Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (4): 466-470.doi: 10.7518/gjkq.2017.04.019

• Reviews • Previous Articles     Next Articles

Research progress on the regulation of parathyroid hormone on the remodeling of periodontal tissues

An Ning, Tang Zhenglong   

  1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
  • Received:2016-08-22 Revised:2017-02-13 Online:2017-07-01 Published:2017-07-01
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81460101).

Abstract: Parathyroid hormone(PTH) is a polypeptide molecule synthesized and secreted by the chief cell of parathyroid glands and is a vital calcium-regulating hormone, which could maintain the balance of calcium and phosphorus metabolism in vivo. PTH could promote the regeneration and absorption of bone and accelerate bone turnover. Nowadays, PTH is used for the prevention and treatment of osteoporosis in menstruating women and could decrease the rate of fracture in clinic. Moreover, researchers found that PTH could promote the concrescence and remodeling of periodontal tissue, control the absorption of alveolar bone, accelerate orthodontic tooth movement, and improve the osseointegration of dental implant by stimulating the proliferation and differentiation of osteoblast, osteoclast, periodontal ligament cell, and cementoblast. This review focuses on the progress of PTH in the regeneration and remodeling of periodontal tissue in recent years.

Key words: parathyroid hormone, periodontal tissue, bone regeneration, alveolar bone

CLC Number: 

  • Q813

TrendMD: 
[1] Mansjur KQ, Kuroda S, Izawa T, et al. The effec-tiveness of human parathyroid hormone and low-intensity pulsed ultrasound on the fracture healing in osteoporotic bones[J]. Ann Biomed Eng, 2016, 44 (8):2480-2488.
[2] Aggarwal P, Zavras A. Parathyroid hormone and its effects on dental tissues[J]. Oral Dis, 2012, 18(1):48- 54.
[3] Tang ZL, Zhang WJ, Wang DX, et al. An experimental study addressing the promotion of mandibular defect repair through the intermittent subcutaneous injec-tion of parathyroid hormone[J]. J Oral Maxillofac Surg, 2014, 72(2):419-430.
[4] Tang ZL, Bai S, Zhu PN, et al. An examination of differences in the new bone formation promoted by different doses of recombinant human parathyroid hormone during mandibular distraction osteogenesis [J]. Plast Reconstr Surg, 2016, 137(2):347e-354e.
[5] Tanaka S, Hata K, Yoneda T. Potential use of parathyroid hormone(PTH) in the treatments for oral diseases[J]. Clin Calcium, 2012, 22(1):75-82.
[6] Vasconcelos DF, Vasconcelos AC. PTH intermittent administration may be a useful therapeutic agent to avoid premature eruption of the tooth[J]. Med Hypo-theses, 2016, 88:27-29.
[7] Almagro MI, Roman-Blas JA, Bellido M, et al. PTH [1-34] enhances bone response around Titanium implants in a rabbit model of osteoporosis[J]. Clin Oral Implants Res, 2013, 24(9):1027-1034.
[8] Tokunaga K, Seto H, Ohba H, et al. Topical and intermittent application of parathyroid hormone re-covers alveolar bone loss in rat experimental perio-dontitis[J]. J Periodontal Res, 2011, 46(6):655-662.
[9] Bashutski JD, Eber RM, Kinney JS, et al. Teri-paratide and osseous regeneration in the oral cavity [J]. N Engl J Med, 2010, 363(25):2396-2405.
[10] Barros SP, Silva MA, Somerman MJ, et al. Para-thyroid hormone protects against periodontitis-associated bone loss[J]. J Dent Res, 2003, 82(10): 791-795.
[11] Cheung A, Seeman E. Teriparatide therapy for alendronate-associated osteonecrosis of the jaw[J]. N Engl J Med, 2010, 363(25):2473-2474.
[12] Hata K. Clinical and preclinical application of PTH and BMP to dental treatment[J]. Clin Calcium, 2016, 26(3):466-474.
[13] Wang X, Wang Y, Dai X,et al. Effects of inter-mittent administration of parathyroid hormone(1-34) on bone differentiation in stromal precursor an-tigen-1 positive human periodontal ligament stem cells[J]. Stem Cells Int, 2016, 2016:4027542.
[14] Vasconcelos DF, Marques MR, Benatti BB, et al. Intermittent parathyroid hormone administration improves periodontal healing in rats[J]. J Periodon-tol, 2014, 85(5):721-728.
[15] Otawa M, Tanoue R, Kido H, et al. Intermittent administration of parathyroid hormone ameliorates periapical lesions in mice[J]. J Endod, 2015, 41(5): 646-651.
[16] Kuroshima S, Kovacic BL, Kozloff KM, et al. Intra-oral PTH administration promotes tooth extraction socket healing[J]. J Dent Res, 2013, 92(6):553-559.
[17] Beppu K, Kido H, Watazu A, et al. Peri-implant bone density in senile osteoporosis-changes from implant placement to osseointegration[J]. Clin Implant Dent Relat Res, 2013, 15(2):217-226.
[18] Marques MR, Da Silva MA, Manzi FR, et al. Effect of intermittent PTH administration in the perio-dontitis-associated bone loss in ovariectomized rats [J]. Arch Oral Biol, 2005, 50(4):421-429.
[19] Takedachi M, Murakami S. Present status of perio-dontal regeneration—FGF-2 and Teriparatide[J]. Clin Calcium, 2012, 22(1):99-104.
[20] Monnouchi S, Maeda H, Yuda A, et al. Mechanical induction of interleukin-11 regulates osteoblastic/cementoblastic differentiation of human periodontal ligament stem/progenitor cells[J]. J Periodontal Res, 2015, 50(2):231-239.
[21] Wolf M, Jäger A, Abuduwali N, et al. Continuous PTH modulates alkaline phosphatase activity in human PDL cells via protein kinase C dependent pathways in vitro [J]. Ann Anat, 2013, 195(5):455- 460.
[22] Wolf M, Lossdörfer S, Abuduwali N, et al. Effect of intermittent PTH(1-34) on human periodontal liga-ment cells transplanted into immunocompromised mice[J]. Tissue Eng Part A, 2012, 18(17/18):1849- 1856.
[23] Wolf M, Lossdörfer S, Abuduwali N, et al. Potential role of high mobility group box protein 1 and intermittent PTH(1-34) in periodontal tissue repair following orthodontic tooth movement in rats[J]. Clin Oral Investig, 2013, 17(3):989-997.
[24] Jin SH, Lee JE, Yun JH, et al. Isolation and charac-terization of human mesenchymal stem cells from gingival connective tissue[J]. J Periodontal Res, 2015, 50(4):461-467.
[25] Ren YJ, Maltha JC, Kuijpers-Jagtman AM. Optimum force magnitude for orthodontic tooth movement: a systematic literature review[J]. Angle Orthod, 2003, 73(1):86-92.
[26] Lossdörfer S, Yildiz F, Götz W, et al. Anabolic effect of intermittent PTH(1-34) on the local microenviron-ment during the late phase of periodontal repair in a rat model of tooth root resorption[J]. Clin Oral In-vestig, 2010, 14(1):89-98.
[27] Wang L, Tran AB, Nociti FH, et al. PTH and vitamin D repress DMP1 in cementoblasts[J]. J Dent Res, 2015, 94(10):1408-1416.
[28] Soma S, Iwamoto M, Higuchi Y, et al. Effects of continuous infusion of PTH on experimental tooth movement in rats[J]. J Bone Miner Res, 1999, 14(4): 546-554.
[29] Soma S, Matsumoto S, Higuchi Y, et al. Local and chronic application of PTH accelerates tooth move-ment in rats[J]. J Dent Res, 2000, 79(9):1717-1724.
[30] Salazar M, Hernandes L, Ramos AL, et al. Effect of teriparatide on induced tooth displacement in ovariec-tomized rats: a histomorphometric analysis[J]. Am J Orthod Dentofacial Orthop, 2011, 139(4):e337-e344.
[31] Li F, Li G, Hu H, et al. Effect of parathyroid hor-mone on experimental tooth movement in rats[J]. Am J Orthod Dentofacial Orthop, 2013, 144(4):523- 532.
[32] Stanford CM, Schneider GB. Functional behaviour of bone around dental implants[J]. Gerodontology, 2004, 21(2):71-77.
[33] Skripitz R, Johansson HR, Ulrich SD, et al. Effect of alendronate and intermittent parathyroid hormone on implant fixation in ovariectomized rats[J]. J Orthop Sci, 2009, 14(2):138-143.
[34] Bellido M, Lugo L, Castañeda S, et al. PTH in-creases jaw mineral density in a rabbit model of osteoporosis[J]. J Dent Res, 2010, 89(4):360-365.
[35] Heo HA, Park SH, Jeon YS, et al. Enhancing effect of intermittent parathyroid hormone administration on bone formation after Titanium implant placement in an ovariectomized rat maxilla[J]. Implant Dent, 2016, 25(2):227-231.
[36] Lima LL, César Neto JB, Cayana EG, et al. Para-thyroid hormone(1-34) compensates the negative effect of smoking around implants[J]. Clin Oral Im-plants Res, 2013, 24(9):1055-1059.
[37] Zeng X, He H, Zhang L, et al. A potential therapeutic approach to overload-induced bone loss around implant: parathyroid hormone(PTH)[J]. Med Hypo-theses, 2011, 77(5):701-704.
[1] Chang Xinnan,Liu Lei. Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery [J]. Int J Stomatol, 2024, 51(1): 107-115.
[2] Yu Yuelin,Kong Weidong. Research progress on the association between primary failure of tooth eruption and parathyroid hormone receptor 1 gene [J]. Int J Stomatol, 2023, 50(5): 573-580.
[3] Fan Lin,Sun Jiang.. Application of microneedles in stomatology [J]. Int J Stomatol, 2023, 50(4): 472-478.
[4] Xu Yanxue,Fu Li.. Research progress on functionally graded membranes for guided bone regeneration [J]. Int J Stomatol, 2023, 50(3): 353-358.
[5] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontics microsurgery: clinical protocol and practical cases (part 2) [J]. Int J Stomatol, 2022, 49(6): 621-632.
[6] Yin Yijia,Yang Jinting,Shen Jianqi,Huang Lingyi,Jing Yan,Guan Qiuyue,Han Xianglong. Endothelial-cell-specific overexpression of Dickkopf 1 using Cadherin 5 promoter regulates osteogenesis in vivo [J]. Int J Stomatol, 2022, 49(6): 641-647.
[7] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[8] Cai Chaoying,Chen Xuepeng,Hu Ji’an. Research progress on exosome composite scaffolds in oral tissue engineering [J]. Int J Stomatol, 2022, 49(4): 489-496.
[9] Li Yanfei,Zhang Xinchun. Research progress on the dentin bone repair material [J]. Int J Stomatol, 2022, 49(2): 197-203.
[10] Jiang Duan,Shen Daonan,Zhao Lei,Wu Yafei. Research progress on the relationship between new anti-inflammatory factor developmental endothelial locus-1 and periodontitis [J]. Int J Stomatol, 2022, 49(2): 244-248.
[11] Shi Peilei,Yu Chenhao,Xie Xudong,Wu Yafei,Wang Jun. Research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair [J]. Int J Stomatol, 2021, 48(6): 690-695.
[12] Li Yuan-yuan,Chen Junyu,Cai He,Wan Qianbing. Effects of parathyroid hormone and parathyroid hormone-related peptide on hard dental tissue formation [J]. Int J Stomatol, 2021, 48(6): 703-710.
[13] Xu Lin,Wang Ruyi,Gou Xinrui,Wang Xiaoli,Li Yu. Research progress on parathyroid hormone-related protein modulating mandibular condylar cartilage [J]. Int J Stomatol, 2021, 48(5): 549-555.
[14] Liu Jiacheng,Meng Zhaosong,Li Hongjie,Sui Lei. The role of follistatin in oral and maxillofacial development and its therapeutic application prospect [J]. Int J Stomatol, 2021, 48(5): 556-562.
[15] Zhao Wenjun,Chen Yu. Research progress on periodontal functional gradient membrane for guided tissue/bone regeneration [J]. Int J Stomatol, 2021, 48(4): 391-397.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .