Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (4): 450-455.doi: 10.7518/gjkq.2019031

• Reviews • Previous Articles     Next Articles

Review of NLRP3 inflammasomes in periodontal diseases

Zhu Bowen1,Chen Limei1,Guo Zhuling1,2()   

  1. 1. School of Stomatology, Hainan Medical University, Haikou 570100, China
    2. Dept. of Stomatology, The First Affiliated Hospital of Hainan Medical University, Haikou 570100, China
  • Received:2018-04-08 Revised:2019-01-02 Online:2019-07-01 Published:2019-07-12
  • Supported by:
    This study was supported by Hainan Provincial Natural Science Foundation(817330);Scientific Research Projects of Higher Education Institutions in Hainan Province(Hnky2017-31);Young Talents’ Science and Technology Innovation Project of Hainan Association for Science and Technology(QCXM201817);Youth Development Fund Project of the First Affiliated Hospital of Hainan Medical University(HYFYPY201702);Course Construction Project of Hainan Medical University(HYJW201834)

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Abstract:

Periodontal disease is considered as the joint effort of microbial infection and immunoinflammatory responses. The association between NLRP3 inflammasome and periodontal disease has been confirmed in many experiments. The reverse states, activation and inhibition of NLRP3 inflammasome have received increasing attention. In the progress of periodontal disease, the explanations for the activation and inhibition of the NLRP3 inflammasome have not been unified with the triggering conditions and the switching process. Studies on NLRP3 inflammasome gene mutation or gene polymorphism in periodontal disease have just been initiated. This article briefly describes the NLRP3 inflammasome and highlights the currently accepted hypothesis of the activation of this oligomer and the finding regarding various inhibitory mechanisms.

Key words: NLRP3, inflammasome, periodontal disease, immunoinflammatory responses

CLC Number: 

  • R781.4

TrendMD: 

Fig 1

Composition and assembly of NLRP3 inflammasome"

Fig 2

Signaling models of NLRP3 inflammasome"

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