国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (1): 108-113.doi: 10.7518/gjkq.2017.01.022

• ·综述· • 上一篇    下一篇

微小RNA在骨分化过程中的作用机制

刘润恒,刘于冬,陈卓凡   

  1. 中山大学光华口腔医学院•附属口腔医院种植科广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2016-02-11 出版日期:2017-01-01 发布日期:2017-01-01
  • 通讯作者: 陈卓凡,教授,博士,Email：dentistczf@163.com
  • 作者简介:刘润恒,博士,Email：1207736451@qq.com
  • 基金资助:
    国家自然科学基金（81470783）

Role and mechanism of microRNA in osteogenic differentiation

Liu Runheng, Liu Yudong, Chen Zhuofan.   

  1. Dept. of Implantation, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2016-02-11 Online:2017-01-01 Published:2017-01-01

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摘要： 在口腔种植治疗过程中常常会遇到骨量不足的问题,植入骨替代材料是目前临床上最主要的重建骨缺损方法之一,因此骨替代材料的成骨性能及其分子机制成为了研究热点。微小RNA（miRNA）是一种短链非编码RNA,通过转录后调控细胞分化、增殖、程序性死亡等病理生理过程。miRNA可影响成骨相关因子的表达和激活成骨相关信号转导通路中的信号转导,从而对骨组织动态改建过程进行调控。本文就miRNA与成骨细胞特异性转录因子、核心结合因子-α1基因、Smad基因、转化生长因子-β诱导因子,与骨形态发生蛋白信号转导通路、无翅型小鼠乳房肿瘤病毒整合位点家族信号转导通路、促丝裂原激活蛋白激酶信号转导通路、成脂信号转导通路以及miRNA与口腔相关材料和miRNA在骨缺损修复中的应用研究进展作一综述。

关键词: 微小RNA, 骨分化, 骨分化调节因子, 信号转导通路

Abstract: The problem of insufficient bone usually occurs during oral implantology treatment. The use of bone substitute materials is one of the most important methods to reconstruct bone defects clinically. Therefore, the properties and molecular mechanisms of these bone substitute materials have been a controversial topic in research. MicroRNA(miRNA) is a short, non-coding RNA. It regulates cell differentiation, proliferation, apoptosis, and other pathophysiological processes by post-transcription. In addition, miRNA can regulate the dynamic remodeling of bone tissue by affecting the expression of osteogenic factors and the activation of osteogenic signal transduction pathway. This paper reviews the role of miRNA in osterix, core binding factor α1, Smad, and transforming growth factor-β. The regulating function of miRNA in the signal transduction pathways of bone morphogenetic protein, wingless-type mice mammary tumor virus integration site family, mitogen-activated protein kinase, and adipogenesis is investigated. The relation of miRNA with dental materials and its application in repairing bone defects are also reviewed.

Key words: microRNA, osteogenic differentiation, regulatory factor of osteogenic differentiation, signal transduction pathway

中图分类号: 

  • Q786
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