Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (5): 548-552.doi: 10.7518/gjkq.2015.05.015

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Expressions of S100A7 in oral submucous fibrosis before and after treatment

Song Xuelong1, Wei Gaoxing1, Wu Yingfang1, Peng Jieying1, Liu Gengxun2.   

  1. 1. Dept. of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China; 2. Dept. of Pathology, No.163 Hospital of PLA, Changsha 410003, China
  • Received:2015-02-17 Revised:2015-06-14 Online:2015-09-01 Published:2015-09-01

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Abstract:

Objective To check the expressions of S100A7 in the buccal mucosa of oral submucous fibrosis(OSF) patients before and after treatment and normal buccal mucosa. Methods Buccal mucosa specimens of 10 normal people and 10 OSF patients (before and after treatment by local injections of triamcinolone acetonide acetate and salvia miltiorrhiza) are collected, their expressions of S100A7 checked by immunohistochemistry and the data analyzed statistically. Results 1) After the treatment, S100A7 positive rate of patients with OSF was 30%, expression of scoring is (2.30±0.82) points, are lower than before treatment amount of positive rate(90%) and express the scoring value(4.20±1.14), and the difference was statistically significant(P<0.05). 2) S100A7 positive rate of OSF patients after the treatment, and normal mucosa were 30%, 0, respectively, there was no statistically significant difference(P>0.05); but the expression of S100A7 with OSF after treatment score values(2.30±0.82), is higher than that of normal mucosa express quantity scoring (0.60±0.52), the difference was statistically significant(P<0.05). Conclusion Treatment can downregulate S100A7 expression, suggesting a promising biomarker to evaluate OSF prognosis.

Key words: treatment, immunohistochemistry, S100A7, oral submucous fibrosis


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