国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (3): 290-295.doi: 10.7518/gjkq.2022034

• 微生物专栏 • 上一篇    下一篇

粪肠球菌与口腔微生物相互作用的研究进展

刘千溪1(),吴佳益2,任彪3,黄睿洁1()   

  1. 1.口腔疾病研究国家重点实验室;国家口腔疾病临床医学研究中心;四川大学华西口腔医院儿童口腔科 成都 610041
    2.口腔疾病研究国家重点实验室;国家口腔疾病临床医学研究中心;四川大学华西口腔医院牙体牙髓病科 成都 610041
    3.口腔疾病研究国家重点实验室;国家口腔疾病临床医学研究中心;四川大学华西口腔医学院 成都 610041
  • 收稿日期:2021-06-01 修回日期:2021-11-22 出版日期:2022-05-01 发布日期:2022-05-09
  • 通讯作者: 黄睿洁
  • 作者简介:刘千溪,学士,Email:980098145@qq.com
  • 基金资助:
    国家自然科学基金(NSFC31800114);四川大学大学生创新创业训练计划(202010611316)

Research progress on the interactions between Enterococcus faecalis and other oral microorganisms

Liu Qianxi1(),Wu Jiayi2,Ren Biao3,Huang Ruijie1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    3.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-06-01 Revised:2021-11-22 Online:2022-05-01 Published:2022-05-09
  • Contact: Ruijie Huang
  • Supported by:
    National Natural Science Foundation of China(NSFC31800114);Sichuan University Innovation and Entrepreneurship Training Program under Grants(202010611316)

摘要:

口腔微生物不同种群之间的相互作用显著影响口腔疾病的发生发展。粪肠球菌是口腔中常见的条件性致病菌,当免疫防御机制发生变化时,易引发感染,如难治性根尖周炎等。粪肠球菌可单独形成生物膜,并可分泌明胶酶和溶细胞素等多种物质导致感染。粪肠球菌与白色念珠菌、金黄色葡萄球菌、牙龈卟啉单胞菌、放线菌属、链球菌属等常从根尖周炎、牙周炎病灶中共同检出,存在显著的相互作用关系。本文通过粪肠球菌与其他口腔的常见口腔致病菌的相互作用促进口腔相关疾病发生发展的研究进展进行综述,为牙周炎、根尖周炎等感染性疾病的防治策略研究提供参考。

关键词: 粪肠球菌, 白色念珠菌, 微生物相互作用, 口腔疾病

Abstract:

Interactions among different oral microbes play an important role in the occurrence and development of oral diseases. Enterococcus faecalis contributes to various inflammatory diseases by forming biofilm and secreting harmful substances, including gelatinase and cytolysin. It becomes an opportunistic pathogen in case of low immunity. Enterococcus faecalis can be detected together and interact with other pathogenic microbes, such as Candida albicans, Staphylococcus aureus, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Streptococcus mutans from a series of oral lesions, including pulpitis, periapical periodontitis and periodontitis. This review summarised the research progress on studies about the interactions between Enterococcus faecalis and other oral pathogens and focuses on their combination effects in oral diseases to provide a new version for clinical prevention and treatment.

Key words: Enterococcus faecalis, Candida albicans, microbial interaction, oral disease

中图分类号: 

  • R 37

表 1

粪肠球菌与口腔常见致病菌协同致病机制及表现"

检出病灶菌种作用机制作用表现对疾病的影响
根尖周炎粪肠球菌与白色念珠菌基因ROB1、NDT80、BRG1ALS3的表达上调

生物膜增大增厚

侵袭力增强

降低机体免疫应答

感染迁延不愈
粪肠球菌与变异链球菌

生物膜增大增厚

抗药性增强

促进感染进展

抗菌药疗效降低

粪肠球菌与戈登链球菌pAM373质粒转移耐药性增强抗生素疗效降低
粪肠球菌与金黄色葡萄球菌vanA质粒转移耐药性增强抗生素疗效降低
牙周炎粪肠球菌与牙龈卟啉单胞菌、伴放线放线杆菌上调人体IRAK-M的表达降低机体免疫应答

感染迁延不愈

难治性牙周炎

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