Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (4): 467-474.doi: 10.7518/gjkq.2024064

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Effects and mechanism of exosomes derived from dental mesenchymal stem cells on dental pulp regeneration

Hui Lu(),Yexin Zheng,Wei Zhao()   

  1. Dept. of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, ChinaSupported byFoundation:Natural Science Foundation of Guangdong Province (2023A1515012554 )
  • Received:2023-10-26 Revised:2024-02-26 Online:2024-07-01 Published:2024-06-24
  • Contact: Wei Zhao E-mail:luhui7@mail2.sysu.edu.cn;zhaowei3@mail.sysu.edu.cn

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Abstract:

Pulp regeneration is a new strategy for pulp necrosis treatment based on tissue engineering. Seed cells combined with scaffolds and growth factors are used to regenerate dentin, blood vessels, and nerves. As extracellular vesicles with a diameter of approximately 30~150 nm, exosomes play an important role in the transmission of regulatory information between cells. In recent years, exosomes derived from dental mesenchymal stem cells have attracted attention because of their great potential in pulp regeneration. In this article, the species and culture environment of exosomes derived from dental mesenchymal stem cells were introduced. The effect and mechanism of exosomes derived from dental mesenchymal stem cells in regulating odontogenic differentiation, angiogenesis, nerve regeneration, and osteoblastic differentiation were also reviewed.

Key words: exosome, pulp regeneration, dental mesenchymal stem cells

CLC Number: 

  • R781.3

TrendMD: 

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