Abstract: Fluorine is one of the most important microelement in human body, which has crucial functions during the development of our teeth and the caries prevention. Overtaken of the fluorine during the odontogenesis will cause dental fluorosis. The particular pathological feature of the dental fluorosis implied the influences of the fluorid in odontogenesis directly and indirectly. Researches showed that, fluorid can influence the mineralization process through different ways, including the secreted enamel extracellular matrix, proteins, multiple proteases,
ameloblasts and transmembrane transport of the inorganic ions. Excess uptake of the fluorid can decrease the amount of the enamel and dentin matrix proteins, including collagen and noncollagen proteins which may influence
their normal functions during mineralization. So, it is widely accepted now that, fluorid have multiple effects on teeth formation and development. This review aims to outline the effects of fluoride on the biological processes involved
in the formation of tooth tissues.