国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (4): 380-384.doi: 10.7518/gjkq.2021081

• 牙周专栏 • 上一篇    下一篇

甲状腺功能减退症与牙周炎相关性的研究进展

朱轩智(),赵蕾()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2021-01-05 修回日期:2021-03-27 出版日期:2021-07-01 发布日期:2021-06-30
  • 通讯作者: 赵蕾
  • 作者简介:朱轩智,硕士,Email: 826868536@qq.com
  • 基金资助:
    国家自然科学基金面上项目(81970944)

Research progress on the relationship between hypothyroidism and periodontitis

Zhu Xuanzhi(),Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-05 Revised:2021-03-27 Online:2021-07-01 Published:2021-06-30
  • Contact: Lei Zhao
  • Supported by:
    National Natural Science Foundation of China(81970944)

摘要:

甲状腺通过分泌甲状腺激素参与调节多种生理活动,其功能异常将导致骨代谢紊乱,甚至引发骨质疏松。牙周炎是由菌斑生物膜引发的慢性炎症类疾病,以牙槽骨吸收破坏为首要特征之一。临床数据与动物实验均表明:甲状腺功能减退症与牙周疾病存在相关性。甲状腺功能减退可能通过调节下游激素受体的激活,影响骨代谢与免疫因子的表达,进而抑制牙槽骨成骨,促进骨吸收。此外,甲状腺功能减退所引发的低转换型骨质疏松症可能是加重牙周炎进展的全身系统性条件。本文就两类疾病的相关性与可能的作用机制进行综述。

关键词: 甲状腺功能减退症, 骨代谢, 牙周炎, 种植体

Abstract:

The thyroid gland regulates various physiological activities by secreting thyroid hormones, and its abnormal function can lead to bone metabolism disorders and osteoporosis. Periodontitis is a chronic inflammatory disease caused by plaque biofilm, and alveolar bone resorption is one of its primary features. Clinical trials and animal experiments indicated that hypothyroidism is positively related to periodontal disease. Hypothyroidism may affect bone metabolism and the expression of immune factors by regulating the activation of downstream hormone receptors, thereby inhibiting alveolar bone osteogenesis and promoting bone resorption. In addition, low-turnover osteoporosis caused by hypothyroidism may be a systemic condition that aggravates the progression of periodontitis. This article reviews the relevance and possible mechanisms of the above two diseases.

Key words: hypothyroidism, bone metabolism, periodontitis, dental implant

中图分类号: 

  • R781.4
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