Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 115-120.doi: 10.7518/gjkq.2020029

• Orginal Article • Previous Articles     Next Articles

Progress for understanding the effect of berberine in oral diseases

Cui Yujia,Sun Jianxun(),Zhou Xuedong   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-07 Revised:2019-09-24 Online:2020-01-01 Published:2020-01-01
  • Contact: Jianxun Sun
  • Supported by:
    This study was supported by Sichuan Science and Technology Pillar Program(2016RZ0035)


Berberine is a benzylisoquinoline alkaloid, occurring as one of the main active ingredients in many traditional herbs including coptis, barberry, phellodendron. Several studies have depicted its anticonvulsant, antihypertensive, antidepressant, anti-inflammatory, hypolipidemic, and antidiabetic biological effect. Depending on a rich and varied biological function, the potential of berberine for curing oral diseases has been discovered recently. Researchers focus on the relation of berberine to oral diseases, such as periodontitis, caries, periapical periodontitis, diseases of oral mucosa, oral/maxillofacial. The review pays attention to the biological function of berberine as well as its roles in oral diseases.

Key words: berberine, caries, periapical periodontitis, periodontitis, diseases of oral mucosa, tumor

CLC Number: 

  • R78

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