Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (1): 119-124.doi: 10.7518/gjkq.2021009

• Reviews • Previous Articles    

Etiology and treatment of pruritus of the oral mucosa

Tao Huiqian,Dan Hongxia()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Key Laboratory of Oral Mucosal Diseases & Innovation Unit of Oral Mucosal Carcinogenesis and Prevention, Chinese Academy of Medical Sciences & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-04-26 Revised:2020-09-10 Online:2021-01-01 Published:2021-01-20
  • Contact: Hongxia Dan E-mail:hxdan@foxmail.com
  • Supported by:
    This study was supported by National Nature Science Foundation of China(81572663)

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Abstract:

Pruritus of oral mucosa is a kind of unpleasant feeling at one or more sites of the mucous membrane in the mouth that can cause scratching desire. It triggers tongue licking, biting, and hand scratching, leading to an itch-scratch cycle. It affects the daily life of patients to various extent. The causes of pruritus of oral mucosa are complex and diverse, involving both intra-oral and extra-oral factors. With the increasing demand of oral health care, many patients are searching for advice to solve this problem. The purpose of this review is to summarize the potential etiology and treatment options of pruritus of the oral mucosa in order to help the clinicians with the management of this symptom.

Key words: oral mucosa, pruritus, etiology, treatment

CLC Number: 

  • R781.5

TrendMD: 

Fig 1

The treatment of pruritus of the oral mucosa"

[1] Bedolla-Barajas M, Kestler-Gramajo A, Alcalá-Padilla G , et al. Prevalence of oral allergy syndrome in children with allergic diseases[J]. Allergol Immunopathol (Madr), 2017,45(2):127-133.
[2] Osawa Y, Ito Y, Takahashi N , et al. Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions[J]. Allergol Int, 2020,69(2):246-252.
doi: 10.1016/j.alit.2019.09.008 pmid: 31708436
[3] Dong XT, Dong XZ . Peripheral and central mechanisms of itch[J]. Neuron, 2018,98(3):482-494.
pmid: 29723501
[4] Voisin T, Chiu IM . Mast cells get on your nerves in itch[J]. Immunity, 2019,50(5):1117-1119.
[5] Meixiong J, Anderson M, Limjunyawong N , et al. Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch[J]. Immunity, 2019, 50(5): 1163- 1171. e5.
[6] Amber KT, Valdebran M, Kridin K , et al. The role of eosinophils in bullous pemphigoid: a developing model of eosinophil pathogenicity in mucocuta-neous disease[J]. Front Med (Lausanne), 2018,5:201.
[7] Leiferman KM . Eosinophils and itch: partners in crime or strange bedfellows[J]. J Allergy Clin Immunol, 2015,135(2):488-490.
[8] 王炫, 殷操 . 自伤性溃疡与儿童心理行为相关因素的临床分析[J]. 现代医院, 2011,11(1):9-10.
Wang X, Yin C . Clinical analysis of self-inflicted ulcers and children's psychological and behavioral factors[J]. Mod Hosp, 2011,11(1):9-10.
[9] 陈谦明, 曾昕 . 案析口腔黏膜病学[M]. 北京: 人民卫生出版社, 2014.
Chen QM, Zeng X. Case based oral mucosal di-seases[M]. Beijing: People's Medical Publishing House, 2014.
[10] Bernstein DI, Teper A, Gopalan G , et al. Effects of intranasal mometasone furoate on itchy ear and pa-late in patients with seasonal allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2012,108(5):359-362.
[11] Hussein H, Mensah RK, Brown RS . Diagnosis and management of oral allergy syndrome, the itchy tongue allergic reaction[J]. Compend Contin Educ Dent, 2019,40(8):502-506.
pmid: 31478696
[12] 杨敏 . 儿童口腔过敏综合征[J]. 中国实用儿科杂志, 2017,32(10):736-739.
Yang M . Oral allergy syndrome in children[J]. Chin J Pract Pediatr, 2017,32(10):736-739.
[13] Fischer DA . Seasonal palatal pruritus is a risk factor for oral allergy syndrome[J]. J Allergy Clin Immunol, 2007,119(1):S194.
[14] Muluk NB, Cingi C . Oral allergy syndrome[J]. Am J Rhinol Allergy, 2018,32(1):27-30.
pmid: 29336286
[15] 张子衿, 祝钧, 孟宏 , 等. 老年性瘙痒症发病机制研究进展[J]. 中国老年学杂志, 2018,38(18):4598-4600.
Zhang ZJ, Zhu J, Meng H , et al. Advances in the pathogenesis of pruritus senile[J]. Chin J Gerontol, 2018,38(18):4598-4600.
[16] Valdes-Rodriguez R, Stull C, Yosipovitch G . Chro-nic pruritus in the elderly: pathophysiology, diagnosis and management[J]. Drugs Aging, 2015,32(3):201-215.
[17] Valdes-Rodriguez R, Mollanazar NK, González-Muro J , et al. Itch prevalence and characteristics in a Hispanic geriatric population: a comprehensive stu-dy using a standardized itch questionnaire[J]. Acta Derm Venereol, 2015,95(4):417-421.
[18] Shevchenko A, Valdes-Rodriguez R, Yosipovitch G . Causes, pathophysiology, and treatment of pruritus in the mature patient[J]. Clin Dermatol, 2018,36(2):140-151.
[19] Hashimoto T, Yosipovitch G . Itching as a systemic disease[J]. J Allergy Clin Immunol, 2019,144(2):375-380.
[20] 杨亚南 . 糖尿病性皮肤瘙痒患者的护理研究新进展[J]. 皮肤病与性病, 2019,41(4):503-504.
Yang YN . Progress in nursing research of skin pru-ritus of diabetic patients[J]. Dermatol Venereol, 2019,41(4):503-504.
[21] Bustan RS, Wasim D, Yderstræde KB , et al. Speci-fic skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state‒a systematic review[J]. Dan Med J, 2017,64(1):A5316.
pmid: 28007053
[22] Moore PA, Guggenheimer J, Orchard T . Burning mouth syndrome and peripheral neuropathy in patients with type 1 diabetes mellitus[J]. J Diabetes Complicat, 2007,21(6):397-402.
[23] Lima AL, Illing T, Schliemann S , et al. Cutaneous manifestations of diabetes mellitus: a review[J]. Am J Clin Dermatol, 2017,18(4):541-553.
[24] Carpenter RM, Wongward J. Graves' disease presen-ting as severe postpartum pruritus[J]. BMJ Case Rep, 2018, 2018: bcr-2018-225347.
pmid: 33431542
[25] Welz-Kubiak K, Reszke R, Szepietowski JC . Pruritus as a sign of systemic disease[J]. Clin Dermatol, 2019,37(6):644-656.
doi: 10.1016/j.clindermatol.2019.07.031 pmid: 31864443
[26] Fahmey SS, Taha G, El-Refaey A , et al. Skin disorders in Egyptian children with β-thalassemia major[J]. J Trop Pediatr, 2018,64(2):104-109.
pmid: 28510704
[27] Brigant F, Hautefeuille V, Dadban A , et al. Genera-lized pruritus in dysmetabolic hyperferritinemia treated by phlebotomy[J]. Dermatol Online J, 2015,21(9): 13030/qt4qg8m234.
pmid: 26437279
[28] Tolkachjov SN, Bruce AJ . Oral manifestations of nutritional disorders[J]. Clin Dermatol, 2017,35(5):441-452.
[29] Sanders KM, Akiyama T . The vicious cycle of itch and anxiety[J]. Neurosci Biobehav Rev, 2018,87:17-26.
[30] Lee HG, Stull C, Yosipovitch G . Psychiatric disorders and pruritus[J]. Clin Dermatol, 2017,35(3):273-280.
pmid: 28511824
[31] Zhao P, Hiramoto T, Asano Y , et al. Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice[J]. Pharmacol Biochem Behav, 2013,105:173-176.
doi: 10.1016/j.pbb.2013.02.014 pmid: 23474370
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .