国际口腔医学杂志 ›› 2013, Vol. 40 ›› Issue (1): 72-75.doi: 10.7518/gjkq.2013.01.019
桑磊1,2 李宏卫2,3
Sang Lei 1,2 , Li Hongwei 2,3.
摘要:
整联蛋白(INT)-αvβ6是一类特殊的INT-亚型, 在上皮源性恶性肿瘤组织和创伤愈合组织中高表达,在健康组织和良性肿瘤组织中不表达。INT-αvβ6通过促进肿瘤细胞的迁移、参与细胞外基质降解、激活转化生长因子-β1和抑制肿瘤程序性细胞死亡等途径促进肿瘤的侵袭和转移。本文就INT-αvβ6、INT-αvβ6的信号传导、INT-αvβ6与口腔鳞状细胞癌和INT-αvβ6与肿瘤预后等研究进展作一综述。
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