Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (3): 329-334.doi: 10.7518/gjkq.2023030

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Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia

Sun Jia1(),Han Ye2,Hou Jianxia2()   

  1. 1.Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
    2.Dept. of Periodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Cli-nical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China
  • Received:2022-10-05 Revised:2023-01-02 Online:2023-05-01 Published:2023-05-16
  • Contact: Jianxia Hou E-mail:kqyyyzsj@163.com;jxhou@163.com
  • Supported by:
    National Natural Science Foundation of China(82071117);Natural Science Foundation of Beijing(7212136);Health Science and Technology Project of Tianjin(TJWJ2022QN073)

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Abstract:

Periodontitis is a chronic inflammatory disease initiated by bacterial infection. The pathogenic micro-organisms and their toxic products activate the host defense system and evoke immune-inflammatory responses, which affect systemic health. Periodontitis is a risk factor for many systemic diseases. Anemia of inflammation (AI), the second most prevalent type of anemia, occurs in chronic or acute infections and manifests as infection, inflammation, or tumor. These diseases activate the host defense system, resulting in systemic iron disorder and iron-restricted hemoglobin production disorders. A close association exists between AI and periodontitis, but the potential mechanism remains unclear. The interleukin-6-hepcidin signal axis is suggested to play a central role. This paper discusses the recent findings of the asso-ciation between AI and periodontitis to provide theoretical basis and clinical guidance for the prevention, diagnosis, and treatment of periodontitis-associated AI.

Key words: periodontitis, anemia of inflammation, iron metabolism, hepcidin, interleukin-6

CLC Number: 

  • R 781.4

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