国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (1): 25-33.doi: 10.7518/gjkq.2025018

• 口腔肿瘤专栏 • 上一篇    下一篇

碳点在口腔颌面部恶性肿瘤的诊断及治疗中的应用

符天宇1(),张雪2,王思琪1,郭程祎1,董晓宇1,程亚鹏1,李锐3()   

  1. 1.郑州大学口腔医学院 郑州 450052
    2.郑州大学第一附属医院口腔内科 郑州 450052
    3.郑州大学第一附属医院口腔颌面外科 郑州 450052
  • 收稿日期:2024-06-15 修回日期:2024-09-02 出版日期:2025-01-01 发布日期:2025-01-11
  • 通讯作者: 李锐
  • 作者简介:符天宇，学士，Email：3129531805@qq.com

Application of carbon dots to the diagnosis and treatment of oral and maxillofacial malignant tumors

Tianyu Fu1(),Xue Zhang2,Siqi Wang1,Chengyi Guo1,Xiaoyu Dong1,Yapeng Cheng1,Rui Li3()   

  1. 1.School of Stomatology, Zhengzhou University, Zhengzhou 450052, China
    2.Dept. of Oral Medicine, the First Affilia-ted Hospital of Zhengzhou University, Zhengzhou 450052, China
    3.Dept. of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2024-06-15 Revised:2024-09-02 Online:2025-01-01 Published:2025-01-11
  • Contact: Rui Li

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摘要：

近年来，随着纳米材料的发展和新型诊疗模式的进步，纳米医疗得到了研究者的广泛关注。碳点是一种具备荧光性能的零维纳米材料，可用于口腔癌诊疗，在提高检测灵敏度、减少药物不良反应及增强疗效上有明朗的前景，为口腔癌的诊疗提供了新的切入点。本文对基于碳点的口腔癌诊疗策略的研究进展进行综述，包括碳点在口腔癌的诊断、化学治疗、光动力治疗、光热治疗以及免疫治疗中的研究和应用，探讨碳点在口腔癌诊疗中的可行性，并对其在生物医学领域的进一步发展作出展望。

关键词: 碳点, 口腔癌, 诊断, 化学治疗, 光动力治疗, 光热治疗, 免疫治疗

Abstract:

Owing to advancements in nanomaterials and diagnostic and therapeutic modalities, nanomedicine has attracted considerable interest. Carbon dots are zero-dimensional nanomaterials with fluorescent properties and applicable to the diagnosis and treatment of oral cancer. They potentially enhance detection sensitivity, reduce adverse drug reactions, and improve therapeutic efficacy, thereby providing a new avenue for the management of oral cancer. This paper reviews progress in research on carbon-dot-based strategies for oral cancer diagnosis and treatment and their applications in chemotherapy, photodynamic therapy, photothermal therapy, and immunotherapy. It also explores the feasibility of using carbon dots in oral cancer management and potential development in the biomedical field.

Key words: carbon dots, oral cancer, diagnosis, chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy

中图分类号: 

  • R739.8

图1

PDT原理示意图"

图2

PTT原理示意图"

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