国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (4): 488-492.doi: 10.7518/gjkq.2017.04.023
伍彩娟, 杨岚, 郭吕华
Wu Caijuan, Yang Lan, Guo Lühua
摘要: 骨量不足是目前口腔种植修复中经常面临的问题,常用的骨组织再生办法有很多,如自体骨移植、生物骨粉及富血小板纤维膜的利用等,但临床效果都不是很显著。骨是一种由破骨和成骨细胞介导的处于动态代谢更新状态的组织,骨代谢受各种全身因素的影响,降钙素基因相关肽(CGRP)是一种在人体广泛分布的神经肽,多项研究表明其在骨代谢中具有重要作用,特别是在成骨方面。其具体成骨作用及机制尚未完全清楚,一直在探讨之中,本文对此作一综述。
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[1] Lv S, Liu H, Cui J, et al. Histochemical examination of cathepsin K, MMP1 and MMP2 in compressed periodontal ligament during orthodontic tooth move-ment in periostin deficient mice[J]. J Mol Histol, 2014, 45(3):303-309. [2] Dimitriou R, Jones E, McGonagle D, et al. Bone regeneration: current concepts and future directions [J]. BMC Med, 2011, 9:66. [3] Giannoudis PV, Einhorn TA. Bone morphogenetic proteins in musculoskeletal medicine[J]. Injury, 2009, 40(Suppl 3):S1-S3. [4] Ivanovski S, Vaquette C, Gronthos S, et al. Multi-phasic scaffolds for periodontal tissue engineering [J]. J Dent Res, 2014, 93(12):1212-1221. [5] Magan A, Ripamonti U. Biological aspects of perio-dontal tissue regeneration: cementogenesis and the induction of Sharpey’s fibres[J]. SADJ, 2013, 68(7): 304-306, 308-312, 314. [6] Sun J, Zhang T, Zhang P, et al. Overexpression of the PLAP-1 gene inhibits the differentiation of BMSCs into osteoblast-like cells[J]. J Mol Histol, 2014, 45(5):599-608. [7] 郑林丰, 谢应桂, 许愿忠. 降钙素基因相关肽在神经系统损伤中的作用[J]. 创伤外科杂志, 2006, 8 (6):571-573. Zheng LF, Xie YG, Xu YZ. Effects of calcitonin gene-related peptide on nerve system injury[J]. J Traumat Surg, 2006, 8(6):571-573. [8] Martin CD, Jimenez-Andrade JM, Ghilardi JR, et al. Organization of a unique net-like meshwork of CGRP + sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain[J]. Neurosci Lett, 2007, 427(3): 148-152. [9] Wang L, Shi X, Zhao R, et al. Calcitonin-gene-rela-ted peptide stimulates stromal cell osteogenic diffe-rentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption[J]. Bone, 2010, 46(5):1369-1379. [10] Lv L, Wang Y, Zhang J, et al. Healing of periodontal defects and calcitonin gene related peptide expre-ssion following inferior alveolar nerve transection in rats[J]. J Mol Histol, 2014, 45(3):311-320. [11] Lv S, Li J, Feng W, et al. Expression of HMGB1 in the periodontal tissue subjected to orthodontic force application by Waldo’s method in mice[J]. J Mol Histol, 2015, 46(1):107-114. [12] Li J, Kreicbergs A, Bergström J, et al. Site-specific CGRP innervation coincides with bone formation during fracture healing and modeling: A study in rat angulated tibia[J]. J Orthop Res, 2007, 25(9):1204- 1212. [13] Wu Y, Jing D, Ouyang H, et al. Pre-implanted sensory nerve could enhance the neurotization in tissue-engineered bone graft[J]. Tissue Eng Part A, 2015, 21(15/16):2241-2249. [14] Sample SJ, Hao Z, Wilson AP, et al. Role of calci-tonin gene-related peptide in bone repair after cyclic fatigue loading[J]. PLoS One, 2011, 6(6):e20386. [15] 马文辉, 时述山, 李亚非, 等. 神经肽对人成骨细胞生物学影响机理的研究[J]. 中国矫形外科杂志, 2001, 8(11):1091-1095. Ma WH, Shi SS, Li YF, et al. Mechanism of the effects of neuropeptides to the main biological action of normal osteoblnst of people[J]. Orthop J Chin, 2001, 8(11):1091-1095. [16] Lerner UH. Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone[J]. J Musculoskelet Neuronal In-teract, 2006, 6(1):87-95. [17] Ma W, Zhang X, Shi S, et al. Neuropeptides stimu-late human osteoblast activity and promote gap junc-tional intercellular communication[J]. Neurope-ptides, 2013, 47(3):179-186. [18] Qi T, Hay DL. Structure-function relationships of the N-terminus of receptor activity-modifying pro-teins[J]. Br J Pharmacol, 2010, 159(5):1059-1068. [19] Zhang Z, Dickerson IM, Russo AF. Calcitonin gene-related peptide receptor activation by receptor ac-tivity-modifying protein-1 gene transfer to vascular smooth muscle cells[J]. Endocrinology, 2006, 147 (4):1932-1940. [20] Tian G, Zhang G, Tan YH. Calcitonin gene-related peptide stimulates BMP-2 expression and the dif-ferentiation of human osteoblast-like cells in vitro [J]. Acta Pharmacol Sin, 2013, 34(11):1467-1474. [21] Fang Z, Yang Q, Xiong W, et al. Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells[J]. PLoS One, 2013, 8(8):e72738. [22] Bischoff DS, Zhu JH, Makhijani NS, et al. Angio-genic CXC chemokine expression during differen-tiation of human mesenchymal stem cells towards the osteoblastic lineage[J]. J Cell Biochem, 2008, 103(3):812-824. [23] Suzuki A, Uemura T, Nakamura H. Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration[J]. Clin Calcium, 2010, 20(12):1820-1827. [24] Xu J, Kauther MD, Hartl J, et al. Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles[J]. J Orthop Surg Res, 2010, 5:83. [25] Kanczler JM, Oreffo RO. Osteogenesis and angio-genesis: the potential for engineering bone[J]. Eur Cell Mater, 2008, 15:100-114. [26] 陀泳华, 郭小磊, 张鑫鑫, 等. 降钙素基因相关肽对血管内皮细胞体外血管生成的作用及机制研究[J]. 中华骨科杂志, 2012, 32(8):781-787. Tuo YH, Guo XL, Zhang XX, et al. Effect of calci-tonin gene-related peptide on angiogenesis of human umbilical vein endothelial cells[J]. Chin J Orthopaed, 2012, 32(8):781-787. [27] Xiang L, Ma L, Wei N, et al. Effect of lentiviral vec-tor overexpression α-calcitonin gene-related peptide on titanium implant osseointegration in α-CGRP-deficient mice[J]. Bone, 2017, 94:135-140. |
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