al. Periodontal treatment in patients with chronic kidney disease: a pilot study[J]. J Periodontal Res, 2017,52(2):262-267.
doi: 10.1111/jre.12390 pmid: 27135778 |
[18] |
Borgnakke WS . Periodontitis may be associated with chronic kidney disease, but current evidence is insufficient[J]. J Evid Based Dent Pract, 2013,13(3):88-90.
pmid: 24011000 |
[19] |
Artese HP, Sousa CO, Luiz RR , et al. Effect of non-surgical periodontal treatment on chronic kidney disease patients[J]. Braz Oral Res, 2010,24(4):449-454.
doi: 10.1590/s1806-83242010000400013 pmid: 21180967 |
[20] |
de Souza CM, Braosi AP, Luczyszyn SM , et al. Association among oral health parameters, periodontitis, and its treatment and mortality in patients undergoing hemodialysis[J]. J Periodontol, 2014,85(6):e169-e178.
doi: 10.1902/jop.2013.130427 pmid: 24224959 |
[21] |
Lee CF, Lin CL, Lin MC , et al. Surgical treatment for patients with periodontal disease reduces risk of end-stage renal disease: a nationwide population-based retrospective cohort study[J]. J Periodontol, 2014,85(1):50-56.
doi: 10.1902/jop.2013.130015 pmid: 23646848 |
[22] |
Fang FC, Wu BL, Qu Q , et al. The clinical response and systemic effects of non-surgical periodontal therapy in end-stage renal disease patients: a 6-month randomized controlled clinical trial[J]. J Clin Periodontol, 2015,42(6):537-546.
doi: 10.1111/jcpe.12411 pmid: 25933364 |
[23] |
Ismail FB, Ismail G, Dumitriu AS , et al. Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study[J]. Biomed Res Int, 2015,2015:370314.
doi: 10.1155/2015/370314 pmid: 25922833 |
[24] |
Olsen I, Hajishengallis G . Major neutrophil functions subverted by Porphyromonas gingivalis[J]. J Oral Microbiol, 2016,8:30936.
doi: 10.3402/jom.v8.30936 pmid: 26993626 |
[25] | Kshirsagar AV, Offenbacher S, Moss KL , et al. Antibodies to periodontal organisms are associated with decreased kidney function. The dental atherosclerosis risk in communities study[J]. Blood Purif, 2007,25(1):125-132. |
[26] |
Akram Z, Abduljabbar T, Abu Hassan MI , et al. Cytokine profile in chronic periodontitis patients with and without obesity: a systematic review and meta-analysis[J]. Dis Markers, 2016,2016:4801418.
doi: 10.1155/2016/4801418 pmid: 27795608 |
[27] |
Sawa Y, Takata S, Hatakeyama Y , et al. Expression of toll-like receptor 2 in glomerular endothelial cells and promotion of diabetic nephropathy by Porphyromonas gingivalis lipopolysaccharide[J]. PLoS One, 2014,9(5):e97165.
doi: 10.1371/journal.pone.0097165 pmid: 24835775 |
[28] |
Zhang BX, Khalaf H, Sirsjö A , et al. Gingipains from the periodontal pathogen Porphyromonas gingivalis play a significant role in regulation of angiopoietin 1 and angiopoietin 2 in human aortic smooth muscle cells[J]. Infect Immun, 2015,83(11):4256-4265.
doi: 10.1128/IAI.00498-15 pmid: 26283334 |
[29] |
Santos CF, Morandini AC, Dionísio TJ , et al. Functional local renin-angiotensin system in human and rat periodontal tissue[J]. PLoS One, 2015,10(8):e0134601.
doi: 10.1371/journal.pone.0134601 pmid: 26244896 |
[30] |
Ariyamuthu VK, Nolph KD, Ringdahl BE . Periodontal disease in chronic kidney disease and end-stage renal disease patients: a review[J]. Cardiorenal Med, 2013,3(1):71-78.
doi: 10.1159/000350046 pmid: 23802000 |
[31] | Lacson E, Levin NW . Poor nutritional status and inflammation: C‐reactive protein and end‐stage renal disease[J]. Semin Dialys, 2004,17(6):438-448. |
[32] | Chopra A, Sivaraman K . An update on possible pathogenic mechanisms of periodontal pathogens on renal dysfunction[J]. Crit Rev Microbiol, 2019,45(5/6):514-538. |
[33] |
Stasi A, Intini A, Divella C , et al. Emerging role of lipopolysaccharide binding protein in sepsis-induced acute kidney injury[J]. Nephrol Dial Transplant, 2017,32(1):24-31.
doi: 10.1093/ndt/gfw250 pmid: 27387474 |
[34] | Tomofuji T, Ekuni D, Irie K , et al. Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats[J]. Bio-med Res, 2011,32(5):343-349. |
[35] |
Grauballe MB, Østergaard JA, Schou S , et al. Effects of TNF-α blocking on experimental periodontitis and type 2 diabetes in obese diabetic Zucker rats[J]. J Clin Periodontol, 2015,42(9):807-816.
doi: 10.1111/jcpe.12442 pmid: 26257165 |
[36] |
Navarro JF, Mora C, Maca M , et al. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus[J]. Am J Kidney Dis, 2003,42(1):53-61.
doi: 10.1016/s0272-6386(03)00408-6 pmid: 12830456 |
[37] | Armingohar Z, Jørgensen JJ, Kristoffersen AK , et al. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis[J]. J Oral Microbiol, 2014,6(1):23408. |
[38] | Nunes CMM, Ferreira CL, Bernardo DV , et al. Chr-onic kidney disease and periodontal disease. Case report[J]. Braz Dent Sci, 2018,21(1):133-143. |
[39] | Kapellas K, Singh A, Bertotti M , et al. Periodontal and chronic kidney disease association: a systematic review and meta-analysis[J]. Nephrology (Carlton), 2019,24(2):202-212. |
[1] | 范琳,孙江. 微针在口腔医学中的应用[J]. 国际口腔医学杂志, 2023, 50(4): 472-478. |
[2] | 施培磊,于晨浩,谢旭东,吴亚菲,王骏. 牙源性间充质干细胞应用于牙周组织缺损修复的研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 690-695. |
[3] | 原振英,管翠强,南欣荣. DNA甲基化与口腔疾病的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 437-441. |
[4] | 贾婷婷,颜世果. 特异性AT序列结合蛋白2在颌面部发育及牙周组织再生中作用的研究进展[J]. 国际口腔医学杂志, 2019, 46(3): 320-325. |
[5] | 董正谋,刘锐,刘鲁川,温秀杰. 种子细胞在牙周组织再生治疗中的研究进展[J]. 国际口腔医学杂志, 2019, 46(1): 48-54. |
[6] | 王静,王艳,王川东,黄睿洁,田燕,胡玮,邹静. 甘草及其提取物在防治口腔感染相关疾病中的应用[J]. 国际口腔医学杂志, 2018, 45(5): 546-552. |
[7] | 黄海霞, 兰玉燕, 张昊, 潘兰兰, 郭玲, 刘敏. 慢性牙周炎患者种植修复后种植体牙周指数及龈沟液炎性因子水平的变化研究[J]. 国际口腔医学杂志, 2018, 45(4): 396-402. |
[8] | 李琳, 王丹, 赵曼竹, 唐明. 慢性牙周炎与神经退行性疾病相关性的研究进展[J]. 国际口腔医学杂志, 2017, 44(5): 514-518. |
[9] | 杨春艳, 税艳青. 单核苷酸多态性与慢性牙周炎相关关系的研究进展[J]. 国际口腔医学杂志, 2017, 44(4): 452-458. |
[10] | 安宁, 唐正龙. 甲状旁腺激素调控牙周组织改建的研究进展[J]. 国际口腔医学杂志, 2017, 44(4): 466-470. |
[11] | 赵红, 王新林, 吕治, 王冬青, 苏建荣. 基于高通量测序技术研究慢性牙周炎患者龈下刮治和根面平整术治疗前后龈下菌群的变化[J]. 国际口腔医学杂志, 2017, 44(3): 294-300. |
[12] | 杨洋, 徐燕. 牙囊细胞及其在牙周组织再生中的应用[J]. 国际口腔医学杂志, 2017, 44(3): 332-335. |
[13] | 姜雨汐, 刘树泰. 牙周韧带细胞膜片技术用于牙周组织再生的研究进展[J]. 国际口腔医学杂志, 2017, 44(2): 204-208. |
[14] | 李紫嫣,李鑫,周进茹,李磊. 低强度脉冲超声在牙周组织再生中的作用[J]. 国际口腔医学杂志, 2016, 43(3): 329-332. |
[15] | 刘琼,谢昊,孙江. 超声系统治疗与牙周翻瓣术的短期疗效比较[J]. 国际口腔医学杂志, 2016, 43(2): 159-164. |
|