Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (3): 318-322.doi: 10.7518/gjkq.2015.03.018

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Hypoxia-inducible factor-1α and oral lichen planus

Wang Xiaxia, Sun Hongying   

  1. Dept. of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2014-07-14 Revised:2015-01-20 Online:2015-05-01 Published:2015-05-01

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Abstract:

Hypoxia-inducible factor(HIF)-1 is an important transcription factor in cellular adaptation to hypoxic conditions is involved in regulating immune cell differentiation, promoting the adhesion and influence the formation of cell metabolism, inducing new blood vessels, and regulating cell proliferation and apoptosis, among others. In recent years, studies have shown that HIF-1α may play an important role in the pathogenesis of oral lichen planus. This article reviewed the research progress onHIF-1inthe following aspects: the structure, function, and regulation of HIF-1, immune inflammatory response in the expression of HIF-1α, and the role of HIF-1α in the occurrence and development of oral lichen planus.

Key words: oral lichen planus, immunity, inflammation, hypoxia-inducible factor-1α

CLC Number: 

  • R 781.5

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