Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 332-336.doi: 10.7518/gjkq.2022030

• Reviews • Previous Articles     Next Articles

Classification and treatment of dentin dysplasia type Ⅰ

Lei Bin1(),Chen Ke2()   

  1. 1.School of Stomatology, Jinan University, Guangzhou 510000, China
    2.Dept. of Pediatric Dentistry, Haizhu Square, Stomatological Hospital of Southern Medical University, Guangzhou 510000, China
  • Received:2021-07-21 Revised:2021-11-06 Online:2022-05-01 Published:2022-05-09
  • Contact: Ke Chen E-mail:435186977@qq.com;dentchenke@sohu.com
  • Supported by:
    High-level Talents Project of Stomatological Hospital, Southern Medical University(PY2018022)

RichHTML

164

PDF (PC)

865

Abstract:

Dentin dysplasia type Ⅰ (DD-Ⅰ) is a rare genetic disorder of dentine formation that affects all deciduous and permanent teeth. In this disease, the tooth crown’s appearance, color, and lustre are normal; tooth loosening is obvious; and spontaneous tooth alveolar abscess or cyst may be present. Imaging examinations show that the pulp cavity disappeared or the residual pulp has a “crescent shape” and the root is short and blunt or the root is absent. The pathogenesis of DD-Ⅰ has been studied by most scholars, and its clinical treatment is often challenging. In this paper, the clinical classification and manifestations, pathogenic genes, histological characteristics, and treatment of DD-Ⅰ in recent years are reviewed to provide guidance for the clinical diagnosis and treatment of this disease.

Key words: dentine dysplasia type Ⅰ, classification, pathogenesis, pathogenic gene, treatment

CLC Number: 

  • R 781.2

TrendMD: 

Fig 1

Sub-classification of DD Type Ⅰ"

Tab 1

Pathogenic genes of hereditary dentin disorders"

疾病类型基因位置致病基因
DGI-Ⅰ17q21.33COL1A1
7q21.3COL1A2
DGI-Ⅱ4q22.1DSPP
DGI-Ⅲ4q22.1DSPP
DD-Ⅰ6q27SMOC2
18q21.33VPS4B
3p26.1SSUH2
DD-Ⅱ4q22.1DSPP
1 Pitak-Arnnop P, Subbalekha K, Sirintawat N, et al. Clinical approach to rhizomicry based on a case of dentine dysplasia type 1[J]. J Stomatol Oral Maxillofac Surg, 2020, 121(2): 179-185.
2 Witkop CJ Jr, Jaspers MT. Teeth with short, thin, dilacerated roots in patients with short stature: a dominantly inherited trait[J]. Oral Surg Oral Med Oral Pathol, 1982, 54(5): 553-559.
3 O Carroll MK, Duncan WK, Perkins TM. Dentin dysplasia: review of the literature and a proposed subclassification based on radiographic findings[J]. Oral Surg Oral Med Oral Pathol, 1991, 72(1): 119-125.
4 Shields ED, Bixler D, el-Kafrawy AM. A proposed classification for heritable human dentine defects with a description of a new entity[J]. Arch Oral Biol, 1973, 18(4): 543-553.
5 Krug R, Volland J, Reich S, et al. Guided endodontic treatment of multiple teeth with dentin dysplasia: a case report[J]. Head Face Med, 2020, 16(1): 27.
6 Buchanan GD, Tredoux S, Nel C, et al. Endodontic treatment of dentin dysplasia type Ⅰ D[J]. Aust Endod J, 2021, 47(2): 343-349.
7 Kim JW, Simmer JP. Hereditary dentin defects[J]. J Dent Res, 2007, 86(5): 392-399.
8 Toomarian L, Mashhadiabbas F, Mirkarimi M, et al. Dentin dysplasia type Ⅰ: a case report and review of the literature[J]. J Med Case Rep, 2010, 4: 1.
9 de La Dure-Molla M, Philippe Fournier B, Berdal A. Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification[J]. Eur J Hum Genet, 2015, 23(4): 445-451.
10 Filippi A. Dentin dysplasia Type 1. Root dysplasia[J]. Schweiz Monatsschr Zahnmed, 2013, 123(2): 106-107.
11 Kim JW, Nam SH, Jang KT, et al. A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type Ⅱ[J]. Hum Genet, 2004, 115(3): 248-254.
12 Zhang XQ, Chen LY, Liu JY, et al. A novel DSPP mutation is associated with type Ⅱ dentinogenesis imperfecta in a Chinese family[J]. BMC Med Ge-net, 2007, 8: 52.
13 Lee SK, Hu JC, Lee KE, et al. A dentin sialophosphoprotein mutation that partially disrupts a splice acceptor site causes type Ⅱ dentin dysplasia[J]. J Endod, 2008, 34(12): 1470-1473.
14 Hart PS, Hart TC. Disorders of human dentin[J]. Cells Tissues Organs, 2007, 186(1): 70-77.
15 刘芬. 遗传性牙本质发育异常的临床及相关基础研究[D]. 西安: 第四军医大学, 2013.
Liu F. Clinical and related basic research for hereditary dentinogenesis imperfecta[D]. Xi’an: The Fourth Military Medical University, 2013.
16 Yang Q, Chen D, Xiong F, et al. A splicing mutation in VPS4B causes dentin dysplasia Ⅰ[J]. J Med Ge-net, 2016, 53(9): 624-633.
17 邓敏, 胡爱琴, 熊符. 遗传性牙本质发育异常的分子遗传学研究进展[J]. 国际遗传学杂志, 2017, 40(6): 361-367.
Deng M. Hu AQ, Xiong F. Progress in molecular genetics of inherited dentine dysplasia[J]. Int J Genet, 2017, 40(6): 361-367.
18 Chen D, Li X, Lu F, et al. Dentin dysplasia type Ⅰ-a dental disease with genetic heterogeneity[J]. Oral Dis, 2019, 25(2): 439-446.
19 Sloan AJ, Smith AJ. Stem cells and the dental pulp: potential roles in dentine regeneration and repair[J]. Oral Dis, 2007, 13(2): 151-157.
20 Pan YH, Lu T, Peng L, et al. Vacuolar protein sor-ting 4B regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells through the Wnt‑β‑catenin signalling pathway[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1): 2575-2584.
21 Hu AQ, Lu T, Chen DN, et al. Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia Ⅰ[J]. BMC Genet, 2019, 20(1): 7.
22 Xiong F, Ji ZS, Liu YH, et al. Mutation in SSUH2 causes autosomal-dominant dentin dysplasia type Ⅰ[J]. Hum Mutat, 2017, 38(1): 95-104.
23 Vannahme C, Gösling S, Paulsson M, et al. Characterization of SMOC-2, a modular extracellular cal-cium-binding protein[J]. Biochem J, 2003, 373(Pt 3): 805-814.
24 Bloch-Zupan A, Jamet X, Etard C, et al. Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects[J]. Am J Hum Genet, 2011, 89(6): 773-781.
25 Alfawaz S, Fong F, Plagnol V, et al. Recessive oligodontia linked to a homozygous loss-of-function mutation in the SMOC2 gene[J]. Arch Oral Biol, 2013, 58(5): 462-466.
26 Pintor A, Alexandria A, Marques A, et al. Histological and ultrastructure analysis of dentin dysplasia type Ⅰ in primary teeth: a case report[J]. Ultrastruct Pathol, 2015, 39(4): 281-285.
27 Melnick M, Levin LS, Brady J. Dentin dysplasia type Ⅰ: a scanning electron microscopic analysis of the primary dentition[J]. Oral Surg Oral Med Oral Pathol, 1980, 50(4): 335-340.
28 Ye X, Li KY, Liu L, et al. Dentin dysplasia type Ⅰ-novel findings in deciduous and permanent teeth[J]. BMC Oral Health, 2015, 15: 163.
29 Da Rós Gonçalves L, Oliveira CA, Holanda R, et al. Periodontal status of patients with dentin dysplasia type Ⅰ: report of three cases within a family[J]. J Periodontol, 2008, 79(7): 1304-1311.
30 Depprich RA, Ommerborn MA, Handschel JG, et al. Dentin dysplasia type Ⅰ: a challenge for treatment with dental implants[J]. Head Face Med, 2007, 3: 31.
31 Muñoz-Guerra MF, Naval-Gías L, Escorial V, et al. Dentin dysplasia type Ⅰ treated with onlay bone grafting, sinus augmentation, and osseointegrated implants[J]. Implant Dent, 2006, 15(3): 248-253.
32 Khandelwal S, Gupta D, Likhyani L. A case of dentin dysplasia with full mouth rehabilitation: a 3-year longitudinal study[J]. Int J Clin Pediatr Dent, 2014, 7(2): 119-124.
33 Bespalez-Filho R, Couto Sde A, Souza PH, et al. Orthodontic treatment of a patient with dentin dysplasia type Ⅰ[J]. Am J Orthod Dentofacial Orthop, 2013, 143(3): 421-425.
[1] Wang Nannan,He Hong,Hua Fang. Research progress on the risk factors of orthodontically induced enamel demineralization [J]. Int J Stomatol, 2024, 51(1): 91-98.
[2] Han Chong,He Dongning,Yu Feiyan,Wu Dongchao. Research progress on the mechanism and treatment of pain after oral implants [J]. Int J Stomatol, 2024, 51(1): 99-106.
[3] Xia Weiyao,Jia Zhonglin. Research progress on the relationship between vitamin and oral clefts [J]. Int J Stomatol, 2023, 50(6): 632-638.
[4] Sun Xu,Deng Zhennan,Wen Cai,Zhao Ying. Implant surface micromorphological changes after Er: YAG laser irradiation observed under scanning electron microscope [J]. Int J Stomatol, 2023, 50(6): 669-673.
[5] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[6] Chai An,Lei Rongchang,Jiang Zhisheng,Qu Binbin,Guo Jincai,Li He,Shao Qi. Review of classification methods for evaluating the difficulty of mandibular third molar extraction [J]. Int J Stomatol, 2023, 50(6): 718-722.
[7] Liu Yang,Yin Deqiang. Introducing a novel digital articulation workflow with high precision [J]. Int J Stomatol, 2023, 50(5): 499-505.
[8] Ji Xiao,Zhang Lan,Huang Dingming.. Diagnosis and treatment of odontogenic and non-odontogenic maxillary sinusitis [J]. Int J Stomatol, 2023, 50(5): 566-572.
[9] Zhao Yuanxi,Su Qin.. Application and development of supplementary techniques in removing the remaining filling materials of root canal retreatment [J]. Int J Stomatol, 2023, 50(5): 581-586.
[10] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[11] Liu Ting,Wu Xiuping.. Research progress on oral-craniomaxillofacial features and treatment of Down syndrome [J]. Int J Stomatol, 2023, 50(5): 618-622.
[12] Zhang Chaoying,Li Yining,Gong Jiaxing,Wang Huiming. Interpretation of the 2022 classification of head and neck tumors by the World Health Organization: odontogenic and maxillofacial bone tumors [J]. Int J Stomatol, 2023, 50(3): 263-271.
[13] Xia Weiyao,Luo Yankun,Jia Zhonglin. Review of the precise diagnosis and genetic etiology of Pierre Robin sequence [J]. Int J Stomatol, 2023, 50(3): 287-292.
[14] Qin Yichun,Tan Xuelian,Huang Dingming.. Clinical research progress on glandular odontogenic cyst [J]. Int J Stomatol, 2023, 50(1): 100-107.
[15] Li Ting,Yang Xuecai,Wang Junwei.. Children with Williams-Beuren syndrome associated with cranial and maxillofacial deformity [J]. Int J Stomatol, 2023, 50(1): 108-113.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .