Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 302-307.doi: 10.7518/gjkq.2019006

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Research progress on regulatory mechanism of the circadian clock genes on osteogenesis and bone resorption

Wei Hu,Yifan Wang,Yifang Yuan,Ying Li,Bin Guo()   

  1. Dept. of Stomatology, The People’s Liberation Army General Hospital, Beijing 100853, China
  • Received:2018-08-21 Revised:2019-02-25 Online:2019-05-01 Published:2019-06-05
  • Contact: Bin Guo E-mail:guobin0408@126.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81470754)

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Abstract:

The internal circadian timing system of human is a major regulatory network mainly interacting circadian genes for regulating 24 h rhythms of many metabolic and physiological processes. The dynamic balance of osteogenesis and bone resorption is the foundation of normal bone function. The circadian genes, which are closely related to osteogenesis and bone resorption, play an essential regulatory role in bone remolding and may be targets of bone regenerative medicine. This review focuses on the circadian timing system structure and the recent progress of research on regulatory mechanism of osteogenesis and bone resorption. We aim to possibly determine a novel approach for bone reconstruction and regenerative therapy.

Key words: biorhythms, circadian gene, osteogenic differentiation, osteoclast

CLC Number: 

  • Q753

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