Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (1): 46-49.doi: 10.7518/gjkq.2018.01.009

• Original Articles • Previous Articles     Next Articles

Functions of microRNA on the osteogenic differentiation of human periodontal ligament-derived cells

Hao Yilin, Fang Fuchun, Wu Buling   

  1. Dept. of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2017-05-11 Revised:2017-10-20 Online:2018-01-01 Published:2018-01-01
  • Supported by:
    This work was supported by National Natural Science Foundation of China (81600882) and Medical Science and Technology Research Fundation of Guangdong Province (A2016190).

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Abstract: Human periodontal ligament-derived cells are a group of heterogeneous cells, which can differentiate into osteoblasts, participate in remodeling and repair of alveolar bone remodeling, and periodontal regeneration. MicroRNAs (miRNAs) are thought to play a key role in the regulation of cell differentiation and be key factors in maintaining cell differentiation and regulating differentiation. MicroRNA plays a promotion or inhibition role on osteogenic differentiation by targeting mRNA. In this review, we summarized the different miRNAs in the osteogenic differentiation of periodontal-derived cells, focusing on the function and regulation of target genes and pathways under the mineralized or mechanical force induced conditions.

Key words: microRNA, periodontal ligament stem cell, periodontal ligament cell, osteogenic differentiation

CLC Number: 

  • Q254

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