Int J Stomatol ›› 2025, Vol. 52 ›› Issue (1): 34-41.doi: 10.7518/gjkq.2025007

• Oral Oncology • Previous Articles     Next Articles

Progress in research on phosphoinositide 3-kinase/protein kinase B pathway inhibitors in oral squamous cell carcinoma

Jingzhe Li(),Suxin Zhang()   

  1. Dept. of Oral and Maxillofacial Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2024-02-17 Revised:2024-08-02 Online:2025-01-01 Published:2025-01-11
  • Contact: Suxin Zhang E-mail:1048336251@qq.com;jasmine@hebmu.edu.cn
  • Supported by:
    Hebei Provincial Department of Finance Elderly Disease Prevention and Control Project(13000022-P00860410186E);Key Science and Technology Research Program of Hebei Provincial Health Commission(20190695)

Abstract:

Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial tumor with a high incidence rate and is a serious threat to human health. The phosphoinositide 3-kinase/protein kinase B pathway affects disease progression in va-rious cancer types. Given that this pathway is frequently activated in OSCC, it is a candidate pathway for therapeutic interventions for OSCC. Thus, inhibitors targeting this pathway are currently being developed. This article focuses on current progress in research on this pathway and discusses the recent status of research on drugs targeting it.

Key words: phosphoinositide 3-kinase, protein kinase B, inhibitors, oral squamous cell carcinoma

CLC Number: 

  • Q257

TrendMD: 

Fig 1

PI3K/AKT signaling pathway"

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