Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 113-116.doi: 10.3969/j.issn.1673-5749.2012.01.031

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Clinical manifestation and treatment of graft versus host disease in oral cavity

Wang Wei, Yao Hua.   

  1. Dept. of Stomatology, The Affiliated First Hospital of Medical College, Zhejiang University, Hangzhou 310003, China
  • Received:2010-08-27 Revised:2011-07-18 Online:2012-01-01 Published:2012-01-01

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Abstract:

Allogenic hematopoietic stem cell transplantation（HSCT） is the most effective treatment for malignant hematologic disease, while graft versus host disease（GVHD） is the main complication and leading cause of mortality in patients receiving HSCT. Oral cavity involvement occurs frequently in patients suffering from GVHD, and it may be the primary or even the only site of GVHD. It is essential for oral professionals to be familiar with various oral GVHD. This review discusses the pathogenesis, multifarious clinical manifestation, available evidence for diagnostic, and the progress of treatment in oral GVHD. The management of the oral GVHD seems to be important in the early diagnosis of GVHD.

Key words: graft versus host disease, oral manifestation, treatment, malignant hematologic disease


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