Int J Stomatol ›› 2021, Vol. 48 ›› Issue (4): 450-458.doi: 10.7518/gjkq.2021065

• Reviews • Previous Articles     Next Articles

Unique biological behavior and treatment of the human papilloma virus 16-related oropharyngeal squamous cell carcinoma

Wang Yue1,2(),Ji Yiming1,2,Wang Xiaoyi3,Zhang Lingnan4,Sun Legang1,2()   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
    2. School of Stomatology, Binzhou Medical University, Yantai 264010, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. Dept. of Orthodontics, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
  • Received:2020-11-22 Revised:2021-03-20 Online:2021-07-01 Published:2021-06-30
  • Contact: Legang Sun;
  • Supported by:
    Natural Science Foundation of Shandong Province(ZR2018BH026);Development Plan of Medical and Health Science and Technology in Shandong Province(2017WS231);Binzhou Social Science Planning Key Research Project(19-SKGH-31)


Human papilloma virus (HPV) infection is the third-largest independent etiological factor causing orophar-yngeal squamous cell carcinoma (OPSCC) apart from smoking and drinking. High-risk HPV16 plays an important role in the occurrence and development of OPSCC. Considering its unique clinicopathologic features, the prognosis and treatment methods for HPV16-related OPSCC are significantly different from those for traditional OPSCC. Based on the original treatment methods, transoral endoscopic surgery, radiochemotherapy, immunotherapy, and vaccine treatment are extended. This paper focuses on the unique clinicopathologic features and treatment methods of HPV16-related OPSCC.

Key words: human papilloma virus, oropharyngeal squamous cell carcinoma, unique clinicopathologic features, treatment

CLC Number: 

  • R739.8


Fig 1

Mechanism of HPV16 carcinogenesis"

Tab 1

Clinicopathological characteristics of HPV16 in different infection states"

临床病理特征 HPV16相关OPSCC 传统OPSCC
发病率 增加 减少
病因 吸烟、饮酒、HPV感染 吸烟、饮酒
发病年龄 年轻化 可发于任何年龄,中老年多见
发病部位 扁桃体、舌根部 口咽部任何部位,甚至波及其他部位
症状 无明显疼痛、仅出现颈部的囊性肿大 咽喉部疼痛、吞咽异物感
淋巴结转移 早期可出现转移 任何时期均可能转移
预后 较好
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