国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (6): 832-838.doi: 10.7518/gjkq.2025099

• 综述 • 上一篇    

精神疾病与牙周疾病关联性的研究进展

连莹莹(),赵蕾()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2024-11-01 修回日期:2024-12-17 出版日期:2025-11-01 发布日期:2025-10-23
  • 通讯作者: 赵蕾
  • 作者简介:连莹莹，硕士，Email：lianyingy2024@163.com
  • 基金资助:
    四川省自然科学基金(2023NSFSC0553)

Research progress on the correlation between mental illness and periodontal diseases

Yingying Lian(),Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-11-01 Revised:2024-12-17 Online:2025-11-01 Published:2025-10-23
  • Contact: Lei Zhao
  • Supported by:
    Sichuan Natural Science Foundation Project(2023NSFSC0553)

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摘要：

近年来精神疾病的患病率在全球均呈逐年上升的趋势，精神健康问题越来越受到重视，而精神疾病在牙周疾病发生发展中扮演的角色亦逐渐受到学术界关注。精神状态异常可触发一系列生理反应，包括下丘脑-垂体-肾上腺轴激活、自主神经系统失衡以及免疫系统功能改变，这些反应通过影响骨形成、细菌毒力强弱、血管功能和免疫功能等，参与调控了牙周组织的健康状态。服用精神疾病类药物对牙周状态也有一定影响。本文系统阐释了精神疾病通过神经—内分泌—免疫网络调控牙周健康的多元机制，并将精神类药物纳入牙周病治疗的讨论框架，以期为建立精神疾病与口腔健康的跨学科防治策略提供一定参考。

关键词: 精神疾病, 牙周病, 下丘脑—垂体—肾上腺轴, 致病机制

Abstract:

In recent years, with the rising pressure faced by people, mental health problems have become progressively conspicuous. The prevalence of mental illness has been increasing annually on a global scale, and its potential role in perio-dontal disease development has gradually attracted academic attention. Abnormal mental states can initiate various physiological responses, including hypothalamic-pituitary-adrenal axis over-activation, autonomic nervous system imbalance, and immune system dysfunction. These responses are involved in the regulation of periodontal tissue health by affecting bone formation, bacterial virulence, vascular function, and immune responses. Furthermore, numerous studies have indicated that the use of psychotropic medications has a certain impact on periodontal health. However, current research on the relationship and mechanisms between the two remains limited. This study systematically elucidates the multifaceted mechanisms through which mental disorders regulate periodontal health via the neuro-endocrine-immune network. It also incorporates psychotropic medications into the therapeutic discourse on periodontal disease management. The findings aim to provide a theoretical foundation for developing interdisciplinary prevention and treatment strategies integrating mental and oral healthcare.

Key words: mental illness, periodontal disease, hypothalamic-pituitary-adrenal axis, pathogenesis

中图分类号: 

  • R781.4
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