Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (3): 324-327.doi: 10.3969/j.issn.1673-5749.2012.03.012

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Antimicrobial peptide LL-37 and its relationship between periodontal disease

Su Ruiying1，2, Chen Shanshan1，2, Zhao Lei2.   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2011-01-07 Revised:2012-02-03 Online:2012-05-01 Published:2012-05-01

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Abstract:

Periodontal disease is a chronic inflammatory disease that leads to destruction of the periodontium. The abnormal innate immune defense and outcome of periodontal disease is closely related. Cathelicidin is one of endogenous peptide, hCAP-18 and LL-37 is the only member of the cathelicidin family known to exist in human. The former is regarded as an inactive precursor, and the latter is the active mature form. In this review, we emphasize on the hCAP-18, the function of LL-37 and its relationship between periodontal disease.

Key words: LL-37, antimicrobial peptide, cathelicidin, periodontal disease, innate immunity


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